Results 71 to 80 of about 766 (143)

Spatiotemporal Dynamics of Central Nervous System Diseases: Advancing Translational Neuropathology via Single‐Cell and Spatial Multiomics

MedComm, Volume 6, Issue 9, September 2025.
Central nervous system (CNS) diseases are driven by spatiotemporally dynamic molecular networks. Single‐cell and spatial multiomics technologies dissect cellular heterogeneity, microenvironmental remodeling, and intercellular crosstalk. Integration of transcriptomic, epigenomic, proteomic, and metabolomic layers reveals disease‐associated regulatory ...
Mingkai Xia, Quan Liu, Wenli Zhang, Jinwen Ge, Zhigang Mei   +4 more
wiley   +1 more source

Annual Banned‐Substance Review 17th Edition—Analytical Approaches in Human Sports Drug Testing 2023/2024

Drug Testing and Analysis, Volume 17, Issue 8, Page 1417-1442, August 2025.
Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario  Thevis, Tiia  Kuuranne, Hans  Geyer   +2 more
wiley   +1 more source

Potential Significance of Targeting Ferroptosis for Intervention of Diabetic Cardiomyopathy

Journal of Diabetes, Volume 17, Issue 6, June 2025.
The pathophysiology of DCM encompasses insulin resistance and hyperglycemia‐induced metabolic alterations in cardiomyocytes, mitochondrial dysfunction and oxidative stress, cardiac lipotoxicity, dysregulation of immune responses, endoplasmic reticulum (ER) stress, impaired calcium handling, and activation of the renin‐angiotensin‐aldosterone system ...
Qian Lei, Burton B. Yang, Juanjuan Lyu
wiley   +1 more source

Biological Clock Rhythm Regulates Viral Resistance of Human Bodies [PDF]

E3S Web of Conferences
Virus has caused great distress to human health. Based on the lack of specific target sites and therapy of various viruses, this article highlights circadian rhythm, the biological clock that tells the body to do the correct thing according to the time ...
Li Xinbo
doaj   +1 more source

Pharmacological activation of REV-ERBs is lethal in cancer and oncogene induced senescence

Nature, 2018
The circadian clock imposes daily rhythms in cell proliferation, metabolism, inflammation and DNA damage response. Perturbations of these processes are hallmarks of cancer and chronic circadian rhythm disruption predisposes individuals to tumour ...
G. Sulli, Amy Rommel, Xiaojie Wang, Matthew J. Kolar, F. Puca, A. Saghatelian, M. Plikus, I. Verma, Satchidananda Panda   +8 more
semanticscholar   +1 more source

The REV‐ERB antagonist SR8278 modulates keratinocyte viability in response to UVA and UVB radiation

Photochemistry and Photobiology, Volume 100, Issue 6, Page 1864-1873, November/December 2024.
The cryptochrome (CRY) inhibitor KS15 and REV‐ERB antagonist SR8278 are small‐molecule modulators of the circadian clock, in which the core circadian protein BMAL1 plays a critical role in regulating the expression of clock‐controlled genes (CCGs).
William Cvammen, Michael G. Kemp
wiley   +1 more source

Exercise‐Induced cytokines, diet, and inflammation and their role in adipose tissue metabolism

Health Science Reports, Volume 7, Issue 9, September 2024.
Abstract Background Obesity poses a significant global health challenge, necessitating effective prevention and treatment strategies. Exercise and diet are recognized as pivotal interventions in combating obesity. This study reviews the literature concerning the impact of exercise‐induced cytokines, dietary factors, and inflammation on adipose tissue ...
Abdullah Muataz Taha Al‐Ibraheem, Al‐Tuaama Abdullah Zeyad Hameed, Mohammed Dheyaa Marsool Marsool, Hritvik Jain, Priyadarshi Prajjwal, Istevan Khazmi, Ridha Saad Nazzal, Hussein Mezher Hameed AL‐Najati, Baqer Hadi Yusur Kharibet Al‐Zuhairi, Maryam Razzaq, Zainab Baqir Abd, Ali Dheyaa Marsool Marsool, Abdulrahman Isam wahedaldin, Omniat Amir   +13 more
wiley   +1 more source

REV-ERBα Regulates TH17 Cell Development and Autoimmunity

Cell Reports, 2018
Summary: RORγt is well recognized as the lineage-defining transcription factor for T helper 17 (TH17) cell development. However, the cell-intrinsic mechanisms that negatively regulate TH17 cell development and autoimmunity remain poorly understood. Here,
Mohammed Amir, Sweena Chaudhari, Ran Wang, Sean Campbell, Sarah A. Mosure, Laura B. Chopp, Qun Lu, Jinsai Shang, Oliver B. Pelletier, Yuanjun He, Christelle Doebelin, Michael D. Cameron, Douglas J. Kojetin, Theodore M. Kamenecka, Laura A. Solt   +14 more
doaj   +1 more source

REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis

Nature Communications, 2018
The roles of Rev-erbα and circadian clock in colonic inflammation remain unclarified. Here we show colon clock genes (including Rev-erbα) are dysregulated in mice with DSS-induced colitis.
Shuai Wang, Yanke Lin, Xue Yuan, Feng Li, Lianxia Guo, Baojian Wu   +5 more
semanticscholar   +1 more source

Adropin: An endocrine link between the biological clock and cholesterol homeostasis

Molecular Metabolism, 2018
Objective: Identify determinants of plasma adropin concentrations, a secreted peptide translated from the Energy Homeostasis Associated (ENHO) gene linked to metabolic control and vascular function.
Sarbani Ghoshal, Joseph R. Stevens, Cyrielle Billon, Clemence Girardet, Sadichha Sitaula, Arthur S. Leon, D.C. Rao, James S. Skinner, Tuomo Rankinen, Claude Bouchard, Marinelle V. Nuñez, Kimber L. Stanhope, Deborah A. Howatt, Alan Daugherty, Jinsong Zhang, Matthew Schuelke, Edward P. Weiss, Alisha R. Coffey, Brian J. Bennett, Praveen Sethupathy, Thomas P. Burris, Peter J. Havel, Andrew A. Butler   +22 more
doaj   +1 more source