Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads [PDF]
ChemistryOpenA new class of pyrido[2,3‐d][1,2,4]triazolo[4,3‐a]pyrimidinones and pyrido[2,3‐d]thiazolo[3,2‐a]pyrimidinones was synthesized by reacting 5‐phenyl‐2‐thioxo‐2,3‐dihydropyrido[2,3‐d]pyrimidin‐4(1H)‐one with hydrazonoyl halides and α‐bromoketones via a ...
Sobhi M. Gomha +6 more
doaj +3 more sources
Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin-Dependent Kinase 4 Inhibitors. [PDF]
ChemistryOpenA novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Abolibda TZ +7 more
europepmc +2 more sources
Concomitant colour polymorphs of (Z)-N-(4-fluorophenyl)-2-oxopropanehydrazonoyl chloride. [PDF]
Acta Crystallogr C Struct Chem(Z)‐N‐(4‐Fluorophenyl)‐2‐oxopropanehydrazonoyl chloride forms concomitant colour polymorphs, namely, block‐shaped pale‐orange crystals of form I (space group P21/n, Z = 4) and needle‐shaped pale‐yellow crystals of form II (space group P21/c, Z = 4).The title compound, (Z)‐N‐(fluorophenyl)‐2‐oxopropanehydrazonoyl chloride, C9H8ClFN2O, was found to form ...
Müller L +3 more
europepmc +2 more sources
Synthesis of new functionalized derivatives of indolo[2,3-e][1,2,4]-triazolo-[4,5-b]-1,2,4-triazine [PDF]
Journal of the Serbian Chemical Society, 2013 New functionalized 1,2,4-triazolo-[4,3-b]-1,2,4-triazino-[5,6-b]indole derivatives were synthesized via reaction of the hydrazonoyl halides with 5H-2,3-dihydro-1,2,4-triazino[5,6-b]indole-3-thione or its 3-methylthio derivative.
Gomha Sobhi M., Abdel-Aziz Hatem A.
doaj +1 more source
Reactions with Hydrazonoyl Halides. Part 21. Reinvestigation of the Reactions of Hydrazonoyl Bromides with 1,1-Dicyanothioacetanilide [PDF]
Journal of Chemical Research, 1999 The reaction of C-(benzoyl) -N- (phenyl) formohydrazonoyl bromide with 1,1-dicyanothioacetanilide was reinvestigated. The product was elucidated on the basis of elemental analysis, spectral data and alternative synthesis. Also, reaction of hydrazonoyl halides with different thioanilides were investigated.
Abdou O. Abdelhamid +2 more
openaire +1 more source
European Journal of Organic Chemistry, Volume 26, Issue 47, December 13, 2023., 2023 1,3‐dipolar cycloaddition of cyclic enones with 2,5‐disubstituted nitrile‐imines obtained by photochemical activation of 2,5‐diaryl substituted tetrazoles leads to the formation of novel pyrazoles and pyrazolines. Reactions can be monitored using UV‐vis absorption and emission measurements.
Chiraz Labassi +4 more
wiley +1 more source
Synthetic Routes to Imidates and Their Applications in Organic Transformation: Recent Progress
European Journal of Organic Chemistry, Volume 26, Issue 39, October 16, 2023., 2023 Imidates are important organic intermediates used in several synthetic transformations towards N‐heterocycles, natural products and metal complexes with a potential catalytic effect. Herein, the recent synthetic approaches and diverse applications of imidates were categorized and summarized.
Andriani G. Chaidali, Ioannis N. Lykakis
wiley +1 more source
Different Synthetic Methods for the Preparation of Triazolopyrimidines and their Biological Profile
ChemistrySelect, Volume 8, Issue 23, June 20, 2023., 2023 This review aims to give a broad overview of the synthetic methods, starting from aminotriazoles and pyrimidines, leading to heterocyclic systems containing the triazolopyrimidine ring and presenting the reactivity of these derivatives. Additionally, we have summarized the most important biological activities.
Achraf Hibot +4 more
wiley +1 more source
Electrochemical Synthesis of Pyrazolines and Pyrazoles via [3+2] Dipolar Cycloaddition
Angewandte Chemie International Edition, Volume 62, Issue 9, February 20, 2023., 2023 Electrochemically initiated [3 2] cycloaddition reactions of readily available and less toxic starting materials enable a facile synthesis of pyrazolines and pyrazoles. Application of a biphasic system and sodium iodide in a dual role as mediator and electrolyte allows for selective reactions with outstanding robustness towards scalability.
Martin Linden +5 more
wiley +1 more source
Synthetic Strategies to Access Fluorinated Azoles. [PDF]
European J Org ChemThis review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
El-Gaber MKA +4 more
europepmc +2 more sources