Results 1 to 10 of about 7,808 (189)

Synthesis of tricyclic fused pyrrolidine nitroxides from 2-alkynylpyrrolidine-1-oxyls [PDF]

Beilstein Journal of Organic Chemistry
Rotational correlation time is a key parameter for organic radical contrast agents (ORCA) for magnetic resonance imaging (MRI). Design of polycyclic systems with incorporated nitroxide moieties in which rotation of the radical separately from the ...
Mark M. Gulman, Yuliya F. Polienko, Sofia Yu. Trakhininа, Yuri V. Gatilov, Tatyana V. Rybalova, Sergey A. Dobrynin, Igor A. Kirilyuk   +6 more
doaj   +2 more sources

Synthesis and Evaluation of Ciprofloxacin-Nitroxide Conjugates as Anti-Biofilm Agents

Molecules, 2016
As bacterial biofilms are often refractory to conventional antimicrobials, the need for alternative and/or novel strategies for the treatment of biofilm related infections has become of paramount importance.
Robert D Hancock, Anthony D Verderosa, Cesar De La Fuente-Núñez   +2 more
exaly   +3 more sources

Nitroxide-Based Contrast Agents for MRI Cancer Diagnostics: Progress, Limitations, and Perspectives [PDF]

Molecules
Magnetic resonance imaging (MRI) is one of the most powerful non-invasive methods for cancer diagnostics. To enhance image contrast and, therefore, diagnostic accuracy, contrast agents (CAs) are widely used in clinics.
Dmitry Mitin, Alexey Chubarov
doaj   +2 more sources

Towards Metabolic Organic Radical Contrast Agents (mORCAs) for Magnetic Resonance Imaging [PDF]

Molecules
We report two conjugates of gem-diethyl pyrroline nitroxide radicals with D-mannosamine as potential metabolic organic radical contrast agents, mORCAs, circumventing the need for biorthogonal reactions.
Shuyang Zhang, Sabina Dhakal, Evan Curtis, Hunter Miller, Joseph T. Paletta, Connor Gee, Suchada Rajca, Forrest Kievit, Andrzej Rajca   +8 more
doaj   +2 more sources

2-Imidazoline Nitroxide Derivatives of Cymantrene

Molecules, 2022
The 2-imidazoline nitroxide derivatives of cymantrene—2-(η5-cyclopentadienyl)tricarbonylmanganese(I)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (NNMn) and 2-(η5-cyclopentadienyl)tricarbonylmanganese(I)-4,4,5,5-tetramethyl-4,5-dihydro-1H ...
Kseniya Maryunina, Gleb Letyagin, Galina Romanenko, Artem Bogomyakov, Vitaly Morozov, Sergey Tumanov, Sergey Veber, Matvey Fedin, Evgeniya Saverina, Mikhail Syroeshkin, Mikhail Egorov, Victor Ovcharenko   +11 more
doaj   +1 more source

Fluorinated Organic Paramagnetic Building Blocks for Cross-Coupling Reactions

Molecules, 2020
New stable polyfluorinated nitroxide radicals for use in cross-coupling reactions, namely, N-tert-butyl-N-oxyamino-2,3,5,6-tetrafluoro-4-iodobenzene and N-tert-butyl-N-oxyamino-2,3,5,6-tetrafluoro-4-ethynylbenzene, were prepared from perfluoroiodobenzene.
Larisa V. Politanskaya, Pavel A. Fedyushin, Tatyana V. Rybalova, Artem S. Bogomyakov, Nargiz B. Asanbaeva, Evgeny V. Tretyakov   +5 more
doaj   +1 more source

Inhibition of metastatic brain cancer in Sonic Hedgehog medulloblastoma using caged nitric oxide albumin nanoparticles

Frontiers in Oncology, 2023
Medulloblastoma is a tumor of the cerebellum that metastasizes to the leptomeninges of the central nervous system (CNS), including to forebrain and to spinal cord.
Bohdan J. Soltys, Katie B. Grausam, Shanta M. Messerli, Carleton J. C. Hsia, Haotian Zhao, Haotian Zhao, Haotian Zhao   +6 more
doaj   +1 more source

In Vitro Activities of Oxazolidinone Antibiotics Alone and in Combination with C-TEMPO against Methicillin-Resistant Staphylococcus aureus Biofilms

Antibiotics, 2023
Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a global health concern. The propensity of MRSA to form biofilms is a significant contributor to its pathogenicity.
Audrey R. N. Ndukwe, Jilong Qin, Sandra Wiedbrauk, Nathan R. B. Boase, Kathryn E. Fairfull-Smith, Makrina Totsika   +5 more
doaj   +1 more source

A Simple Method of Synthesis of 3-Carboxy-2,2,5,5-Tetraethylpyrrolidine-1-oxyl and Preparation of Reduction-Resistant Spin Labels and Probes of Pyrrolidine Series

Molecules, 2021
Stable free radicals are widely used as molecular probes and labels in various biophysical and biomedical research applications of magnetic resonance spectroscopy and imaging.
Sergey A. Dobrynin, Mikhail S. Usatov, Irina F. Zhurko, Denis A. Morozov, Yuliya F. Polienko, Yurii I. Glazachev, Dmitriy A. Parkhomenko, Mikhail A. Tyumentsev, Yuri V. Gatilov, Elena I. Chernyak, Elena G. Bagryanskaya, Igor A. Kirilyuk   +11 more
doaj   +1 more source

The Effect of Piperidine Nitroxides on the Properties of Metalloproteins in Human Red Blood Cells

Molecules, 2023
Nitroxides are stable, low molecular-weight radicals containing a nitroxide group that has an unpaired electron. The presence of a nitroxide group determines their redox properties.
Stella Bujak-Pietrek, Anna Pieniazek, Krzysztof Gwozdzinski, Lukasz Gwozdzinski   +3 more
doaj   +1 more source