Results 1 to 10 of about 12,572 (245)

Thiazoles in Peptides and Peptidomimetics [PDF]

, 2015
The natural occurrence of the thiazole ring in chemistry and biology has inspired its widespread use in synthetic peptidomimetics as structural templates, biological probes, and pharmaceuticals. Thiazole can be viewed as a dehydrated cyclized derivative of cysteine, incorporated into peptide sequences through chemical synthesis or ribosomal ...
Mak, Jeffrey Y. W., Xu, Weijun, Fairlie, David P.   +2 more
openaire   +4 more sources

Synthesis and Antithrombotic Activity Determination of (2-Methyl-4-[4-methyl-2-(4-trifluoromethylphenyl)-thiazole-5-ylmethylsulfanyl]phenoxy)acetic Acid Derivatives

Тонкие химические технологии, 2019
The article proposes an approach for obtaining the derivatives of hetarylmethylthioaryloxyalcane PPARS/fi agonists containing sulfoxide and sulfone fragments in the linker, the parent compound for the synthesis being GSK-516 - (2-methyl-4-[4-methyl-2-(4 ...
D. V. Minin, S. V. Popkov, M. L. Burdeyny, V. M. Goncharov, S. V. Vasilevsky   +4 more
doaj   +1 more source

Biosynthesis of the Thiamin-Thiazole in Eukaryotes: Identification of a Thiazole Tautomer Intermediate [PDF]

Journal of the American Chemical Society, 2008
Thiamin thiazole biosynthesis in eukaryotes is still not completely understood. In this report, a late intermediate, tightly bound to the active site of the Saccharomyces cerevisiae thiazole synthase, was identified as an adenylated thiazole tautomer. The reactivity of this unusual compound was evaluated.
Abhishek, Chatterjee, Frank C, Schroeder, Christopher T, Jurgenson, Steven E, Ealick, Tadhg P, Begley   +4 more
openaire   +2 more sources

Synthesis, Molecular Docking Study, and Cytotoxic Activity against MCF Cells of New Thiazole–Thiophene Scaffolds

Molecules, 2022
Investigating novel compounds that may be useful in designing new, less toxic, selective, and potent breast anticancer agents is still the main challenge for medicinal chemists.
Sobhi M. Gomha, Sayed M. Riyadh, Bader Huwaimel, Mohie E. M. Zayed, Magda H. Abdellattif   +4 more
doaj   +1 more source

Synthesis and Antimicrobial Activity of Some New Thiadiazoles, Thioamides, 5-Arylazothiazoles and Pyrimido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines

Molecules, 2016
A novel series of 1,3,4-thiadiazoles, 5-arylazothiazoles and hexahydropyrimido-[4,5-d][1,2,4]triazolo[4,3-a]pyrimidines were synthesized via reaction of hydrazonoyl halides with each of alkyl carbothioates, carbothioamides and 7-thioxo-5,6,7,8 ...
Abdou O. Abdelhamid, Ibrahim E. El Sayed, Mohamed Z. Hussein, Mangoud M. Mangoud   +3 more
doaj   +1 more source

Synthesis, Molecular Docking, and Dynamic Simulation Targeting Main Protease (Mpro) of New, Thiazole Clubbed Pyridine Scaffolds as Potential COVID-19 Inhibitors

Current Issues in Molecular Biology, 2023
Many biological activities of pyridine and thiazole derivatives have been reported, including antiviral activity and, more recently, as COVID-19 inhibitors.
Adel Alghamdi, Amr S. Abouzied, Abdulwahab Alamri, Sirajudheen Anwar, Mukhtar Ansari, Ibrahim Khadra, Yasser H. Zaki, Sobhi M. Gomha   +7 more
doaj   +1 more source

Synthesis, In Vitro Evaluation and Molecular Docking Studies of Novel Thiophenyl Thiazolyl-Pyridine Hybrids as Potential Anticancer Agents

Molecules, 2023
Many literature reports revealed the anticancer activity of pyridine and thiazole derivatives, especially in lung cancer. Therefore, a new series of thiazolyl pyridines linked with thiophene moiety via hydrazone group was prepared by one-pot multi ...
Fayza O. Ashmawy, Sobhi M. Gomha, Magda A. Abdallah, Magdi E. A. Zaki, Sami A. Al-Hussain, Mohamed A. El-desouky   +5 more
doaj   +1 more source

Sirtuin 1-Activating Compounds: Discovery of a Class of Thiazole-Based Derivatives

Molecules, 2022
Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase implicated in various biological and pathological processes, including cancer, diabetes, and cardiovascular diseases.
Giulia Bononi, Valentina Citi, Margherita Lapillo, Alma Martelli, Giulio Poli, Tiziano Tuccinardi, Carlotta Granchi, Lara Testai, Vincenzo Calderone, Filippo Minutolo   +9 more
doaj   +1 more source

Utility of 3-Acetyl-6-bromo-2H-chromen-2-one for the Synthesis of New Heterocycles as Potential Antiproliferative Agents

Molecules, 2015
Coumarin derivatives containing pyrazolo[1,5-a]pyrimidine, tetrazolo[1,5-a]pyrimidine, imidazo[1,2-a]pyrimidine, pyrazolo[3,4-d]pyrimidine, 1,3,4-thiadiazoles and thiazoles were synthesized from 6-bromo-3-(3-(dimethylamino)acryloyl)-2H-chromen-2-one ...
Sobhi M. Gomha, Yasser H. Zaki, Abdou O. Abdelhamid   +2 more
doaj   +1 more source

Crystal Structure and Solid-State Packing of 4-Chloro-5H-1,2,3-dithiazol-5-one and 4-Chloro-5H-1,2,3-dithiazole-5-thione

Molecules, 2021
The crystal structure and solid-state packing of 4-chloro-5H-1,2,3-dithiazol-5-one and two polymorphs of 4-chloro-5H-1,2,3-dithiazole-5-thione were analyzed and compared to structural data of similar systems. These five-membered S,N-rich heterocycles are
Christos P. Constantinides, Maria Koyioni, Fadwat Bazzi, Maria Manoli, Daniel B. Lawson, Panayiotis A. Koutentis   +5 more
doaj   +1 more source