Results 31 to 40 of about 4,555 (166)
Enantioselective Synthesis of Cyclic Nitrones and Oxime Ethers by Chemoselective Allylic Alkylation of Oximes [PDF]
, 2020 The enantio- and chemoselective iridium-catalyzed N- and O-allylation of oximes is described for the first time. Kinetic resolution in an intramolecular setting provides access to cyclic nitrones, oxime ethers and enantioenriched aliphatic allylic ...
Tobias, Sandmeier, Erick, Carreira
core +1 more source
Molecules, 2013 D-Glucopyranose-derived and L-idopyranose-derived piperidine nitrones were synthesized in good overall yields through six-step reaction sequence starting from readily available 2,3,4,6-tetra-O-benzyl-D-glucopyranose.
Chu-Yi Yu +4 more
doaj +1 more source
Results in Chemistry, 2021 Nitrones perform as aldehyde surrogates in the preparation of chalcones via mechanochemical activation under solvent free condition. Aldonitrones containing electron releasing and electron withdrawing substituent on the C-aryl group exhibit differential ...
Jesna Antony +3 more
doaj +1 more source
Highly Electron-Deficient Pyridinium-Nitrones for Rapid and Tunable Inverse-Electron-Demand Strain-Promoted Alkyne-Nitrone Cycloaddition to Bicyclo[6.1.0]nonyne [PDF]
, 2019 Highly accelerated inverse-electron-demand strain-promoted alkyne-nitrone cycloaddition (IED SPANC) between a sta- ble cyclooctyne (bicyclo[6.1.0]nonyne (BCN)) and nitrones delocalized into a Cα-pyridinium functionality is reported, with the ...
Alexander M., Polgar +4 more
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Antioxidants, 2023 Ischemic stroke is the leading cause of disability and the second leading cause of death worldwide. However, current therapeutic strategies are scarce and of limited efficacy.
Beatriz Chamorro +6 more
doaj +1 more source
Unexpected Reactivity of Nitrones: Catalytic Insertion of CS<sub>2</sub>. [PDF]
Org LettA new reactivity mode for nitrones is reported, consisting of the chloride-catalyzed insertion of CS(2) to afford thioamides. This reaction proceeds under metal-free and mild conditions, tolerates a broad family of substrates, and is robust and easily ...
López-Aguilar M +6 more
europepmc +2 more sources
Molecules, 2022 GM1 gangliosidosis is a rare lysosomal disease caused by the deficiency of the enzyme β-galactosidase (β-Gal; GLB1; E.C. 3.2.1.23), responsible for the hydrolysis of terminal β-galactosyl residues from GM1 ganglioside, glycoproteins, and ...
Francesca Clemente +8 more
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Nitrones: not only extraordinary spin traps, but also good nitric oxide sources in vivo
Acta Pharmaceutica, 2015 Free radicals are involved in the development of reperfusion injuries. Using a spin trap, the intensity of such lesions can be reduced. Nitrones (effective in vivo spin traps) were tried in this work as in vivo nitric oxide donors.
Croitoru Mircea Dumitru +8 more
doaj +1 more source
Synthetic studies of azulenyl and pseudoazulenyl nitrones [PDF]
, 2009 Free radicals have been implicated in various pathological conditions such as, stroke, aging and ischemic heart disease (IHD), as well as neurodegenerative diseases like Alzheimer’s, Parkinson’s, and Huntington’s disease.
Kolhe, Amolkumar
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Nitrones: a potential new alternative as therapeutic agents [PDF]
, 2017 Background: Nowadays, nitrones are the most used spin traps to characterize free radicals in biological systems due to the versatility and variety depending on the types of radicals to study and that the half-lives of the species studied and/or detected ...
Cerecetto, Hugo +11 more
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