Results 61 to 70 of about 12,572 (245)

Annulative Synthesis of Thiazoles and Oxazoles from Alkenyl Sulfoxides and Nitriles via Additive Pummerer Reaction [PDF]

, 2019
Pummerer‐based annulation of alkenyl sulfoxides, mainly ketene dithioacetal monoxides (KDMs), with nitriles has been developed. By means of trifluoromethanesulfonic anhydride (Tf₂O) as an activator, additive Pummerer reaction and subsequent C−S‐bond ...
Mitsuki Hori, Keisuke Nogi, Aiichiro Nagaki, Hori, Mitsuki, Nagaki, Aiichiro, Yorimitsu, Hideki, Hideki Yorimitsu, Nogi, Keisuke   +7 more
core   +1 more source

Safety and efficacy of the feed additive 4‐methyl‐5‐vinylthiazole [15.018] belonging to chemical group 29 for all animal species (FEFANA asbl)

EFSA Journal, 2023
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of 4‐methyl‐5‐vinylthiazole [15.018] belonging to chemical group 29 (thiazoles, thiophene and thiazoline), when used as sensory ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Mojca Durjava, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Paul Brantom, Andrew Chesson, Johannes Westendorf, Paola Manini, Birgit Dusemund   +21 more
doaj   +1 more source

Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents

Molecules, 2017
In this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation.
Sobhi M. Gomha, Thoraya A. Farghaly, Yahia Nasser Mabkhot, Mohie E. M. Zayed, Amany M. G. Mohamed   +4 more
doaj   +1 more source

Microwave-Assisted Synthesis and Characterization of Flavone–Thiazole–Aryl Hybrids with Potential Anticancer and Antiparasitic Activity

Scientia Pharmaceutica
Flavone–thiazole–aryl hybrid molecules based on 6-aminoflavone and 5-arylidene-4-aminothiazol-2(5H)-ones were synthesized and subjected to physicochemical and biological studies. Microwave-assisted synthesis was performed in two steps.
Stepan Sysak, Wojciech Szczolko, Marziyeh Raeispour, Malgorzata Kucinska, Pawel Bakun, Roman Lesyk, Philippe Grellier, Marek Murias, Tomasz Goslinski   +8 more
doaj   +1 more source

Crystal structures of ethyl {2-[4-(4-isopropylphenyl)thiazol-2-yl]phenyl}carbamate and ethyl {2-[4-(3-nitrophenyl)thiazol-2-yl]phenyl}carbamate

Acta Crystallographica Section E: Crystallographic Communications, 2016
The title compounds, C21H22N2O2S (I) and C18H15N3O4S (II), are structural analogs of the alkaloid Thiosporine B. Both molecules adopt a near-planar V-shaped conformation, which is consolidated by intramolecular N—H...N and C—H...O hydrogen bonds.
Elena V. Sukhonosova, Sergey A. Sokov, Gennady I. Ostapenko, Alexander S. Bunev, Pavel V. Dorovatovskii, Yan V. Zubavichus, Victor N. Khrustalev   +6 more
doaj   +1 more source

Aza‐Büchner–Curtius–Schlotterbeck Reaction Enables Selective Construction of Quaternary Carbon Centers

Angewandte Chemie International Edition, EarlyView.
We introduce the Aza‐Büchner–Curtius–Schlotterbeck (ABCS) reaction: A mild, catalyst‐free method for homologating aryl imines. Diverging from the traditional BCS mechanism, the diazo intermediate undergoes selective C─C insertion to form an all‐carbon quaternary center.
Simon O. Angerer, Vincent George, Aryaman Pattanik, Gaia Carpentiero, Tereza Morcinková, Julia Rehbein, Burkhard König   +6 more
wiley   +1 more source

Fragment-sized thiazoles in fragment-based drug discovery campaigns

, 2022
Thiazoles exhibit a wide range of biological activities and therefore represent useful and attractive building blocks. To evaluate their usefulness and pinpoint their liabilities in fragment screening campaigns, we assembled a focused library of 49 ...
Hrast, Martina, Anže Meden, Proj, Matic, Meden, Anže, Knez, Damijan, Rok Frlan, Krištof Bozovičar, Stanislav Gobec, Martina Hrast, Katarina Grabrijan, Bozovičar, Krištof, Frlan, Rok, Matic Proj, Damijan Knez, Gobec, Stanislav, Grabrijan, Katarina   +15 more
core   +1 more source

Synthesis of 1,3,5-Triazepines and Benzo[f][1,3,5]triazepines and Their Biological Activity: Recent Advances and New Approaches

Molecules
This review article discusses the recent progress in synthesizing seven-membered ring 1,3,5-triazepine and benzo[f][1,3,5]triazepine derivatives. These derivatives can be either unsaturated, saturated, fused, or separated.
Ameen Ali Abu-Hashem, Othman Hakami, Nasser Amri, Yousef E. Mukhrish, Ahmed A. M. Abdelgawad   +4 more
doaj   +1 more source

Thiazole-Based Thiosemicarbazones: Synthesis, Cytotoxicity Evaluation and Molecular Docking Study

Drug Design, Development and Therapy, 2021
Sobhi M Gomha,1,2 Hyam A Abdelhady,2 Doaa ZH Hassain,2 Aboubakr H Abdelmonsef,3 Mohamed El-Naggar,4 Mahmoud M Elaasser,5 Huda K Mahmoud2 1Chemistry Department, Faculty of Science, Islamic University in Almadinah Almonawara, Almadinah Almonawara, 42351 ...
Gomha SM, Abdelhady HA, Hassain DZH, Abdelmonsef AH, El-Naggar M, Elaasser MM, Mahmoud HK   +6 more
doaj  

Eco-Friendly Synthesis, Characterization and Biological Evaluation of Some Novel Pyrazolines Containing Thiazole Moiety as Potential Anticancer and Antimicrobial Agents

Molecules, 2018
The one-pot synthesis of a series of pyrazoline derivatives containing the bioactive thiazole ring has been performed through a 1,3-dipolar cycloaddition reaction of N-thiocarbamoylpyrazoline and different hydrazonoyl halides or α-haloketones in the
Mastoura M. Edrees, Sraa Abu- Melha, Amirah M. Saad, Nabila A. Kheder, Sobhi M. Gomha, Zeinab A. Muhammad   +5 more
doaj   +1 more source