A review on bis-hydrazonoyl halides: Recent advances in their synthesis and their diverse synthetic applications leading to bis-heterocycles of biological interest [PDF]
Journal of Advanced Research, 2016 This review covers a summary of the literature data published on the chemistry of bis-hydrazonoyl halides over the last four decades. The biological activities of some of the bis-heterocyclic compounds obtained from these bis-hydrazonoyl halides are also
Ahmad Sami Shawali
exaly +4 more sources
New Route Synthesis of Thiadiazoles, Bisthiadiazoles, Thiadiazolotriazines, and Pyrazolothiadiazoles Based on Hydrazonoyl Halides and Dihydrazinylthiadiazole [PDF]
Molecules, 2017 Synthesis and characterization of new thiadiazoles, bisthiadiazoles from the reaction of mono- and di-hydrazonoyl halides with various hydrazinecarbodithioate derivatives were studied.
Abdelwahed R. Sayed, Shar Saad Al-Shihry
doaj +5 more sources
Design, Synthesis, and Biological Evaluations of Novel Azothiazoles Based on Thioamide [PDF]
Current Issues in Molecular Biology, 2022 Herein we studied the preparation of different thiazoles via the reaction of 2-(3,4-dimethoxybenzylidene)hydrazine-1-carbothioamide (1) with hydrazonoyl halides under base-catalyzed conditions.
Abdelwahed R. Sayed +4 more
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Synthesis and In Silico Study of Some New bis-[1,3,4]thiadiazolimines and bis-Thiazolimines as Potential Inhibitors for SARS-CoV-2 Main Protease [PDF]
Current Issues in Molecular Biology, 2022 A novel series of bis-[1,3,4]thiadiazolimines, and bis-thiazolimines, with alkyl linker, were synthesized through general routes from cyclization of 1,1′-(hexane-1,6-diyl)bis(3-phenylthiourea) and hydrazonoyl halides or α-haloketones, respectively ...
Sobhi M. Gomha +7 more
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Synthesis and Molecular Docking of Some Novel 3-Thiazolyl-Coumarins as Inhibitors of VEGFR-2 Kinase [PDF]
Molecules, 2023 One crucial strategy for the treatment of breast cancer involves focusing on the Vascular Endothelial Growth Factor Receptor (VEGFR-2) signaling system. Consequently, the development of new (VEGFR-2) inhibitors is of the utmost importance. In this study,
Tariq Z. Abolibda +4 more
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Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents [PDF]
Frontiers in Chemistry, 2022 A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst.
Latifah A. Alshabanah +5 more
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Utility of 3-(2-oxo-2H-chromen-3-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde in the synthesis of novel 1,3,4-thiadiazoles or 1,3-thiazoles and study their cytotoxic activity [PDF]
Scientific ReportsOne of the biggest causes of death around the world is cancer. Despite the development of a variety of chemotherapeutic drugs that stop excessive cell division, drug resistance remains a major obstacle to chemotherapy.
Anhar Abdel-Aziem, Abdou O. Abdelhamid
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Molecules, 2000 Pyrrolidino[3,4-c]pyrazoline and pyrazole derivatives were synthesized via reactions of a substituted hydrazonoyl bromide with N-arylmaleimides and active methylene reagents, respectively. Synthesized pyrazoles were reacted with hydrazine hydrate to give
Abdou Abdelhamid
exaly +3 more sources
Novel Thiadiazole-Based Molecules as Promising Inhibitors of Black Fungi and Pathogenic Bacteria: In Vitro Antimicrobial Evaluation and Molecular Docking Studies [PDF]
Molecules, 2022 Novel 1,3,4-thiadiazole derivatives were synthesized through the reaction of methyl 2-(4-hydroxy-3-methoxybenzylidene) hydrazine-1-carbodithioate and the appropriate hydrazonoyl halides in the presence of a few drops of diisopropylethylamine.
Huda R. M. Rashdan +4 more
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Synthesis, Anticancer Evaluation, and Molecular Docking of Novel Thiazolobenzimidazole–Thiazole Hybrids as Potent Colon Cancer Inhibitors [PDF]
ChemistryOpenIn this study, a series of novel benzimidazothiazole–thiazole hybrids is synthesized via the condensation of 2‐(1‐(3‐methylbenzoimidazo[2,1‐b]thiazol‐2‐yl)ethylidene)hydrazine‐1‐carbothioamide with various hydrazonoyl halides and α‐halo compounds ...
Bader Huwaimel +6 more
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