Results 21 to 30 of about 26,509 (243)

Direct synthesis of functionalized 3-pyrrolidines and 4-piperidines using the borrowing hydrogen methodology

, 2023
The Ir(III)-catalyzed synthesis of 3-pyrrolidinols and 4-piperidinols combining 1,2,4-butanetriol or 1,3,5-pentanetriol with primary amines was carried out.
Florence, Popowycz, Maiwenn, Jacolot, Jordan, François, Malvina, Larduinat   +3 more
core   +1 more source

Enantioselective Synthesis of Pyrrolidines by Imidodiphosphorimidate (IDPi)-catalysed anti-hydroamination of alkenes

, 2023
Chiral pyrrolidines are common structural motives in natural products as well as active pharmaceutical ingredients explaining the need for methods for their enantioselective synthesis.
Ruben, Van Lommel, Constantin G., Daniliuc, Ulrich, Hennecke, Raffi, Khudaverdyan, Alexander N., Volkov, Frank, De Proft, Sudip, Guria   +6 more
core   +1 more source

Diastereoselective Preparation of Azetidines and Pyrrolidines

, 2016
Iodine-mediated cyclization of homoallyl amines at room temperature delivered cis-2,4-azetidine through a 4-exo trig cyclization. Isomerization of iodo-azetidines to cis-pyrrolidines could be achieved by heating, with complete stereocontrol. The relative
John S. Fossey (1392100), Antonio Feula (1536742), Louise Male (1335048)   +2 more
core   +3 more sources

Highly stereocontrolled total synthesis of racemic codonopsinol B through isoxazolidine-4,5-diol vinylation

Beilstein Journal of Organic Chemistry, 2021
A new highly diastereoselective synthesis of the polyhydroxylated pyrrolidine alkaloid (±)-codonopsinol B and its N-nor-methyl analogue, starting from achiral materials, is presented.
Lukáš Ďurina, Anna Ďurinová, František Trejtnar, Ľuboš Janotka, Lucia Messingerová, Jana Doháňošová, Ján Moncol, Róbert Fischer   +7 more
doaj   +1 more source

Brønsted base-catalyzed assembly of sulfochromeno [4,3-b] pyrrolidines via tandem [3+2] cycloaddition-SuFEx click reaction of ethenesulfonyl fluorides and azomethine ylides

, 2022
The synthesis of sulfochromeno [4,3-b] pyrrolidines is described. Under the catalysis of 20 mol% Brønsted base and using 4Å molecular sieves as HF scavenger, imines derived from salicylaldehydes and diethyl aminomalonate react with ethenesulfonyl ...
Qichao, Zhang, Jichang, Liu, Fang, Zhang, Lin, He, Bin, Dai   +4 more
core   +1 more source

Synthesis and Biological Study of Some New Pyrrolidines [PDF]

مجلة التربية والعلم, 2007
A series of Schiff bases N-Arylidene benzylamie (1-6) have been prepared, and through 1,3-anionic cycloaddition under strong basic conditions were added to benzoquinone to afford the fused new pyrrolidines (7-12).
A.J. Al-Hamdany, A. Mustafa, M. Abdulrahman   +2 more
doaj   +1 more source

1,3-Dipolar Cycloadditions of N-Benzyl Furfuryl Nitrones with Electron-rich Alkenes

Molecules, 2000
The 1,3-dipolar cycloaddition reaction of N-benzyl-C-(2-furyl)nitrones with electron-rich alkenes gives preferentially trans-substituted 3,5-disubstituted isoxazolidines (endo approach).
Tomas Tejero, Francisco L. Merchan, Sonia Anoro, Pedro Merino   +3 more
doaj   +1 more source

Asymmetric Deprotonation by BuLi/(−)-Sparteine:  Convenient and Highly Enantioselective Syntheses of (S)-2-Aryl-Boc-Pyrrolidines

, 2016
Highly enantioselective syntheses of (S)-2-aryl-Boc-pyrrolidines (Boc = tert-butoxycarbonyl) can be achieved by treatment of the corresponding (arylmethyl)(3-chloropropyl)-Boc-amines with s-BuLi/(−)-sparteine. The reactions are solvent dependent with the
Steven Lee (72507), Peter Beak (2402176), Shengde Wu (748596)   +2 more
core   +2 more sources

Synthesis of 1-phenyl-3-pyrroline in water

Orbital: The Electronic Journal of Chemistry, 2012
Pyrrolines are bioactive compounds and can be used as starting materials or as intermediates in the synthesis of natural products [1,2]. N-phenyl-pyrrolines have been prepared by reaction of N-propargylanilines catalyzed by Cu(I) [3] or the ring-closing ...
Thiago Muniz de Souza, Ivani Malvestiti, Lothar W. Bieber   +2 more
doaj   +1 more source

Stable D-xylose ditriflate in divergent syntheses of dihydroxy prolines, pyrrolidines, tetrahydrofuran-2-carboxylic acids, and cyclic sugar -amino acids

, 2022
Double nucleophilic displacement of a sugar D-xylose ditriflate derived from diacetone-D-glucose by amines, water and alkyl cyanoacetates gave a series of bicyclic divergent intermediates for the synthesis of a wide range of highly functionalized targets,
Soufian, El Ayadi, Alejandro, Jiménez, Alberto G., Fernandez, Rosalino, Balo, Adam, Chopdat, Ramon J., Estevez, George W. J., Fleet, Estevez Cabanas, Juan Carlos, Atsushi , Kato   +8 more
core   +1 more source