Results 1 to 10 of about 5,308 (247)

Silica gel-assisted synthesis of benzo[b]thiophenes from o-(alkylsulfanyl)(ethynyl)benzenes

Results in Chemistry, 2022
A variety of 2-substituted benzo[b]thiophenes were prepared from o-(alkylsulfanyl)(ethynyl)benzenes in the presence of silica gel under thermal conditions. Tertiary alkyl-substituted sulfanyl derivatives gave good results.
Kozo Toyota, Hiroki Tanaka, Taisei Hanagasaki   +2 more
doaj   +1 more source

The Ethnopharmacological Uses, Metabolite Diversity, and Bioactivity of Rhaponticum uniflorum (Leuzea uniflora): A Comprehensive Review

Biomolecules, 2022
Rhaponticum uniflorum (L.) DC. (syn. Leuzea uniflora (L.) Holub) is a plant species of the Compositae (Asteraceae) family that is widely used in Asian traditional medicines in China, Siberia, and Mongolia as an anti-inflammatory and stimulant remedy ...
Daniil N. Olennikov
doaj   +1 more source

Synthetic thiophenes induce chromosomal damage and trigger apoptosis in human cancer cell lines

European Journal of Medicinal Chemistry Reports, 2022
Thiophenes are heterocyclic compounds containing a five-membered ring with sulphur as the heteroatom. This class of substances has been shown to have several biological activities, including specific anti-proliferative effects against some cancer cell ...
Filipe N. Franco, Júlia T. Oliveira, Kimberly B. Tecchio, Flaviana A. Santos, Moacyr J.B.M. Rêgo, Francisco J.B. Mendonça-Júnior, Maira G.R. Pitta, Michelly C. Pereira, Rosy I.M.A. Ribeiro, Vanessa J.S.V. Santos, Fabio V. Santos   +10 more
doaj   +1 more source

Synthesis, Molecular Docking Study, and Cytotoxic Activity against MCF Cells of New Thiazole–Thiophene Scaffolds

Molecules, 2022
Investigating novel compounds that may be useful in designing new, less toxic, selective, and potent breast anticancer agents is still the main challenge for medicinal chemists.
Sobhi M. Gomha, Sayed M. Riyadh, Bader Huwaimel, Mohie E. M. Zayed, Magda H. Abdellattif   +4 more
doaj   +1 more source

Thiophenes—Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors

Plants, 2022
Naturally, thiophenes represent a small family of natural metabolites featured by one to five thiophene rings. Numerous plant species belonging to the family Asteraceae commonly produce thiophenes.
Sabrin R. M. Ibrahim, Abdelsattar M. Omar, Alaa A. Bagalagel, Reem M. Diri, Ahmad O. Noor, Diena M. Almasri, Shaimaa G. A. Mohamed, Gamal A. Mohamed   +7 more
doaj   +1 more source

COMPUTER SIMULATION OF π – π INTERACTIONS OF TETRATHIOPHENE MOLECULES

Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов, 2021
The properties of the supramolecular organization of conjugated polymers strongly affect the mobility of charge carriers and, consequently, the properties of produced electronic devices based on them.
V.G. Alekseev, P.O. Baburkin, S.-H. Tung, P.V. Komarov   +3 more
doaj   +1 more source

Synthesis of Some Thienopyrimidine Derivatives

Molecules, 2006
Thioxothienopyrimidinones, alkylthio- and arylalkylthiothienopyrimidinones, thienopyrimidinones, thienopyrimidines a thienopyrimidinedione and a thienotriazolo- pyrimidinone were prepared from 2-amino-3-carboethoxy-4,5-disubstituted thiophenes and 2 ...
Hassan M. Al-Hazimi, Hanan A. S. Al-Blowy, Fatma E. M. El-Baih   +2 more
doaj   +1 more source

Synthesis and Anti‐Inflammatory Activity of 2‐Amino‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐Derived NRF2 Activators

ChemistryOpen, 2022
This is the first study investigating the nuclear factor (erythroid‐derived 2)‐like 2 (NRF2) activity of compounds containing a new scaffold, tetrahydrobenzo[b]thiophene.
Kit‐Kay Mak, Zhang Shiming, Dr. Ola Epemolu, Prof. Dr. Albena T. Dinkova‐Kostova, Dr. Geoffrey Wells, Dr. Irina G. Gazaryan, Dr. Raghavendra Sakirolla, Prof. Dr. Zulkefeli Mohd, Prof. Dr. Mallikarjuna Rao Pichika   +8 more
doaj   +1 more source

Palladium-Catalyzed Direct (Het)arylation Reactions of Benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole and 4,8-Dibromobenzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole)

Molecules, 2023
Palladium-catalyzed direct (het)arylation reactions of strongly electron-withdrawing tricyclic benzo[1,2-d:4,5-d′]bis([1,2,3]thiadiazole) and its 4,8-dibromo derivative were studied; the conditions for the selective formation of mono- and bis-aryl ...
Timofey N. Chmovzh, Timofey A. Kudryashev, Daria A. Alekhina, Oleg A. Rakitin   +3 more
doaj   +1 more source

Flavouring Group Evaluation 76 Revision 2 (FGE.76Rev2): Consideration of sulfur‐containing heterocyclic compounds, evaluated by JECFA, structurally related to thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev5

EFSA Journal, 2023
The Panel on Food Additives and Flavourings (FAF) was requested to consider the JECFA evaluations of 28 flavouring substances in the Flavouring Group Evaluation 76 (FGE.76Rev2). Twenty‐one of these substances have been considered in FGE.76Rev1.
EFSA Panel on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, Laurence Castle, Gisela Degen, Karl‐Heinz Engel, Paul J Fowler, Maria Jose Frutos Fernandez, Peter Fürst, Ursula Gundert‐Remy, Rainer Gürtler, Trine Husøy, Melania Manco, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens‐Berendsen, Matthew Wright, Romualdo Benigni, Claudia Bolognesi, Kevin Chipman, Eugenia Cordelli, Karin Nørby, Camilla Svendsen, Maria Carfí, Giorgia Vianello, Wim Mennes   +26 more
doaj   +1 more source