Phosphorylated Nitrones—Synthesis and Applications [PDF]
MoleculesPhosphorylated nitrones belong to an important class of compounds with several applications, such as their therapeutic potency to reduce oxidative stress or as spin-trapping agents.
Iwona Rozpara +3 more
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Nitrones: Comprehensive Review on Synthesis and Applications [PDF]
MoleculesNitrones are a significant class of compounds highly useful in organic synthesis; in particular, they are key intermediates for the synthesis of new biologically active nitrogen compounds.
Ricardo A. L. S. Santos +2 more
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Amidinoquinoxaline-Based Nitrones as Lipophilic Antioxidants [PDF]
Antioxidants, 2021 The potential of nitrones (N-oxides) as therapeutic antioxidants is due to their ability to counteract oxidative stress, mainly attributed to their action as radical scavengers toward C- and O-centered radicals.
Nadia Gruber +6 more
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α-Phenyl-N-tert-Butylnitrone and Analogous α-Aryl-N-alkylnitrones as Neuroprotective Antioxidant Agents for Stroke [PDF]
AntioxidantsThe recent advances in research on the use of the antioxidant and neuroprotective agent α-phenyl-N-tert-butylnitrone (PBN) for the therapy of stroke have been reviewed. The protective effect of PBN in the transient occlusion of the middle cerebral artery
José Marco-Contelles
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On the Question of the Regio-, Stereoselectivity and the Molecular Mechanism of the (3+2) Cycloaddition Reaction Between (Z)-C-Phenyl-N-alkyl(phenyl)nitrones and (E)-3-(Methylsulfonyl)-propenoic Acid Derivatives [PDF]
MoleculesIn this work, the regio- and stereochemistry as well as the molecular mechanism of the cycloaddition reaction of nitrones with (E)-3-(methylsulfonyl)-propenoic acid derivatives were analyzed based on ωb97xD/6-311G(d,p) quantum chemical calculations.
Martyna Ząbkowska +3 more
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Enantioselective formal (3 + 3) cycloaddition of bicyclobutanes with nitrones enabled by asymmetric Lewis acid catalysis [PDF]
Nature CommunicationsThe absence of catalytic asymmetric methods for synthesizing chiral (hetero)bicyclo[n.1.1]alkanes has hindered their application in new drug discovery.
Wen-Biao Wu +6 more
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In Vitro Modulation of Autophagy by New Antioxidant Nitrones as a Potential Therapeutic Approach for the Treatment of Ischemic Stroke [PDF]
AntioxidantsStroke is a leading cause of death worldwide, yet current therapeutic strategies remain limited. Among the neuropathological events underlying this disease are multiple cell death signaling cascades, including autophagy.
Sara Izquierdo-Bermejo +6 more
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PHOSPHONATED ISOXAZOLIDINYL NUCLEOSIDES, A NEW CLASS OF MODIFIED NUCLEOSIDES [PDF]
Euromediterranean Biomedical Journal, 2014 This review offers an overview of the synthesis of phosphonated isoxazolidinyl nucleosides, a new class of interesting and potentially antiviral/antitumor agents.
Salvatore Giofrè
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Frontiers in Cellular Neuroscience, 2021 Nitrones are potent antioxidant molecules able to reduce oxidative stress by trapping reactive oxygen and nitrogen species. The antioxidant potential of nitrones has been extensively tested in multiple models of human diseases. Sensorineural hearing loss
Isabel Varela-Nieto +11 more
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A new role of N-arylbenzoquinoneimine N-oxides in the von Richter reaction [PDF]
Journal of the Serbian Chemical Society, 2006 The title nitrones react with cyanide ions to give benzoic acids and N-aryl-4-hydroxy-2-cyanophenylamines via two different pathways.
Karami Bahador +3 more
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