Results 11 to 20 of about 2,106 (176)

Profluorescent Fluoroquinolone-Nitroxides for Investigating Antibiotic–Bacterial Interactions

Antibiotics, 2019
Fluorescent probes are widely used for imaging and measuring dynamic processes in living cells. Fluorescent antibiotics are valuable tools for examining antibiotic–bacterial interactions, antimicrobial resistance and elucidating antibiotic modes of
Anthony D Verderosa, Rabeb Dhouib, Kathryn Fairfull-Smith   +2 more
exaly   +3 more sources

Conformational tuning improves the stability of spirocyclic nitroxides with long paramagnetic relaxation times [PDF]

Communications Chemistry, 2023
Nitroxides are widely used as probes and polarization transfer agents in spectroscopy and imaging. These applications require high stability towards reducing biological environments, as well as beneficial relaxation properties.
Mateusz P. Sowiński, Sahil Gahlawat, Bjarte A. Lund, Anna-Luisa Warnke, Kathrin H. Hopmann, Janet E. Lovett, Marius M. Haugland   +6 more
doaj   +2 more sources

Redox-active nitroxides enhance cisplatin efficacy against cervical cancer [PDF]

Redox Biology
Cisplatin remains the primary treatment for most cervical cancer cases, though its clinical efficacy is hindered by dose-dependent toxicity and incurring chemoresistance.
Carl P. Soltau, Debottam Sinha, Lakshita P. Patil, Philip M. Moseley, Cassie L. Rayner, Nigel L. Barnett, Derek J. Richard, Steven E. Bottle, Ian H. Frazer, Alexander P. Martyn   +9 more
doaj   +2 more sources

Catalytic System for Cross-Coupling of Heteroaryl Iodides with a Nitronyl Nitroxide Gold Derivative at Room Temperature [PDF]

Molecules, 2023
A simple and highly effective methodology for the cross-coupling of heteroaryl iodides with NN–AuPPh3 at room temperature is reported. The protocol is based on a novel catalytic system consisting of Pd2(dba)3·CHCl3 and the phosphine ligand MeCgPPh having
Igor Zayakin, Galina Romanenko, Irina Bagryanskaya, Bogdan Ugrak, Matvey Fedin, Evgeny Tretyakov   +5 more
doaj   +2 more sources

2,5-Di-tert-butyl-2,5-diethylpyrrolidine-1-oxyls: Where Is a Reasonable Limit of Sterical Loading for Higher Resistance to Reduction? [PDF]

Molecules
The pyrrolidine nitroxides with four bulky alkyl substituents adjacent to the N–O∙ group demonstrate very high resistance to reduction with biogenic antioxidants and enzymatic systems.
Irina F. Zhurko, Sergey A. Dobrynin, Yurii I. Glazachev, Yuri V. Gatilov, Igor A. Kirilyuk   +4 more
doaj   +2 more sources

Cyclic Hydroxylamines as Monitors of Peroxynitrite and Superoxide-Revisited

Antioxidants, 2021
There is a considerable need for methods that allow quantitative determination in vitro and in vivo of transient oxidative species such as peroxynitrite (ONOOH/ONOO−) and superoxide (HO2•/O2•−).
Uri Samuni, Amram Samuni, Sara Goldstein
doaj   +1 more source

Amphiphilic branched polymer-nitroxides conjugate as a nanoscale agent for potential magnetic resonance imaging of multiple objects in vivo

Journal of Nanobiotechnology, 2021
Background In order to address the potential toxicity of metal-based magnetic resonance imaging (MRI) contrast agents (CAs), a concept of non-metallic MRI CAs has emerged. Currently, paramagnetic nitroxides (such as (2,2,5,5-tetramethylpyrrolidine-1-oxyl,
Xiaoming Wang, Shiwei Guo, Zhiqian Li, Qiang Luo, Yan Dai, Hu Zhang, Yun Ye, Qiyong Gong, Kui Luo   +8 more
doaj   +1 more source

A nitroxides-based macromolecular MRI contrast agent with an extraordinary longitudinal relaxivity for tumor imaging via clinical T1WI SE sequence

Journal of Nanobiotechnology, 2021
Background Macromoleculization of nitroxides has been an effective strategy to improve low relaxivities and poor in vivo stability, however, nitroxides-based metal-free magnetic resonance imaging (MRI) macromolecular contrast agents (mCAs) are still ...
Shiwei Guo, Xiaoming Wang, Zhiqian Li, Dayi Pan, Yan Dai, Yun Ye, Xiaohe Tian, Zhongwei Gu, Qiyong Gong, Hu Zhang, Kui Luo   +10 more
doaj   +1 more source

2-Butyl-2-tert-butyl-5,5-diethylpyrrolidine-1-oxyls: Synthesis and Properties

Molecules, 2020
Nitroxides are broadly used as molecular probes and labels in biophysics, structural biology, and biomedical research. Resistance of a nitroxide group bearing an unpaired electron to chemical reduction with low-molecular-weight antioxidants and enzymatic
Irina F. Zhurko, Sergey Dobrynin, Artem A. Gorodetskii, Yuri I. Glazachev, Tatyana V. Rybalova, Elena I. Chernyak, Nargiz Asanbaeva, Elena G. Bagryanskaya, Igor A. Kirilyuk   +8 more
doaj   +1 more source

3,4-Unsubstituted 2-tert-Butyl-pyrrolidine-1-oxyls with Hydrophilic Functional Groups in the Side Chains

Molecules, 2022
Pyrrolidine nitroxides with four bulky alkyl substituents adjacent to N–O group are known for their high resistance to bioreduction. The 3,4-unsubstituted 2-tert-butyl-2-ethylpyrrolidine-1-oxyls were prepared from the corresponding 2-tert-butyl-1 ...
Andrey I. Taratayko, Yurii I. Glazachev, Ilia V. Eltsov, Elena I. Chernyak, Igor A. Kirilyuk   +4 more
doaj   +1 more source