Thiazoles inhibit reactive oxygen and nitrogen species mediated diabetes mellitus: integrated in vitro and in silico insights [PDF]
RSC AdvancesThiazole heterocycles, characterized by their unique combination of sulfur and nitrogen atoms, have emerged as versatile scaffolds in medicinal chemistry.
Hamid Aziz
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A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO2
Molecules, 2009 Structurally diverse thiazoles with electron-donating and electron-withdrawing groups were conveniently synthesized through manganese dioxide (MnO2) oxidation of the corresponding thiazolines.
Bin Fu +4 more
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Reactions of acryl thioamides with iminoiodinanes as a one-step synthesis of N-sulfonyl-2,3-dihydro-1,2-thiazoles [PDF]
Beilstein Journal of Organic ChemistryA one-step method has been developed for the preparation of 2,3-dihydro-2-sulfonyl-3,4,5-substituted 1,2-thiazoles by the reaction of acryl thioamides and iminoiodinanes.
Vladimir G. Ilkin +7 more
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HeliyonThe reaction of sulfamethoxazolehydrazonoyl chloride with thiosemicarbazones, bis-thiosemicarbazones, or 4-amino-3-mercapto-1,2,4-triazole in dioxane in the presence of triethylamine as a basic catalyst at reflux resulted in the regioselective synthesis ...
Ahmed H M Elwahy +2 more
exaly +3 more sources
Green Chemistry Letters and Reviews, 2021 In this article, we applied ultrasonic irradiation as an ecofriendly, green, efficient approach for the synthesis of a new 1,3-thiazoles and 1,3,4-thiadiazines under solvent-free conditions.
Anhar Abdel-Aziem
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A Modular Synthesis of C5-Sulfenyl Thiazoles via an Intermolecular Pummerer Rearrangement: An Underexplored Scaffold for Medicinal Chemistry. [PDF]
Angew Chem Int Ed EnglModular access to underexplored C5‐sulfenyl thiazoles via an intermolecular Pummerer rearrangement is reported. The methodology exhibits a broad functional group tolerance enabling the seamless design of trisubstituted thiazole cores bearing a sulfur handle for further elaboration.
Smy JL +5 more
europepmc +3 more sources
3-Phenylpropanal and citral in the multicomponent synthesis of novel thiopyrano[2,3-d]thiazoles
Results in Chemistry, 2022 A 3-phenylpropanal and citral were studied in the multicomponent reaction with the isorhodanine and maleimides (EDDA catalyst) with the aim of the novel thiopyrano[2,3-d]thiazoles synthesis.
Andrii Lozynskyi +6 more
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Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications. [PDF]
Angew Chem Int Ed EnglPhotolysis of cysteine phenacylsulfides bearing non‐conjugating electron‐withdrawing substituents leads to high conversions into cysteine thioaldehydes through a Norrish type‐II pathway. This methodology enabled the study of the aqueous reactivity of these important biosynthetic intermediates, which, depending on peptide sequence, pH and buffer ...
Karthika A +9 more
europepmc +3 more sources
Pyridin-2-ylthiazolothiazoles – Synthesis and photophysical properties
Results in Chemistry, 2021 Thiazolo[5,4-d]thiazoles are valuable materials for a range of technical and biological applications. They are used as chemosensors, electroluminescent materials, organic light-emitting diodes (OLEDs), in solar cells, in live-cell imaging, etc., and for ...
Ana F.R. Cerqueira +3 more
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Selected 5-amino-1-aryl-1H-1,2,3-triazole scaffolds as promising antiproliferative agents [PDF]
The Ukrainian Biochemical Journal, 2020 Development of a new effective drugs with low side effects and definite chemical characteristics needs indentification of bioactive scaffolds for further structural optimization.
N. Pokhodylo +3 more
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