Results 51 to 60 of about 26,509 (243)

Transient and intermediate carbocations in ruthenium tetroxide oxidation of saturated rings

Beilstein Journal of Organic Chemistry, 2019
The ruthenium tetroxide-mediated oxidation of cyclopentane, tetrahydrofuran, tetrahydrothiophene and N-substituted pyrrolidines has been studied computationally by DFT and topological (analysis of the electron localization function, ELF) methods.
Manuel Pedrón, Laura Legnani, Maria-Assunta Chiacchio, Pierluigi Caramella, Tomás Tejero, Pedro Merino   +5 more
doaj   +1 more source

Probing the Influence of Linker Length and Flexibility in the Design and Synthesis of New Trehalase Inhibitors

Molecules, 2018
This work aims to synthesize new trehalase inhibitors selective towards the insect trehalase versus the porcine trehalase, in view of their application as potentially non-toxic insecticides and fungicides.
Giampiero D’Adamio, Matilde Forcella, Paola Fusi, Paolo Parenti, Camilla Matassini, Xhenti Ferhati, Costanza Vanni, Francesca Cardona   +7 more
doaj   +1 more source

Effect of Some Synthesized Pyrrolidines in Growth of L. infantum Promastigotes

Tikrit Journal of Pure Science, 2023
In this research, three pyrrolidine compounds (P1-P3) were synthesized and then tested for efficacy against L. infantum promastigotes in vitro. The study included preparation of some chalcones and schiff bases then the condensation of both to get the
Haitham L. Al-Hayali, Abdulwahhab J. Al-Hamadany, Muntaha M. Al-Kattan   +2 more
doaj   +1 more source

Breaking the Durability–Power Trade‐Off: Boron‐Directed Faceted O3 Cathodes for High‐Rate Sodium‐Ion Batteries

Advanced Energy Materials, EarlyView.
Boron‐oxide‐assisted particle engineering stabilizes O3‐type layered cathodes for sodium‐ion batteries by mitigating phase transitions and lattice strain. Acting as flux and structural modifier, boron forms submicron hexagonal platelets with (003) facets and expanded Na‐layer spacing, enabling rapid Na⁺ diffusion and mechanical resilience.
Tengfei Song, Alexis Manche, Dongrui Xie, Bowen Liu, Chenglong Wu, Bo Dong, Reda Malakauskaite, Manoj Ovhal, David O. Scanlon, Emma Kendrick   +9 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Synthesis of new pyrrolidine-based organocatalysts and study of their use in the asymmetric Michael addition of aldehydes to nitroolefins

Beilstein Journal of Organic Chemistry, 2017
New pyrrolidine-based organocatalysts with a bulky substituent at C2 were synthesized from chiral imines derived from (R)-glyceraldehyde acetonide by diastereoselective allylation followed by a sequential hydrozirconation/iodination reaction.
Alejandro Castán, Ramón Badorrey, José A. Gálvez, María D. Díaz-de-Villegas   +3 more
doaj   +1 more source

Current applications of kinetic resolution in the asymmetric synthesis of substituted pyrrolidines [PDF]

, 2021
Chiral substituted pyrrolidines are key elements in various biologically active molecules and are therefore valuable synthetic targets. One traditional method towards enantiomerically pure compounds is the application of kinetic resolution.
Jones, S., Berry, S.S.
core   +1 more source

Domino Elimination/Nucleophilic Addition in the Synthesis of Chiral Pyrrolidines

, 2016
Polyhydroxylated pyrrolidines have been synthesized in a one-pot procedure by the addition of an organometallic reagent to isoxazolidines obtained by a 1,3-dipolar cycloaddition between nitrones and vinylsulfones.
MariFe Flores (1933924), Pilar García-García (1933918), Isidro S. Marcos (1608433), Francisca Sanz-González (1933921), Narciso M. Garrido (1933915), David Díez (1581166)   +5 more
core   +2 more sources

Synthesis and biological evaluation of nojirimycin- and pyrrolidine-based trehalase inhibitors

Beilstein Journal of Organic Chemistry, 2012
A small set of nojirimycin- and pyrrolidine-based iminosugar derivatives has been synthesized and evaluated as potential inhibitors of porcine and insect trehalases.
Davide Bini, Francesca Cardona, Matilde Forcella, Camilla Parmeggiani, Paolo Parenti, Francesco Nicotra, Laura Cipolla   +6 more
doaj   +1 more source

Alcohol-Directed Carboamination of Conjugated Enynes. [PDF]

Angew Chem Int Ed Engl
The first general three‐component intermolecular Pd‐catalyzed carboamination of conjugated enynes enables the coupling of anilines and aryl triflates to produce functionalized allenic amines, utilizing a native alcohol directing group to control regioselectivity.
Solé-Àvila H, Brownsey DK, Senelle H, Waser J.   +3 more
europepmc   +3 more sources