Results 31 to 40 of about 12,572 (245)

The Synthesis of Novel 2-Hetarylthiazoles via the Stille Reaction

Журнал органічної та фармацевтичної хімії, 2023
A preparative approach to the synthesis of 2-hetaryl thiazoles has been developed via the interaction of halothiazoles with stannanes according to the Stille reaction. The most effective catalysts and reaction conditions have been found.
Dmytro O. Tarasenko, Volodymyr M. Kotliar   +1 more
doaj   +1 more source

Vergleich der Dissoziationskonstanten von 2-Amino-thiazol- und 2-Amino-oxazol-Derivaten

CHIMIA, 1973
A description is given for the synthesis by standard methods of 2-Amino-4-phenyl- and 2-Amino-5-phenyl-thiazoles having different para-substituents together with the 2-Amino-4-phenyl-oxazole analogues. The pKa-values were determined for the compounds in
U. Stauss, H.P. Härter, O. Schindler
doaj   +1 more source

Thiazole formation through a modified Gewald reaction

Beilstein Journal of Organic Chemistry, 2015
The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. 1,4-Dithiane-2,5-diol was used as the aldehyde precursor to give either 2-substituted thiazoles or 2 ...
Carl J. Mallia, Lukas Englert, Gary C. Walter, Ian R. Baxendale   +3 more
doaj   +1 more source

Synthesis, Molecular Docking Studies and In Silico ADMET Screening of New Heterocycles Linked Thiazole Conjugates as Potent Anti-Hepatic Cancer Agents

Molecules, 2021
Thiazoles are important scaffolds in organic chemistry. Biosynthesis of thiazoles is considered to be an excellent target for the design of novel classes of therapeutic agents.
Huda R. M. Rashdan, Mohamed El-Naggar, Aboubakr H. Abdelmonsef   +2 more
doaj   +1 more source

Nonnative Thiol and Aniline Methylation, Including Enantioselective Dithiol Desymmetrization, by Multicomponent Cobamide‐Dependent Methyltransferases Using Unactivated Methyl Donors

Angewandte Chemie, EarlyView.
Mixed MtaABC/MtgABC methyltransferase systems were developed for non‐native thiol and aniline methylation using the unactivated methyl donors methanol and glycine betaine. The platform enabled site‐selective and enantioselective methylation with turnover number up to 6000, representing the first enantioselective non‐native catalysis by cobamide ...
Amardeep Kumar, Osman Ishag Adam, Paras Gupta, Jared C. Lewis   +3 more
wiley   +2 more sources

Thiazoles from cysteinyl peptides

, 1978
Glutathione deriv. I underwent dehydrative cyclization to thiazoline II which was oxidized by NiO2 to thiazole III (R = Et, R1 = Ac) which was hydrolyzed to III (R = R1 = H), an amino acid deriv. from the mushroom Xerocomus subtomentosus.
Jordis, Ulrich, Evans, David L., Hecht, Sidney M., Minster, David K.   +3 more
core   +4 more sources

Aromatic Pummerer‐Promoted Stereospecific Cross‐Coupling of Thiazoles With Boronic Esters

Angewandte Chemie, EarlyView.
A lithiation–borylation–aromatic Pummerer (LiBAP) strategy enables stereospecific, C5‐selective C(sp2)–C(sp3) cross‐coupling of thiazoles with boronic esters. By using exocyclic sulfoxide activation to overcome the low nucleophilicity that frustrates SEAr‐type coupling, the method delivers enantioenriched alkylated thiazoles bearing a versatile C2 ...
Mark John P. Mandigma, Julien Lefranc, Louise Eagling, Jasper L. Tyler, Varinder K. Aggarwal   +4 more
wiley   +2 more sources

Harnessing Diazoketones for the Efficient Synthesis of 2,4-Disubstituted-(1,3)Thiazoles: Scalable and Versatile Approach to Important Heterocyclic Scaffolds [PDF]

This study presents a scalable one-pot synthesis of 2,4-disubstituted-(1,3)thiazoles using diazoketones with thiosemicarbazide or thiourea, achieving high yields across various substrates.
Hanna, Yakovleva, Ivan, Stadniy, Olexandr, Pashenko, Serhiy, Ryabukhin, Olesia, Volovenko, Alexander, Rozhenko, Dmytro, Volochnyuk, Viacheslav, Pendiukh   +7 more
core   +1 more source

SOLiD‐MaP: A Photoproximity Labeling Platform for Small Molecule Binding Site Mapping on RNA

Angewandte Chemie, EarlyView.
SOLiD‐MaP is a ligand‐directed photoproximity labeling strategy developed for RNA binding‐site analysis. Singlet oxygen‐mediated labeling creates a proximity‐dependent chemical footprint of bound small molecules on RNA. Coupling this chemistry with mutational profiling enables identification of the ligand‐binding region at nucleotide resolution ...
Lin L. Rietveld, Wei Wu, Filip M. Zawisza, Danny Incarnato, Zeshi Li   +4 more
wiley   +2 more sources

Atroposelective Pd(0)‐Catalyzed Direct Intermolecular C─H Arylation of Thiazole N‐Oxides Provides Access to Heterobiaryls

Angewandte Chemie, EarlyView.
An enantioselective Pd(0)‐catalysed arylation at the C4‐position of thiazole N‐oxides directly forges the atropochiral heterobiaryl axis. A tailored point‐ and axially chiral monodentate phosphine ensures high reactivities along with a tight stereocontrol.
Vitalii Smal, Nicolai Cramer
wiley   +2 more sources