Phosphorylated Nitrones—Synthesis and Applications [PDF]
MoleculesPhosphorylated nitrones belong to an important class of compounds with several applications, such as their therapeutic potency to reduce oxidative stress or as spin-trapping agents.
Iwona Rozpara +3 more
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Enantioselective formal (3 + 3) cycloaddition of bicyclobutanes with nitrones enabled by asymmetric Lewis acid catalysis [PDF]
Nature CommunicationsThe absence of catalytic asymmetric methods for synthesizing chiral (hetero)bicyclo[n.1.1]alkanes has hindered their application in new drug discovery.
Wen-Biao Wu +6 more
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Antioxidants, 2021 Synthetic nitrone spin-traps are being explored as therapeutic agents for the treatment of a wide range of oxidative stress-related pathologies, including but not limited to stroke, cancer, cardiovascular, and neurodegenerative diseases. In this context,
Stefania Marano +8 more
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Synthesis and Antioxidant Properties of Novel 1,2,3-Triazole-Containing Nitrones
Antioxidants, 2022 Herein, we report the synthesis and antioxidant capacity of twelve novel 1,2,3-triazole-containing nitrones such as N-(2-(4-aryl-1H-1,2,3-triazol-1-yl)ethylidene)methanamine oxides 8a–f and N-(2-(4-aryl)-1H-1,2,3-triazol-1-yl)ethylidene)-2-methylpropan-2-
Dimitra Hadjipavlou-Litina +3 more
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Nitrones: Comprehensive Review on Synthesis and Applications [PDF]
MoleculesNitrones are a significant class of compounds highly useful in organic synthesis; in particular, they are key intermediates for the synthesis of new biologically active nitrogen compounds.
Ricardo A. L. S. Santos +2 more
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Nitrones as therapeutics [PDF]
Free Radical Biology and Medicine, 2008 Nitrones have the general chemical formula X-CH=NO-Y. They were first used to trap free radicals in chemical systems and then subsequently in biochemical systems. More recently several nitrones, including alpha-phenyl-tert-butylnitrone (PBN), have been shown to have potent biological activity in many experimental animal models.
Richard D Kopke +2 more
exaly +3 more sources
Neuroprotective and Antioxidant Properties of CholesteroNitrone ChN2 and QuinolylNitrone QN23 in an Experimental Model of Cerebral Ischemia: Involvement of Necrotic and Apoptotic Cell Death [PDF]
Antioxidants, 2023 Ischemic stroke is the leading cause of disability and the second leading cause of death worldwide. However, current therapeutic strategies are scarce and of limited efficacy.
Beatriz Chamorro +6 more
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α-Phenyl-N-tert-Butylnitrone and Analogous α-Aryl-N-alkylnitrones as Neuroprotective Antioxidant Agents for Stroke [PDF]
AntioxidantsThe recent advances in research on the use of the antioxidant and neuroprotective agent α-phenyl-N-tert-butylnitrone (PBN) for the therapy of stroke have been reviewed. The protective effect of PBN in the transient occlusion of the middle cerebral artery
José Marco-Contelles
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In Vitro Modulation of Autophagy by New Antioxidant Nitrones as a Potential Therapeutic Approach for the Treatment of Ischemic Stroke [PDF]
AntioxidantsStroke is a leading cause of death worldwide, yet current therapeutic strategies remain limited. Among the neuropathological events underlying this disease are multiple cell death signaling cascades, including autophagy.
Sara Izquierdo-Bermejo +6 more
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