Results 41 to 50 of about 9,832 (211)

N-Propargylamines: versatile building blocks in the construction of thiazole cores

Beilstein Journal of Organic Chemistry, 2017
Thiazoles and their hydrogenated analogues are not only key structural units in a wide variety of natural products but they also constitute important building blocks in medicinal chemistry.
S. Arshadi, E. Vessally, L. Edjlali, R. Hosseinzadeh-Khanmiri, E. Ghorbani-Kalhor   +4 more
doaj   +1 more source

Synthesis and Biological Evaluation of Bisthiazoles and Polythiazoles

Molecules, 2018
Small heterocyclic compounds containing nitrogen and sulfur atoms, such as thiazole derivatives, represent a significant class of organic azoles that exhibit promising bioactivities and have a great potential in medicinal and agricultural fields.
Mohammed A. Al-Omair, Abdelwahed R. Sayed, Magdy M. Youssef   +2 more
doaj   +1 more source

Synthesis of various fused pyrimidine rings with their pharmacological and antimicrobial evaluation [PDF]

Journal of the Serbian Chemical Society, 2014
Various fused pyrimidine such as furo[2,3-d]pyrimidine, triazolo[1,5-a]pyrimidine, tetrazolo[1,5-a]pyrimidine were synthesized from the reactions of thioxopyrimidine-6(1H)-ones with ethyl chloroacetate (under different reaction conditions ...
Mounir Salem A., Marzouk Magda I., Mahmoud Naglaa F.   +2 more
doaj   +1 more source

Wood Sawdust as a Low‐Cost Filler in Whole‐Tire Reclaimed Rubber: Mechanical Characterization and Factory‐Scale Cost Analysis

Journal of Applied Polymer Science, EarlyView.
Whole‐tire reclaimed rubber is upgraded with wood sawdust, a carpentry by‐product available at no cost, across loadings from 0 to 20 wt%. At 5 wt%, tensile strength, elongation, hardness, viscosity, and water absorption all stay within commercial specification, and real factory data show an annual production saving near $62,000 with no capital ...
Mohammed S. Matar, Faris Tarlochan, Sami E. Alkhatib, Abdullah Abdelhamid   +3 more
wiley   +1 more source

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, EarlyView.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

Highly Potent Fluorogenic Ligands for Triplex DNA: 5‐Substituted 2‐(Naphthalen‐2‐yl)‐4H‐Chromen‐4‐Ones

Chemistry – A European Journal, EarlyView.
5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran, Landy Gu, Krege M. Christison, Kalee Thao, Liang Xue   +4 more
wiley   +1 more source

Thiazoles in glycosylation reactions: Novel synthesis of thiazole thioglycosides

Heteroatom Chemistry, 2017
AbstractThis research reports a novel method for synthesizing new thiazole thioglycosides. This series of thiazole thioglycosides were designed by the reaction of potassium cyanocarbonimidodithioate 2 with benzoyl acetonitrile 3a and ethyl bromoacetate 3b in the presence of ethanol‐KOH to give the corresponding potassium 4‐amino‐5‐substituted‐thiazole ...
Mamdouh A. Abu‐Zaied, Galal H. Elgemeie   +1 more
openaire   +1 more source

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

Microwave-Assisted Synthesis and Characterization of Flavone–Thiazole–Aryl Hybrids with Potential Anticancer and Antiparasitic Activity

Scientia Pharmaceutica
Flavone–thiazole–aryl hybrid molecules based on 6-aminoflavone and 5-arylidene-4-aminothiazol-2(5H)-ones were synthesized and subjected to physicochemical and biological studies. Microwave-assisted synthesis was performed in two steps.
Stepan Sysak, Wojciech Szczolko, Marziyeh Raeispour, Malgorzata Kucinska, Pawel Bakun, Roman Lesyk, Philippe Grellier, Marek Murias, Tomasz Goslinski   +8 more
doaj   +1 more source

Synthesis and Structural Study of Iodonium Ylides Derived From 2‐Iodosylbenzenesulfonic Acid: Reagents for Preparation of Annulated Thiazoles

European Journal of Organic Chemistry, EarlyView.
New ylides of two different types were prepared by reaction of 2‐iodosylbenzenesulfonic acid with the corresponding 1,3‐cyclohexanediones under acidic or basic conditions. These compounds have a typical for iodonium ylides structure with the CIC angles 94.18° –97.25° and the IC bond distances between 2.08 and 2.13 Å.
Dmitry M. Noskov, Matvey K. Shurikov, Irina A. Mironova, Natalia S. Soldatova, Akira Yoshimura, Akio Saito, Mekhman S. Yusubov, Viкtor V. Zhdankin   +7 more
wiley   +1 more source