Results 11 to 20 of about 1,162 (178)

A new role of N-arylbenzoquinoneimine N-oxides in the von Richter reaction [PDF]

Journal of the Serbian Chemical Society, 2006
The title nitrones react with cyanide ions to give benzoic acids and N-aryl-4-hydroxy-2-cyanophenylamines via two different pathways.
Karami Bahador, Damavandi Asgarin Jaffar, Bayat Maasomeh, Montazerozohori Monteza   +3 more
doaj   +3 more sources

Amidinoquinoxaline-Based Nitrones as Lipophilic Antioxidants

Antioxidants, 2021
The potential of nitrones (N-oxides) as therapeutic antioxidants is due to their ability to counteract oxidative stress, mainly attributed to their action as radical scavengers toward C- and O-centered radicals.
Nadia Gruber, Liliana Orelli, Cristina Minnelli, Luca Mangano, Emiliano Laudadio, Giovanna Mobbili, Pierluigi Stipa   +6 more
doaj   +1 more source

Insights into the Antioxidant Mechanism of Newly Synthesized Benzoxazinic Nitrones: In Vitro and In Silico Studies with DPPH Model Radical

Antioxidants, 2021
Synthetic nitrone spin-traps are being explored as therapeutic agents for the treatment of a wide range of oxidative stress-related pathologies, including but not limited to stroke, cancer, cardiovascular, and neurodegenerative diseases. In this context,
Stefania Marano, Cristina Minnelli, Lorenzo Ripani, Massimo Marcaccio, Emiliano Laudadio, Giovanna Mobbili, Adolfo Amici, Tatiana Armeni, Pierluigi Stipa   +8 more
doaj   +1 more source

SYNTHESIS AND CHARACTERIZATION OF SOME NEW NITRONES DERIVATIVES AND SCREENING THEIR BIOLOGICAL ACTIVITIES

Science Journal of University of Zakho, 2023
Synthetic approached towards the synthesis of some novel nitrones derivatives have been started with reduction of nitrobenzene derivatives as starting material bearing electron withdrawing and electron donating groups to corresponding ...
Jihad Haji Mohammed, Nabaz Abdulmajeed Mohammad Salih   +1 more
doaj   +1 more source

Synthesis and Characterization of Some New Nitrones Derivatives and Screening their Biological Activities

Science Journal of University of Zakho, 2022
Synthetic approached towards the synthesis of some novel nitrones derivatives have been started with reduction of nitrobenzene derivatives as starting material bearing electron withdrawing and electron donating groups to corresponding phenylhydroxylamine
Jihad Haji Mohammed, Nabaz Abdulmajeed Mohammad Salih   +1 more
doaj   +1 more source

3,4-Unsubstituted 2-tert-Butyl-pyrrolidine-1-oxyls with Hydrophilic Functional Groups in the Side Chains

Molecules, 2022
Pyrrolidine nitroxides with four bulky alkyl substituents adjacent to N–O group are known for their high resistance to bioreduction. The 3,4-unsubstituted 2-tert-butyl-2-ethylpyrrolidine-1-oxyls were prepared from the corresponding 2-tert-butyl-1 ...
Andrey I. Taratayko, Yurii I. Glazachev, Ilia V. Eltsov, Elena I. Chernyak, Igor A. Kirilyuk   +4 more
doaj   +1 more source

Improving the Efficacy of Quinolylnitrones for Ischemic Stroke Therapy, QN4 and QN15 as New Neuroprotective Agents after Oxygen–Glucose Deprivation/Reoxygenation-Induced Neuronal Injury

Pharmaceuticals, 2022
In our search for new neuroprotective agents for stroke therapy to improve the pharmacological profile of the compound quinolylnitrone QN23, we have prepared and studied sixteen new, related and easily available quinolylnitrones.
José M. Alonso, Alejandro Escobar-Peso, Israel Fernández, Alberto Alcázar, José Marco-Contelles   +4 more
doaj   +1 more source

Synthesis and Antioxidant Properties of Novel 1,2,3-Triazole-Containing Nitrones

Antioxidants, 2022
Herein, we report the synthesis and antioxidant capacity of twelve novel 1,2,3-triazole-containing nitrones such as N-(2-(4-aryl-1H-1,2,3-triazol-1-yl)ethylidene)methanamine oxides 8a–f and N-(2-(4-aryl)-1H-1,2,3-triazol-1-yl)ethylidene)-2-methylpropan-2-
Dimitra Hadjipavlou-Litina, Iwona E. Głowacka, José Marco-Contelles, Dorota G. Piotrowska   +3 more
doaj   +1 more source

An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars

Molecules, 2013
D-Glucopyranose-derived and L-idopyranose-derived piperidine nitrones were synthesized in good overall yields through six-step reaction sequence starting from readily available 2,3,4,6-tetra-O-benzyl-D-glucopyranose.
Chu-Yi Yu, Yue-Mei Jia, Jian-She Zhu, Wen-Bo Zhao, Hui Zhao   +4 more
doaj   +1 more source

Aldonitrones as aldehyde surrogates in solvent free synthesis of chalcones under mechanochemical activation

Results in Chemistry, 2021
Nitrones perform as aldehyde surrogates in the preparation of chalcones via mechanochemical activation under solvent free condition. Aldonitrones containing electron releasing and electron withdrawing substituent on the C-aryl group exhibit differential ...
Jesna Antony, John P. Rappai, Kala Ramakrishnan, Rakesh Natarajan   +3 more
doaj   +1 more source