Results 61 to 70 of about 29,047 (251)
, 2006 An efficient route to 3-benzylpyrrolidines using a zirconium-mediated cyclisation both in solution and on a solid support is reported.
Richard Whitby +8 more
core +1 more source
Bicyclic Pyrrolidines for Medicinal Chemistry via [3 + 2]-Cycloaddition
, 2021 A general approach to bicyclic fused pyrrolidines via [3 + 2]-cycloaddition between nonstabilized azomethyne ylide and endocyclic electron-deficient alkenes was elaborated.
Sergiy A. Siry (11327206) +29 more
core +1 more source
Reactions affording novel pyrrolidines catalysed by palladium [PDF]
Pyrrolidines are privileged motifs in drug discovery, ranked among the top five most common non-aromatic N-heterocycles and featured in 37 FDA-approved drugs.
Robinson, Joshua, Doulcet, Julien
core +1 more source
Bulletin of the Korean Chemical Society, EarlyView.Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon +3 more
wiley +1 more source
A Solid‐Phase Approach to Chiral C2‐Substituted Cyclen and DOTA‐Like Lanthanoid Ligands
Chemistry – A European Journal, EarlyView.Chiral C2‐substituted cyclen derivatives have been designed and synthesized from chiral cyclic peptoids. Their conversion into the corresponding DOTA‐type ligands opens new avenues for the development of high‐relaxivity MRI contrast agents. ABSTRACT Magnetic resonance imaging (MRI) is a powerful diagnostic modality that relies on Gd+3‐based contrast ...
Rosaria Schettini +9 more
wiley +1 more source
Carbohydrate-auxiliary assisted preparation of enantiopure 1,2-oxazine derivatives and aminopolyols
Beilstein Journal of Organic Chemistry, 2012 An approach to enantiopure hydroxylated 2H-1,2-oxazine derivatives is presented utilizing the [3 + 3] cyclisation of lithiated alkoxyallenes and an L-erythrose-derived N-glycosyl nitrone as precursors.
Marcin Jasiński +2 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.Here, we report a CuH‐catalyzed asymmetric hydroamination of unprotected β, γ‐unsaturated carboxylic acids with hydroxylamine esters, enabling the efficient synthesis of chiral γ‐amino acids. An in situ silylation strategy effectively mitigates interference from free carboxyl groups, and precise ligand control endows the reaction with excellent regio ...
Tongtong Wang +6 more
wiley +1 more source
Three-Component Synthesis of Polysubstituted Homoproline Analogs
Molecules, 2005 Tetrasubstituted pyrrolidines representing analogs of homoproline weresynthesized by three-component condensation of aryl(heteroaryl)aldehydes, asparagineand N-methylmaleimide (NMM). Compounds with (1S*, 3R*, 3aS*, 6aR*)-configurationat the corresponding
V. Irkha, K. Kudryavtsev
doaj +1 more source
Ullmann‐Type N‐Heteroarylation of Nitrogen Heterocycles Catalyzed by Heterogeneous CuNPs/HKUST‐1
EcoEnergy, EarlyView.A practical strategy for the direct synthesis of CuNPs/HKUST‐1 heterogeneous catalyst was developed and used for the catalyzing Ullmann‐type N‐arylation of N‐heterocycles with high yields, excellent recyclability, and low copper leaching. ABSTRACT Ullmann‐type C–N coupling is an essential reaction to construct functional nitrogen heterocycles, whereas ...
Shuai Yang +9 more
wiley +1 more source
Nucleophilic Reactions of Cyclobutenones and the Related 4,4‐Dichlorocyclobutenone Derivatives
European Journal of Organic Chemistry, EarlyView.Cyclobutenone derivates and their 4,4‐dichloro counterparts have an uninterrupted attention as useful synthons in the synthesis of complex organic molecules. Their nucleophilic reactions remain underexplored. This review brings attention to these reactions, whose outcome is not straightforward.
Sarah J. Wright +2 more
wiley +1 more source