Results 51 to 60 of about 12,240 (259)

Carbamoyl Anion Addition to Nitrones

, 2016
The addition of carbamoyl anions derived from N,N-disubstituted formamides and LDA to N-tert-butyl nitrones is described. The reaction was demonstrated with a variety of formamides and nitrones and provided a direct route to α-(N-hydroxy)­amino amides ...
Carl A. Busacca (1434076), Kaddy Camara (1789084), Chris H. Senanayake (1560043), Heewon Lee (1392817), Jonathan T. Reeves (1560049), Chris Lorenc (1789087), Zhibin Li (129098)   +6 more
core   +1 more source

Strategies Toward Accessing Enantioenriched (Hetero)Benzo‐Fused 5‐ and 6‐ Membered Rings via Intermolecular Carbometalation

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
The use of transition‐metal catalysts and design of chiral ligands have allowed chemists to access highly functionalized benzofused 5‐ and 6‐ membered rings in high yield and enantioselectivity. A common strategy used relies on an intermolecular carbometalation across alkynes and olefins, usually followed by a subsequent intramolecular carbometalation.
Clara Jans, Armaan Grewal, Xavier Abel‐Snape, Mark Lautens   +3 more
wiley   +2 more sources

Strain Release of 1‐Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs

Chemistry – A European Journal, EarlyView.
Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato, Philipp Natho, Marco Colella, Renzo Luisi   +3 more
wiley   +1 more source

Polyfunctionalized α-phenyl-tert-butyl(benzyl)nitrones [PDF]

, 2022
Nowadays, most stroke patients are treated exclusively with recombinant tissue plasminogen activator, a drug with serious side effects and limited therapeutic window. For this reason, and because of the known effects of oxidative stress on stroke, a more
López-Muñoz, Francisco, Hadjipavlou-Litina, Dimitra, Cristóbal de los Ríos, Bravo, I., Iriepa, Isabel, Stanislav Gobec, Iriepa Canalda, Isabel, Diez Iriepa, Daniel, Bravo, Isaac, Damijan Knez, Francisco López-Muñoz, Gobec, Stanislav, Isabel Iriepa, López Muñoz, Francisco, Ríos Salgado, Cristóbal de los, José Marco-Contelles, Diez-Iriepa, Daniel, Knez, Damijan, Dimitra Hadjipavlou-Litina, Marco-Contelles, José, Hadjipavlou Litina, Dimitra, de los Ríos, Cristóbal, Isaac Bravo, Marco Contelles, José Luis, Daniel Diez-Iriepa   +24 more
core   +1 more source

On the Question of Zwitterionic Intermediates in the [3 + 2] Cycloaddition Reactions between C-arylnitrones and Perfluoro 2-Methylpent-2-ene

Molecules, 2021
The molecular mechanism of the [3 + 2] cycloaddition reaction between C-arylnitrones and perfluoro 2-methylpent-2-ene was explored on the basis of DFT calculations. It was found that despite the polar nature of the intermolecular interactions, as well as
Katarzyna Mitka, Katarzyna Fela, Aleksandra Olszewska, Radomir Jasiński   +3 more
doaj   +1 more source

Synthesis and characterization of amphiphilic nitroxide 1,1,3,3–tetraethylisoindoline–2–oxyl–5–sodium sulfonate (TEIOSNa)

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract The synthesis and characterization of an amphiphilic nitroxide to be used as a controlling agent in a nitroxide‐mediated living radical polymerization in aqueous dispersion media is presented. In the first stage of nitroxide synthesis (phthalimide protection), two reaction methods were employed: traditional and microwave.
Enrique García‐Leal, Martha Eugenia Albores Velasco, René O. Vargas, Rubén Mil‐Martínez   +3 more
wiley   +1 more source

Synthetic studies of azulenyl and pseudoazulenyl nitrones

, 2009
Free radicals have been implicated in various pathological conditions such as, stroke, aging and ischemic heart disease (IHD), as well as neurodegenerative diseases like Alzheimer’s, Parkinson’s, and Huntington’s disease.
Kolhe, Amolkumar
core   +1 more source

RuO4-mediated oxidation of secondary amines: Part 1. Are hydroxylamines main intermediates? [PDF]

Journal of the Serbian Chemical Society, 2016
The RuO4-catalyzed oxidation of secondary amines Bn-NH-CH2R (1a-b; R=H, Me) gave mainly amides, but minute amounts of nitrones PhCH=N(O)-CH2R (9a-b) and traces of Bn-N(OH)-CH2R (R=H, 4a) were also detected.
Florea Cristina A., Petride Horia
doaj   +1 more source

Mechanistic and Reactivity Insights into Diboron‐Mediated NN and NN Bond Scission

European Journal of Organic Chemistry, EarlyView.
This review highlights the emerging ability of diboron reagents to cleave both π‐bonded (N=N) and σ‐bonded (N—N) nitrogen–nitrogen linkages, integrating mechanistic understanding with recent synthetic applications. Diboron reagents have emerged as versatile reducing agents capable of transforming a broad range of functional groups through pathways like
Raúl Valderrama‐Callejón, Inés Alonso, M. Belén Cid   +2 more
wiley   +1 more source

Synthesis and Neuroprotective Properties of N-Substituted C-Dialkoxyphosphorylated Nitrones

ACS Omega, 2019
Herein, we report the synthesis and neuroprotective power of some N-substituted C-(dialkoxy)phosphorylated nitrones 4a–g, by studying their ability to increase the cell viability, as well as their capacity to reduce necrosis and apoptosis.
D. Piotrowska, Laura Mediavilla, L. Cuarental, I. Głowacka, J. Marco-Contelles, D. Hadjipavlou-Litina, F. López-Muñoz, M. Oset-Gasque   +7 more
semanticscholar   +1 more source