Results 51 to 60 of about 766 (143)
Frontiers in Cell and Developmental Biology, 2021 Reports of APOE4-associated neurovascular dysfunction during aging and in neurodegenerative disorders has led to ongoing research to identify underlying mechanisms.
Felecia M. Marottoli +8 more
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Clock Gene Nr1d1 Alleviates Retinal Inflammation Through Repression of Hmga2 in Microglia
Journal of Inflammation Research, 2021 Zhijie Wang,1,2 Yinhua Huang,1,2 Feixue Chu,3 Shangli Ji,2 Kai Liao,1,2 Zekai Cui,2 Jiansu Chen,1,2,4,5 Shibo Tang1,2,6 1Aier School of Ophthalmology, Central South University, Changsha, People’s Republic of China; 2Aier Eye Institute, Aier Eye Hospital ...
Wang Z +7 more
doaj
The role of SHP/REV-ERBα/CYP4A axis in the pathogenesis of alcohol-associated liver disease
JCI Insight, 2021 Alcohol-associated liver disease (ALD) represents a spectrum of histopathological changes, including alcoholic steatosis, steatohepatitis, and cirrhosis. One of the early responses to excessive alcohol consumption is lipid accumulation in the hepatocytes.
Zhihong Yang +13 more
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JCI Insight, 2021 Cigarette smoke (CS) is the main etiological factor in the pathogenesis of emphysema/chronic obstructive pulmonary disease (COPD), which is associated with abnormal epithelial-mesenchymal transition (EMT).
Qixin Wang +4 more
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Sensory Neuroscience, EarlyView.Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa +5 more
wiley +1 more source
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Background Circadian clock disruption has emerged as a relevant axis in cancer; however, the expression patterns and diagnostic relevance of BMAL1 and CLOCK in multiple myeloma (MM) remain insufficiently defined. Methods BMAL1 and CLOCK mRNA expression was quantified by RT‐qPCR in bone marrow samples from 46 newly diagnosed MM patients and 13 ...
Hamide Albayrak +6 more
wiley +1 more source
Med Research, Volume 2, Issue 2, Page 236-279, June 2026.ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang +22 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Angiotensin II (Ang II) regulates the expression of some core clock genes; excess Ang II leads to atherosclerosis advancement.
Shipeng Wang +7 more
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Molecular Clocks in Translational Roadmap for Circadian‐Based Therapeutics in Lung Diseases
The FASEB Journal, Volume 40, Issue 10, 31 May 2026.High‐amplitude circadian oscillations maintain lung immune and epithelial homeostasis. Chronic inflammation dampens peripheral clock amplitude, driving chronodisruption, barrier dysfunction, and remodeling. Clock‐targeted therapies re‐entrain the lung circadian clock, restore rhythmic immune resolution, and promote functional lung repair.
Kingshuk Panda +5 more
wiley +1 more source
Drug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley +1 more source