Results 21 to 30 of about 298 (164)

Synthesis, Characterization and Molecular Docking of Novel Bioactive Thiazolyl-Thiazole Derivatives as Promising Cytotoxic Antitumor Drug

Molecules, 2015
Reactions of ethylidenethiocarbohydrazide with hydrazonoyl halides gave 1,3-thiazole or 1,3,4-thiadiazole derivatives according to the type of hydrazonoyl halides.
Sobhi M. Gomha, Taher A. Salaheldin, Huwaida M. E. Hassaneen, Hassan M. Abdel-Aziz, Mohammed A. Khedr   +4 more
doaj   +1 more source

Synthesis, in-silico studies, and biological evaluation of some novel 3-thiazolyl-indoles as CDK2–inhibitors

Results in Chemistry, 2023
The essential enzyme cyclin-dependent kinase 2 (CDK2) is a promising target for anticancer drug development due to its pivotal role in regulating the cell cycle. This study aimed to synthesize novel 3-thiazolyl-indole derivatives and assess their ability
Sobhi M. Gomha, Magdi E.A. Zaki, Deepika Maliwal, Raghuvir R.S. Pissurlenkar, Mohamed S. Ibrahim, Maher Fathalla, Ahmed M. Hussein   +6 more
doaj   +1 more source

Synthesis of Some New 1,3,4-Thiadiazole, Thiazole and Pyridine Derivatives Containing 1,2,3-Triazole Moiety

Molecules, 2017
In this study, 1-(5-Methyl-1-(p-tolyl)-1H-1,2,3-triazol-4-yl)ethan-1-one, was reacted with Thiosemicarbazide, alkyl carbodithioate and benzaldehyde to give thiosemicarbazone, alkylidenehydrazinecarbodithioate and 3-phenylprop-2-en-1-one-1,2,3-triazole ...
Nadia A. Abdelriheem, Ali M. M. Mohamed, Abdou O. Abdelhamid   +2 more
doaj   +1 more source

Synthesis and Biological Evaluation of Thiazolyl-Ethylidene Hydrazino-Thiazole Derivatives: A Novel Heterocyclic System

Applied Sciences, 2021
The reaction of 2-(1-(2-(2-(4-methoxybenzylidene)hydrazinyl)-4-methylthiazol-5-yl)ethylidene)hydrazinecarbothioamide with a range of hydrazonoyl chlorides and α-halo-compounds yielded three new series of thiazole derivatives.
Laila A. Al-Mutabagani, Fathy M. Abdelrazek, Sobhi M. Gomha, Ali S. Hebishy, Mohamed S. Abdelfattah, Safaa M. Hassan, Abdelwahed R. Sayed, Mahmoud M. Elaasser   +7 more
doaj   +1 more source

A Novel Synthesis of 1,2,4-Triazolopteridines

Molecules, 2002
Reaction of 1,2-dihydro-2-thioxopteridin-4(3H)-one, 6,7-dimethyl-1,2-dihydro-2-thioxopteridin-4(3H)-one and 6,7-diphenyl-1,2-dihydro-2-thioxopteridin-4(3H)-one with hydrazonoyl halides affords the title compounds in good yields.
Hamdi M. Hassaneen, Manal A. Darwish, Tayseer A. Abdallah   +2 more
doaj   +1 more source

Hydrazonoyl Halides: Their Versatile Biological Activities

The Open Bioactive Compounds Journal, 2009
The various biological activities namely anthelmintic, antiarthropodal, antiviral, antimicrobial, herbicidal, antisarcoptic, acaricidal, insecticidal and miticidal activities exhibited by the hydrazonoyl halides are surveyed. Also, the uses of such halides as pesticides, weed controlling and antihypertensive agents as well as lipoxygenase and cyclo ...
Ahmad S.Shawali, Nevien A.Samy
openaire   +1 more source

Synthesis of New 3-Heteroarylindoles as Potential Anticancer Agents

Molecules, 2016
2-(3-(1H-Indol-3-yl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-substituted-5-(substituted diazenyl)thiazoles and 2-(1H-indol-3-yl)-9-substituted-4,7-disubstituted pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(7H)-ones were synthesized via reaction of ...
Abdou O. Abdelhamid, Sobhi M. Gomha, Nadia A. Abdelriheem, Saher M. Kandeel   +3 more
doaj   +1 more source

Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives

Molecules, 2016
A convenient synthesis of some novel bis-pyrrole derivatives via hydrazonoyl halides is described. Antimicrobial evaluation of some selected examples of the synthesized products was carried out.
Nabila Abdelshafy Kheder
doaj   +1 more source

Utility of 5-(furan-2-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide in the synthesis of heterocyclic compounds with antimicrobial activity

BMC Chemistry, 2019
Background Pyrazolines show different biological activities. In recent years, interest in the chemistry of hydrazonoyl halides has been renewed. 1,3,4-Thiadiazoles are one of the most common heterocyclic pharmacophores with a wide range of biological ...
Abdou O. Abdelhamid, Ibrahim E. El Sayed, Yasser H. Zaki, Ahmed M. Hussein, Mangoud M. Mangoud, Mona A. Hosny   +5 more
doaj   +1 more source

Synthesis of novel thiazole, pyranothiazole, thiazolo[4,5-b]pyridines and thiazolo[5′,4′:5,6]pyrano[2,3-d]pyrimidine derivatives and incorporating isoindoline-1,3-dione group

BMC Chemistry, 2019
Background Thiazole is a core structural motif presents in a wide range of natural products. Thiazole derivatives also have a wide range of medicinal and biological properties. Results The reaction of hydrazonoyl halides with 2-(1-(4-(1,3-dioxoisoindolin-
Mona A. Hosny, Yasser H. Zaki, Wafaa A. Mokbel, Abdou O. Abdelhamid   +3 more
doaj   +1 more source