Results 81 to 90 of about 766 (143)

Integrated bioinformatics and interaction analysis to advance chronotherapies for mental disorders

Frontiers in Pharmacology
IntroductionRobust connections have been identified between the pathophysiology of mental disorders and the functioning of the circadian system. The overarching objective of this study was to investigate the potential for circadian rhythms to be ...
Apoorva Bhatnagar, Apoorva Bhatnagar, Gupta Raj, Sandip Das, Arpita Kannihali, Eerappa Rajakumara, Greg Murray, Sandipan Ray   +7 more
doaj   +1 more source

The disrupted molecular circadian clock of monocytes and macrophages in allergic inflammation

Frontiers in Immunology
IntroductionMacrophage dysfunction is a common feature of inflammatory disorders such as asthma, which is characterized by a strong circadian rhythm.Methods and resultsWe monitored the protein expression pattern of the molecular circadian clock in human ...
Julia Teppan, Juliana Schwanzer, Sonja Rittchen, Sonja Rittchen, Thomas Bärnthaler, Jörg Lindemann, Barsha Nayak, Bernhard Reiter, Bernhard Reiter, Petra Luschnig, Aitak Farzi, Akos Heinemann, Eva Sturm   +12 more
doaj   +1 more source

NETWORK PHARMACOLOGY AND MOLECULAR DOCKING TO ELUCIDATE THE POTENTIAL MECHANISM OF SR9009 AGAINST BREAST CANCER TARGETS

Breast Cancer (BC) is one of the most common malignant tumors. SR9009 [Ethyl 3-[[(4-chlorophenyl) methyl-[(5-nitrothiophen-2-yl) methyl] amino] methyl] pyrrolidine-1-carboxylate], a specific agonist of pyrrole derivatives has promising pharmaceutical agent and efficacy in treating several conditions including metabolic diseases such as obesity, bipolar,
openaire   +2 more sources

Rev-Erbα: A Chronobiological Approach to Inflammation and Lung Disease Management: A Comprehensive Review

Indian Journal of Pharmacy Practice
The circadian cellular clock partially reduces macrophage inflammatory response by interacting with the nuclear receptor Rev-erbα. Disruption of circadian rhythm can result in diabetes, metabolic issues and fibrosis.
Sayyed Mateen, A. Qureshi, Amit Sharma, Vikas Gupta   +3 more
semanticscholar   +1 more source

Mechanism of mitochondrial biogenesis regulated by PGC-1α/NR1D1 to increase the vulnerability of myocardial ischemia/reperfusion injury in diabetes.

Chinese Medical Journal
BACKGROUND Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates the expression of clock gene nuclear receptor subfamily 1 group D member 1 (NR1D1) and is closely related to diabetes mellitus and ischemic heart disease.
Jiahui Cui, Shan Gao, Lu Li, Xiaorui Jin, Wei-na Duan, Zhongyuan Xia, Zhen Qiu   +6 more
semanticscholar   +1 more source

Targeting REV-ERBα/BNIP3 axis attenuates pulmonary arterial hypertension by repressing mitophagy in mice. [PDF]

Nat Commun
Qiu L, Lu T, Zhang J, Liu M, Wang H, Li W, Ma C, Li S, Ren B, Wang Q, Fan F, Xu H, Zheng F, Guan Y, Zhang X, Yang G, Chen L.   +16 more
europepmc   +1 more source

Symbiotic exclusivity between CLOCK and TFPI2 drives stemness and immunosuppression in glioblastoma models. [PDF]

J Clin Invest
Zhou F, Pang L, Liu Y, Khan F, Chen P.
europepmc   +1 more source

Small-Molecule Modulation of the Circadian Clock in Cancer and Aging. [PDF]

Molecules
Abdo AN, Gabr M.
europepmc   +1 more source

STL1267 inhibits myofibroblast differentiation in a TGFβ1-driven human lung fibroblast model. [PDF]

Am J Physiol Cell Physiol
Prasad C, Huang SK, Burris TP, Sundar IK.   +3 more
europepmc   +1 more source

Chronobiology of neurotropic viruses: rhythmic viral entry and arrhythmic host clocks. [PDF]

Cell Discov
Zeng S, Zhang Q, Yang X, Lv L, Zhang Y, Zhang Z, Wang Q, Luo MH, Dorf M, Li S, Zhao L, Fu B.   +11 more
europepmc   +1 more source