Results 61 to 70 of about 766 (143)

Clock gene dysregulation in epilepsy: A systematic review

Epilepsia Open, Volume 11, Issue 1, Page 53-77, February 2026.
Abstract Objective Epileptic seizures show a rhythmic pattern, being more frequent at particular times of the day (e.g., only occurring during sleep), suggesting a role of the circadian rhythm. Clock genes regulate the circadian rhythm and might be involved in the pathophysiology of epilepsy.
Guilherme Fernandes‐Campos, Arjune Sen, Francesca Panin, Krithika Sundararaman   +3 more
wiley   +1 more source

Targeting Cryptochromes in Chronic Diseases

Cell Biology International, Volume 49, Issue 12, Page 1579-1590, December 2025.
ABSTRACT The circadian clock generates 24‐h molecular rhythms through transcription–translation negative feedback loops (TTFLs) and regulates daily physiological processes such as sleep–wake cycles, body temperature, hormone secretion, metabolism, and immune function.
Takuro Toda, Tsuyoshi Hirota
wiley   +1 more source

Melatonin Attenuates Dysregulation of the Circadian Clock Pathway in Mice With CCl4-Induced Fibrosis and Human Hepatic Stellate Cells

Frontiers in Pharmacology, 2018
Dysregulation of the circadian clock machinery is a critical mechanism in the pathogenesis of fibrosis. This study aimed to investigate whether the antifibrotic effect of melatonin is associated with attenuation of circadian clock pathway disturbances in
Bárbara González-Fernández, Diana I. Sánchez, Irene Crespo, Irene Crespo, Beatriz San-Miguel, Juan Ortiz de Urbina, Javier González-Gallego, Javier González-Gallego, María J. Tuñón, María J. Tuñón   +9 more
doaj   +1 more source

Circadian Rhythm: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 11, November 2025.
This review offers a comprehensive overview of the mechanisms by which circadian rhythms modulate tissue homeostasis, alongside the associations between circadian disturbances and circadian rhythm‐related diseases. Furthermore, we offer insights into circadian rhythm‐regulating therapies, which may contribute to the development of novel strategies for ...
Kangkang Zha, Bobin Mi, Yuan Xiong, Shuyan Wu, Li Lu, Shengming Zhang, Xuan Lu, Hei Chung Mak, Jianping Huang, Adriana C. Panayi, Samuel Knoedler, Lili Chen, Guohui Liu, Sien Lin   +13 more
wiley   +1 more source

LC-HRMS-Based Metabolic Profiling of the REV-ERB Agonist SR9009 in Camel Liver Homogenate and Cunninghamella elegans for Anti-Doping Analysis.

Rapid Communications in Mass Spectrometry
RATIONALE SR9009 is a synthetic REV-ERB agonist with potential performance-enhancing properties and is included on the World Anti-Doping Agency (WADA) Prohibited List for human sport.
Ansar Babu Palathinkal, S. Farook Basha, Saraswathy Laya, J. Nalakath, O. K. Praseen, Marina Joseph, Shantymol V Jose   +6 more
semanticscholar   +1 more source

Circadian clock molecule REV-ERBα regulates lung fibrotic progression through collagen stabilization

Nature Communications, 2023
Molecular clock REV-ERBα is central to regulating lung injuries, and decreased REV-ERBα abundance mediates sensitivity to pro-fibrotic insults and exacerbates fibrotic progression.
Qixin Wang, I. Sundar, J. Lucas, Jun-Gyu Park, A. Nogales, L. Martínez-Sobrido, I. Rahman   +6 more
semanticscholar   +1 more source

Ferritinophagy Is Involved in the Advanced Glycation End Products‐Induced Ferroptosis of Vascular Endothelial Cells in Diabetes Mellitus

Journal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.
ABSTRACT This study investigated the role of advanced glycation end products (AGEs) and ferritinophagy‐dependent ferroptosis in the pathogenesis of diabetic atherosclerosis obliterans. We investigated the effects of AGEs on ferroptosis and ferritinophagy in HUVECs.
Yi Huang, Yongzhi Jin, Junsheng Hu, Mengfan Li, Ming Tian, Guang Zeng, Rong Huang   +6 more
wiley   +1 more source

An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain

Journal of Neuroinflammation, 2019
Background Disturbances in clock genes affect almost all patients with Alzheimer’s disease (AD), as evidenced by their altered sleep/wake cycle, thermoregulation, and exacerbation of cognitive impairment. As microglia-mediated neuroinflammation proved to
Junjun Ni, Zhou Wu, Jie Meng, Takashi Saito, Takaomi C. Saido, Hong Qing, Hiroshi Nakanishi   +6 more
doaj   +1 more source

Circadian control of the secretory pathway maintains collagen homeostasis

Nature Cell Biology, 2020
Collagen is the most abundant secreted protein in vertebrates and persists throughout life without renewal. The permanency of collagen networks contrasts with both the continued synthesis of collagen throughout adulthood and the conventional ...
Joan Chang, Richa Garva, A. Pickard, C. Yeung, V. Mallikarjun, J. Swift, D. Holmes, Ben C. Calverley, Yinhui Lu, A. Adamson, Helena Raymond-Hayling, Oliver E. Jensen, Tom Shearer, Q. Meng, K. Kadler   +14 more
semanticscholar   +1 more source

Circadian Clock: A Regulator of Immunity in Autoimmune Diseases

Immunity, Inflammation and Disease, Volume 13, Issue 9, September 2025.
This review explores the intricate connections between circadian clocks and immune responses in autoimmune diseases. We aim to open new avenues for therapeutic interventions, including chronotherapy and targeting clock genes, with the potential to improve treatment outcomes in autoimmune diseases.
Ye‐Jun Wu, Shu‐Ying Zhang, Hong‐Yu Chen, Xin‐Ran He, Guang‐Rui Yang   +4 more
wiley   +1 more source