The Cellular and Organismal Effects of Nitroxides and Nitroxide-Containing Nanoparticles [PDF]
International Journal of Molecular SciencesNitroxides are stable free radicals that have antioxidant properties. They react with many types of radicals, including alkyl and peroxyl radicals. They act as mimics of superoxide dismutase and stimulate the catalase activity of hemoproteins. In some situations, they may exhibit pro-oxidant activity, mainly due to the formation of oxoammonium cations ...
Izabela Sadowska-Bartosz +2 more
exaly +4 more sources
The Effect of Piperidine Nitroxides on the Properties of Metalloproteins in Human Red Blood Cells [PDF]
Molecules, 2023 Nitroxides are stable, low molecular-weight radicals containing a nitroxide group that has an unpaired electron. The presence of a nitroxide group determines their redox properties.
Stella Bujak-Pietrek +3 more
doaj +2 more sources
Nitroxide-Based Contrast Agents for MRI Cancer Diagnostics: Progress, Limitations, and Perspectives [PDF]
MoleculesMagnetic resonance imaging (MRI) is one of the most powerful non-invasive methods for cancer diagnostics. To enhance image contrast and, therefore, diagnostic accuracy, contrast agents (CAs) are widely used in clinics.
Dmitry Mitin, Alexey Chubarov
doaj +2 more sources
Structural Features Governing the Metabolic Stability of Tetraethyl-Substituted Nitroxides in Rat Liver Microsomes [PDF]
Antioxidants, 2023 Nitroxides are potent tools for studying biological systems by electron paramagnetic resonance (EPR). Whatever the application, a certain stability is necessary for successful detection.
Aleksandra Rančić +3 more
doaj +2 more sources
Nitroxides: Chemistry, Antioxidant Properties, and Biomedical Applications [PDF]
MoleculesNitroxides are stable organic free radicals with a wide range of applications. They have found applications in chemistry, biochemistry, biophysics, molecular biology, and biomedicine as EPR/NMR imaging techniques. As spin labels and probes, they are used
Krzysztof Gwozdzinski +2 more
doaj +2 more sources
Molecules, 2022 Sterically shielded nitroxides, which demonstrate high resistance to bioreduction, are the spin labels of choice for structural studies inside living cells using pulsed EPR and functional MRI and EPRI in vivo.
Igor Kirilyuk +2 more
exaly +3 more sources
Modulation of the Human Erythrocyte Antioxidant System by the 5- and 6-Membered Heterocycle-Based Nitroxides [PDF]
MoleculesNitroxides are stable radicals consisting of a nitroxyl group, >N-O•, which carries an unpaired electron. This group is responsible for the paramagnetic and antioxidant properties of these compounds.
Krzysztof Gwozdzinski +3 more
doaj +2 more sources
Synthesis of sterically shielded piperidine nitroxides via acid-catalyzed heterocyclization of β-aminoketone derivatives with ketones [PDF]
Beilstein Journal of Organic ChemistryThe capabilities of modern methods for the synthesis of sterically shielded piperidine nitroxides with acyclic substituents are largely limited to symmetrical tetraethyl structures and do not allow the introduction of functional groups into position 2 ...
Mark M. Gulman +2 more
doaj +2 more sources
Nitric Oxide Donor Spermine-NONOate Elicits Endogenous Dispersal-Associated Transcriptional Responses to Promote Biofilm Dispersal in Pseudomonas aeruginosa [PDF]
AntibioticsBackground/Objectives: Bacterial biofilms are structured communities of sessile cells embedded in a self-produced extracellular matrix. Within biofilms, bacteria become highly tolerant toenvironmental stressors such as host immune responses and ...
Xavier Bertran Forga +3 more
doaj +2 more sources
Synthesis of tricyclic fused pyrrolidine nitroxides from 2-alkynylpyrrolidine-1-oxyls [PDF]
Beilstein Journal of Organic ChemistryRotational correlation time is a key parameter for organic radical contrast agents (ORCA) for magnetic resonance imaging (MRI). Design of polycyclic systems with incorporated nitroxide moieties in which rotation of the radical separately from the ...
Mark M. Gulman +6 more
doaj +2 more sources