Results 41 to 50 of about 4,156 (159)

Ancestry Matters in Decoding Immunity

Immunology &Cell Biology, Volume 104, Issue 7, Page 708-710, August 2026.
The Chinese Immune Multi‐Omics Atlas (CIMA) establishes a population‐scale immune multi‐omics atlas by profiling over 10 million peripheral blood mononuclear cells from 428 Chinese adults using paired scRNA‐seq and scATAC‐seq. This resource mitigates longstanding European ancestry bias in single‐cell genomics and enables cell type resolved regulatory ...
Kesong Wu, Amanda J. Oliver, Zewen Kelvin Tuong   +2 more
wiley   +1 more source

The expression and prognostic significance of circadian gene NR1D1/2 in patients with gastric cancer

, 2023
Abstract Objective: The dysregulation of circadian rhythms is proved to be associated with the development of and may affect the treatment of tumors. However, the biological role of NR1D1/2 remains elusive in gastric cancer. We analyzed the effects of NR1D1/2 expression with occurrence and prognostic value for gastric cancer. Methods: By using
Zhixue Zheng, Xuan Cai, Jing Tao Bi, Ya Qi Liu   +3 more
openaire   +1 more source

Comprehensive analysis of lncRNA-mRNAs co-expression network identifies potential lncRNA biomarkers in cutaneous squamous cell carcinoma

BMC Genomics, 2022
Background Cutaneous squamous cell carcinoma (cSCC) is the second most common type of skin cancer, the prognosis for patients with metastatic cSCC remains relatively poor.
Yu Hu, Rong Li, Hongyin Chen, Lihao Chen, Xuyue Zhou, Linxi Liu, Mei Ju, Kun Chen, Dan Huang   +8 more
doaj   +1 more source

Food and Medicinal Homologous Substances in Sleep Disorders Improvement: Current Advances and Future Perspectives

Food Frontiers, Volume 7, Issue 4, July 2026.
The schematic diagram illustrating the improvement mechanisms of six typical FMH substances and their main active ingredients in different sleep disorders. ABSTRACT Sleep integrates many brain and peripheral processes, profoundly influencing well‐being.
Wenjing Wen, Qili Li, Chenghao Lv, Jing Wen, Yihan Zhang, Yuhang Yi, Tao Li, Fang Wang, Yibo Luo, Si Qin   +9 more
wiley   +1 more source

Rev-erbα heterozygosity produces a dose-dependent phenotypic advantage in mice.

PLoS ONE, 2020
Numerous mutational studies have demonstrated that circadian clock proteins regulate behavior and metabolism. Nr1d1(Rev-erbα) is a key regulator of circadian gene expression and a pleiotropic regulator of skeletal muscle homeostasis and lipid metabolism.
Ryan D Welch, Cyrielle Billon, Amina Kameric, Thomas P Burris, Colin A Flaveny   +4 more
doaj   +1 more source

Arenobufagin causes ferroptosis in human gastric cancer cells by increasing rev-erbα expression

Journal of Traditional and Complementary Medicine, 2023
Background and aims: Gastric cancer is the fifth most diagnosed malignant tumor worldwide with limited effective chemotherapy. Ferroptosis is a new type of programmed cell death, which is becoming as a novel therapeutic target for tumors.
Ke Chen, Angling Li, Jian Wang, Dongchang Li, Xiaoshan Wang, Chengwei Liu, Zhengguang Wang   +6 more
doaj   +1 more source

Biphenotypic Sinonasal Sarcoma With a Novel PAX3::MAML2 Fusion

Genes, Chromosomes and Cancer, Volume 65, Issue 7, July 2026.
ABSTRACT Biphenotypic sinonasal sarcoma (BSNS) is a rare, low‐grade spindle cell sarcoma of the sinonasal tract. It is characterized by dual neural and myogenic differentiation and classically shows fusions involving PAX3. MAML3, a co‐activator in the Notch signaling pathway, is the most common fusion partner of PAX3.
Mayu Uemura, Anna Fong Na Goh, Amit Kumar, Gary Quagliotto, Pranav Dorwal   +4 more
wiley   +1 more source

NR1D1 Inhibition Enhances Autophagy and Mitophagy in Alzheimer's Disease Models

aging and disease
Alzheimer's disease (AD) is marked by extracellular beta-amyloid (Aβ) plaques and intracellular Tau tangles, leading to progressive cognitive decline and neuronal dysfunction. Impaired autophagy, a process by which a cell breaks down and destroys damaged or abnormal proteins and other substances, contributes to AD progression.
Shi-Qi, Zhang, Zhangming, Niu, Alexander, Anisimov, Fang, Shi, Shenglong, Deng, Xianglu, Xiao, Shu-Qin, Cao, Jun-Ping, Pan, He-Ling, Wang, Maria J, Lagartos-Donate, Nihal Gullu, Bozbas, Ping-Jie, Wang, Ruixue, Ai, Yan, Li, Guang, Yang, Sofie, Lautrup, Evandro F, Fang   +16 more
openaire   +2 more sources

The circadian gene Nr1d1 in the mouse nucleus accumbens modulates sociability and anxiety‐related behaviour [PDF]

European Journal of Neuroscience, 2018
AbstractNuclear receptor subfamily 1, group D, member 1 (Nr1d1) (also known as Rev‐erb alpha) has been linked to circadian rhythm regulation, mood‐related behaviour and disorders associated with social deficits. Recent work from our laboratory found striking decreases in Nr1d1 in the nucleus accumbens (NAc) in the maternal condition and indirect ...
Changjiu Zhao, Stephen C. Gammie
openaire   +3 more sources

SR9009 attenuates inflammation-related NPMSC pyroptosis and IVDD through NR1D1/NLRP3/IL-1β pathway

iScience
Summary: Intervertebral disc is a highly rhythmical tissue. As a key factor linking biorhythm and inflammatory response, the shielding effect of NR1D1 in the process of intervertebral disc degeneration remains unclear. Here, we first confirmed that NR1D1
Ze-Nan Huang, Jing Wang, Ze-yu Wang, Ling-yuan Min, Hai-Ling Ni, Yan-Ling Han, You-yue Tian, Ya-Zhou Cui, Jing-Xiang Han, Xiao-Fei Cheng   +9 more
doaj   +1 more source