Results 1 to 10 of about 4,156 (159)

Role of NR1D1 in Bisphenol A-Induced Anxiety-like Behavior and Inflammation in Zebrafish Larvae [PDF]

Toxics
Bisphenol A (BPA) is a widespread environmental endocrine disruptor with significant neurodevelopmental and behavioral risks. The present study explored the role of the circadian clock protein NR1D1 in mediating BPA-induced anxiety-like behavior and ...

exaly   +6 more sources

The combination of nuclear receptor NR1D1 and ULK1 promotes mitophagy in adipocytes to ameliorate obesity

Adipocyte, 2022
Obesity is a severe disease worldwide. Mitochondrial autophagy (mitophagy) may be related to metabolic abnormalities in obese individuals, but the mechanism is still unclear.
Bo Yu, Jin-Bao Pan, Fei-Yue Yu
exaly   +5 more sources

Sleep Disturbance Induces Increased Cholesterol Level by NR1D1 Mediated CYP7A1 Inhibition [PDF]

Frontiers in Genetics, 2020
Disturbed sleep is closely associated with an increased risk of metabolic diseases. However, the underlying mechanisms of circadian clock genes linking sleep and lipid profile abnormalities have not been fully elucidated.
Lun Song, Chongchong Zhang, Chen Xing
exaly   +5 more sources

Effect of NR1D1 on the proliferation and differentiation of yak skeletal muscle satellite cells

Frontiers in Veterinary Science
The severe conditions at high altitudes, where yaks inhabit, contribute to delayed muscular growth and compromised tenderness of their muscle tissue. Myosatellite cells are responsible for the growth and regeneration of skeletal muscle after birth and ...
Jincheng Zhong, Xin Jinwei
exaly   +5 more sources

Adipocyte NR1D1 dictates adipose tissue expansion during obesity

eLife, 2021
The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global Nr1d1 deletion driving dysregulation of white adipose tissue (WAT) lipogenesis and obesity.
Ann Louise Hunter, Charlotte E Pelekanou, Nichola J Barron, Rebecca C Northeast, Magdalena Grudzien, Antony D Adamson, Polly Downton, Thomas Cornfield, Peter S Cunningham, Jean-Noel Billaud, Leanne Hodson, Andrew SI Loudon, Richard D Unwin, Mudassar Iqbal, David W Ray, David A Bechtold   +15 more
doaj   +5 more sources

The Distribution, Expression Patterns and Functional Analysis of NR1D1 and NR4A2 in the Reproductive Axis Tissues of the Male Tianzhu White Yak

Animals, 2021
Nuclear hormone receptors NR1D1 and NR4A2 play important roles in the synthesis and metabolism of hormones that are thought to be strictly regulated by the hypothalamus-pituitary-gonad axis (HPG) tissues via gene expression.
Quanwei Zhang, Bohao Zhang, Zhao Xingxu   +2 more
exaly   +3 more sources

One Bout of Aerobic Exercise Can Enhance the Expression of Nr1d1 in Oxidative Skeletal Muscle Samples

Frontiers in Physiology, 2021
The nuclear receptor subfamily 1, group D member 1 (Nr1d1), plays a role in the skeletal muscle’s oxidative capacity, mitochondrial biogenesis, atrophy genes, and muscle fiber size.
Rafael Lemes Rovina, Alisson Luiz Da Rocha, JOSÉ Rodrigo Pauli   +2 more
exaly   +3 more sources

Nuclear receptor Nr1d1 links sleep deprivation to intestinal homeostasis via microbiota-derived taurine [PDF]

Journal of Translational Medicine
Background Sleep deficiency significantly compromises human health, with the gut being particularly susceptible. However, the molecular mechanisms by which gut microbiota mediate sleep deprivation-induced intestinal dysfunction remain largely undefined ...
Zhaoyang Wang, Lili Zhou, Yingkai Zheng, Xiaolan Zhong, Rufei Huang, Wei Sun, Shuai Wang, Wanglin Li   +7 more
doaj   +2 more sources

Uncovering Anticancer Mechanisms of Spiramycin Derivatives Using Transcriptomic and Metabolomic Analyses [PDF]

Metabolites
Background: Carrimycin is a mixture of spiramycin derivatives with antibacterial functions. However, recent studies have shown that it possesses certain anticancer properties. The specific mechanism of the anticancer activity is unknown.
Renyu Yang, Wuxiyar Otkur, Tingze Feng, Yirong Li, Shaojun Pei, Huan Qi, Yaopeng Zhao, Yao Lu, Hailong Piao   +8 more
doaj   +2 more sources

Glucocorticoid receptor-mediated Nr1d1 chromatin circadian misalignment in stress-induced irritable bowel syndrome

iScience, 2023
Summary: Stress-elevated glucocorticoids cause circadian disturbances and gut-brain axis (GBA) disorders, including irritable bowel syndrome (IBS). We hypothesized that the glucocorticoid receptor (GR/NR3C1) might cause chromatin circadian misalignment ...
Gen Zheng, Suya Pang, Junbao Wang, Fangyu Wang, Qi Wang, Lili Yang, Mengdie Ji, Dejian Xie, Shengtao Zhu, Yang Chen, Yan Zhou, Gerald A. Higgins, John W. Wiley, Xiaohua Hou, Rong Lin   +14 more
doaj   +1 more source