Results 11 to 20 of about 586 (203)

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads [PDF]

ChemistryOpen
A new class of pyrido[2,3‐d][1,2,4]triazolo[4,3‐a]pyrimidinones and pyrido[2,3‐d]thiazolo[3,2‐a]pyrimidinones was synthesized by reacting 5‐phenyl‐2‐thioxo‐2,3‐dihydropyrido[2,3‐d]pyrimidin‐4(1H)‐one with hydrazonoyl halides and α‐bromoketones via a ...
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
doaj   +3 more sources

Synthesis, Anticancer Evaluation, and Molecular Docking of Novel Thiazolobenzimidazole–Thiazole Hybrids as Potent Colon Cancer Inhibitors [PDF]

ChemistryOpen
In this study, a series of novel benzimidazothiazole–thiazole hybrids is synthesized via the condensation of 2‐(1‐(3‐methylbenzoimidazo[2,1‐b]thiazol‐2‐yl)ethylidene)hydrazine‐1‐carbothioamide with various hydrazonoyl halides and α‐halo compounds ...
Bader Huwaimel, Amr S. Abouzied, Magdi E. A. Zaki, Abdulwahab Alamri, Basant Farag, Saad Alqarni, Sobhi M. Gomha   +6 more
doaj   +3 more sources

Electrochemical synthesis of pyrazolines and pyrazoles via [3+2] dipolar cycloaddition [PDF]

Angewandte Chemie International Edition, Volume 62, Issue 9, February 20, 2023., 2023
Pyrazolines and pyrazoles are common and important motifs of pharmaceutical agents and agrochemicals. Herein, the first electrochemical approach for their direct synthesis from easily accessible hydrazones and dipolarophiles up to decagram scale is ...
Bär, Robin M., Ehler, Nicole, Herman, Antonia, Hofmann, Silja, Linden, Martin, Waldvogel, Siegfried R.   +5 more
core   +2 more sources

Controlling (E/Z)‐Stereoselectivity of −NHC=O Chlorination: Mechanism Principles for Wide Scope Applications [PDF]

Chemistry – A European Journal, Volume 30, Issue 60, October 28, 2024.
Organic halogen compounds are cornerstones of applied chemical sciences. Halogen substitution is a smart molecular design strategy adopted to influence reactivity, membrane permeability and receptor interaction.
Aoyama, H, Elgazar, AA, Maklad, RM, Moustafa, GAI   +3 more
core   +2 more sources

Reactions with Hydrazonoyl Halides. 31. Synthesis of Some New Pyrrolidino[3,4-c]pyrazolines, Pyrazoles, and Pyrazolo[3,4-d]pyridazines

Molecules, 2000
Pyrrolidino[3,4-c]pyrazoline and pyrazole derivatives were synthesized via reactions of a substituted hydrazonoyl bromide with N-arylmaleimides and active methylene reagents, respectively. Synthesized pyrazoles were reacted with hydrazine hydrate to give
Nagla A. Ahmed, Mohamed M. M. Sallam, Hussien F. Zohdi, Abdou O. Abdelhamid   +3 more
doaj   +3 more sources

Novel Thiadiazole-Based Molecules as Promising Inhibitors of Black Fungi and Pathogenic Bacteria: In Vitro Antimicrobial Evaluation and Molecular Docking Studies [PDF]

Molecules, 2022
Novel 1,3,4-thiadiazole derivatives were synthesized through the reaction of methyl 2-(4-hydroxy-3-methoxybenzylidene) hydrazine-1-carbodithioate and the appropriate hydrazonoyl halides in the presence of a few drops of diisopropylethylamine.
Huda R. M. Rashdan, Mohamad T. Abdelrahman, Ihsan A. Shehadi, Sara S. El-Tanany, Bahaa A. Hemdan   +4 more
doaj   +2 more sources

Reaction of Nitrilimines with Pyruvaldehyde Hydrazones: Synthesis and Antimicrobial Evaluation of Some New 1,2,4-Triazole Derivatives [PDF]

Journal of Chemistry, Volume 2015, Issue 1, 2015., 2015
A new series of 1,3,4,5,5‐pentasubstituted‐1,2,4‐triazoles (4a–j, 6a–j) have been synthesized by the 1,3‐dipolar cycloaddition of suitable nitrilimines 2 to pyruvaldehyde (2‐oxopropanal) hydrazones having (COPh, COOMe, COOEt, Me/Me, and Me/Ph) groups 3 and 5.
Hany M. Dalloul, Sevgi Kolaylı
core   +2 more sources

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin-Dependent Kinase 4 Inhibitors. [PDF]

ChemistryOpen
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Abolibda TZ, Al-Hussain SA, Farag B, El-Naggar M, Zaki MEA, Alhazmi ESA, Almohammadi ASM, Gomha SM.   +7 more
europepmc   +2 more sources

Concomitant colour polymorphs of (Z)-N-(4-fluorophenyl)-2-oxopropanehydrazonoyl chloride. [PDF]

Acta Crystallogr C Struct Chem
(Z)‐N‐(4‐Fluorophenyl)‐2‐oxopropanehydrazonoyl chloride forms concomitant colour polymorphs, namely, block‐shaped pale‐orange crystals of form I (space group P21/n, Z = 4) and needle‐shaped pale‐yellow crystals of form II (space group P21/c, Z = 4).The title compound, (Z)‐N‐(fluorophenyl)‐2‐oxopropanehydrazonoyl chloride, C9H8ClFN2O, was found to form ...
Müller L, Goddard R, Frohberg P, Seidel RW.   +3 more
europepmc   +2 more sources

Synthesis of new functionalized derivatives of indolo[2,3-e][1,2,4]-triazolo-[4,5-b]-1,2,4-triazine [PDF]

Journal of the Serbian Chemical Society, 2013
New functionalized 1,2,4-triazolo-[4,3-b]-1,2,4-triazino-[5,6-b]indole derivatives were synthesized via reaction of the hydrazonoyl halides with 5H-2,3-dihydro-1,2,4-triazino[5,6-b]indole-3-thione or its 3-methylthio derivative.
Gomha Sobhi M., Abdel-Aziz Hatem A.
doaj   +1 more source