Results 1 to 10 of about 36,406 (125)

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice [PDF]

Gastroenterology, 2018
The innate immune system responds not only to bacterial signals, but also to non-infectious danger-associated molecular patterns that activate the NLRP3 inflammasome complex after tissue injury. Immune functions vary over the course of the day, but it is not clear whether these changes affect the activity of the NLRP3 inflammasome.
Pourcet, Benoit, Zecchin, Mathilde, Ferri, Lise, Beauchamp, Justine, Sitaula, Sadichha, Billon, C., Delhaye, Stéphanie, Vanhoutte, Jonathan, Mayeuf-Louchart, Alicia, Thorel, Quentin, Haas, Joël, Eeckhoute, Jérôme, Dombrowicz, David, Duhem, Christian, Boulinguiez, Alexis, Lancel, Steve, Sebti, Yasmine, Burris, Thomas P., Staels, Bart, Duez, Hélène   +19 more
openaire   +4 more sources

Nuclear receptor subfamily 1 group D member 1 suppresses the proliferation, migration of adventitial fibroblasts, and vascular intimal hyperplasia via mammalian target of rapamycin complex 1/β-catenin pathway

Clinical and Experimental Hypertension, 2023
Background In-stent restenosis hardly limits the therapeutic effect of the percutaneous vascular intervention. Although the restenosis is significantly ameliorated after the application of new drug-eluting stents, the incidence of restenosis remains at a
Ke Peng, Mingliang Wang, Jun Wang, Qiang Wang, De Li, Xiongshan Sun, Yongjian Yang, Dachun Yang   +7 more
doaj   +3 more sources

Nuclear receptor subfamily 1 group D member 2 induces chemoresistance in ovarian cancer by regulating ferroptosis and immune infiltration

Discover Oncology
Ovarian cancer is known for its high recurrence rates and poor prognosis, primarily due to chemoresistance, which significantly limits treatment options.
Linlin Wang, Ning Shao, Yaoyu Qu, Huizhen Sun, Jin Zhao   +4 more
doaj   +3 more sources

Effects of circadian rhythms on antimicrobial peptide concentrations in lactating goat milk [PDF]

BMC Veterinary Research
Background Immune system is regulated by circadian rhythms, which promote inflammation and facilitate pathogen elimination. Antimicrobial peptides secreted by milk somatic cells and mammary gland epithelial cells play a crucial role in protecting the ...
Zi-Long Liang, Takahiro Nii, Toshihisa Sugino, Naoki Isobe   +3 more
doaj   +2 more sources

P2X7R deficiency alleviates cardiac senescence by enhancing mitophagy via the HuR/TRIM26/NR4A1 axis [PDF]

Clinical and Translational Medicine
Background Ageing is a significant risk factor for pathophysiological alterations in the heart, but the intrinsic mechanisms by which these occur have yet to be fully elucidated.
Yixin Zhou, Xin Zhong, Zhijie Mao, Yunxuan Chen, Jincheng Xing, Jiaxu Shen, Wenli Zhang, Ji Zhang, Jiaxuan Mei, Zhentong Yang, Zhuoqun Wang, Bozhi Ye, Jiahui Lin, Yonghua Wang, Zhouqing Huang   +14 more
doaj   +2 more sources

Effect of Ramadan Fasting on Malondialdehyde, Poly (ADP-Ribose) Polymerase, Sirtuin 1, Nuclear Receptor Subfamily 1 Group D Member 1, and Transforming Growth Factor Beta in Chronic Kidney Disease: A Prospective Cohort Study

Acta Medica Indonesiana
Background: Chronic kidney disease (CKD) is a global health problem with increasing prevalence. This study aims to analyze the effect of Ramadan fasting on important biomarkers in CKD patients. Methods: A prospective cohort study was conducted on 30 CKD
Drajad Priyono, Eti Yerizel, Harnavi Harun, Netti Suharti   +3 more
doaj   +2 more sources

Transcriptomic Analysis Reveals Circadian Rhythm Homeostasis in Pearl Gentian Grouper under Acute Hypoxia

Fishes, 2023
Oxygen level is an important environmental factor affecting the circadian rhythm. However, little is known about the molecular mechanism by which clock genes regulate the circadian rhythm in fish under hypoxia. To explore changes in the transcription and
Ren-Xie Wu, Yan-Shan Liang, Su-Fang Niu, Jing Zhang, Bao-Gui Tang, Zhen-Bang Liang   +5 more
doaj   +1 more source

One Bout of Aerobic Exercise Can Enhance the Expression of Nr1d1 in Oxidative Skeletal Muscle Samples

Frontiers in Physiology, 2021
The nuclear receptor subfamily 1, group D member 1 (Nr1d1), plays a role in the skeletal muscle’s oxidative capacity, mitochondrial biogenesis, atrophy genes, and muscle fiber size.
Rafael L. Rovina, Alisson L. da Rocha, Bruno B. Marafon, José R. Pauli, Leandro P. de Moura, Dennys E. Cintra, Eduardo R. Ropelle, Adelino S. R. da Silva, Adelino S. R. da Silva   +8 more
doaj   +1 more source

Maternal intake restriction programs the energy metabolism, clock circadian regulator and mTOR signals in the skeletal muscles of goat offspring probably via the protein kinase A-cAMP-responsive element-binding proteins pathway

Animal Nutrition, 2021
The biological mechanism by which maternal undernutrition increases the metabolic disorder risk of skeletal muscles in offspring is not fully understood. We hypothesize that maternal intake restriction influences metabolic signals in the skeletal muscles
Xiaoling Zhou, Qiongxian Yan, Hong Yang, Ao Ren, Zhixiong He, Zhiliang Tan   +5 more
doaj   +1 more source

Targeting NR1D1 in organ injury: challenges and prospects

Military Medical Research, 2023
Nuclear receptor subfamily 1, group D, member 1 (NR1D1, also known as REV-ERBα) belongs to the nuclear receptor (NR) family, and is a heme-binding component of the circadian clock that consolidates circadian oscillators.
Zi-Yin Zhang-sun, Xue-Zeng Xu, Germaine Escames, Wang-Rui Lei, Lin Zhao, Ya-Zhe Zhou, Ye Tian, Ya-Nan Ren, Darío Acuña-Castroviejo, Yang Yang   +9 more
doaj   +1 more source