Results 51 to 60 of about 4,156 (159)

Single-cell in vivo imaging of cellular circadian oscillators in zebrafish.

PLoS Biology, 2020
The circadian clock is a cell-autonomous time-keeping mechanism established gradually during embryonic development. Here, we generated a transgenic zebrafish line carrying a destabilized fluorescent protein driven by the promoter of a core clock gene ...
Haifang Wang, Zeyong Yang, Xingxing Li, Dengfeng Huang, Shuguang Yu, Jie He, Yuanhai Li, Jun Yan   +7 more
doaj   +1 more source

Ossifying spindled and epithelioid tumour: Expanding the clinical and morphologic spectrum of a recently described entity

Histopathology, Volume 89, Issue 1, Page 163-173, July 2026.
Ossifying spindled and epithelioid tumour (OSET) can show unusual morphologic features, including minimal or absent peripheral ossification, eosinophil‐rich stroma, increased mitotic activity (≥5 mitotic figures per 10 high‐power fields), and necrosis.
Rayan M Sibira, Benjamin F Smith, Amy Davis, Jessica L Davis, Nada Mohamed, Riyam Zreik, David J Papke Jr., Michael Michal, Sintawat Wangsiricharoen, Karen J Fritchie   +9 more
wiley   +1 more source

Proanthocyanidin‐Rich Cranberry Extract Lowers Glycemia in Established Obesity by Delaying Glucose Absorption

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Schematic summary of the metabolic effects and proposed mechanisms of action of proanthocyanidin‐rich cranberry extract (PRCE) supplementation in mice with established diet‐induced obesity housed under thermoneutral (30°C) or cold‐exposed (10°C) conditions.
Sarra Beji, Mathilde Mouchiroud, Laura Tribouillard, Bernie Efole, Lia Perazza, Léa Favereaux, Audrey Poirier, Wandy Idris, Yves Gélinas, Thibault V. Varin, Carole Rovère, Fernando Forato Anhê, Frédéric Picard, Mathieu Laplante, André Marette, Andréanne Michaud, Alexandre Caron   +16 more
wiley   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, Volume 13, Issue 33, 15 June 2026.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Clock gene NR1D1 mediated inflammatory response after Streptococcus agalactiae challenge in Nile Tilapia (Oreochromis niloticus) brain

Aquaculture Reports
Neuronal injury caused by Streptococcus agalactiae (S. agalactiae) poses a threat to the survival of tilapia. However, the molecular regulatory mechanisms underlying this process remain largely unknown. In this study, a comparative transcriptome analysis
Zhang Wang, Zhigang Liu, Weijuan Zhu, Meiyan Zhang, Shaowei Huang, Jianmeng Cao, Miao Wang, Mengmeng Yi, Fengying Gao, Maixin Lu, Xiaoli Ke   +10 more
doaj   +1 more source

Porphyromonas gingivalis disrupts hippocampal circadian clock via PI3K/AKT pathway, exacerbating Alzheimer‐like pathology

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
A graphical abstract is provided to visually summarize the key findings of this study. Abstract INTRODUCTION Periodontal pathogen Porphyromonas gingivalis is epidemiologically linked to Alzheimer's disease (AD), yet how oral infection disrupts the central circadian clock to drive hippocampal neurodegeneration remains unknown.
Chunmei Huang, Qin Cai, Zeru Feng, Chenze Zhang, Zhiqiang Luo, Xingqun Cheng, Hongkun Wu   +6 more
wiley   +1 more source

Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock.

PLoS ONE, 2019
Genome-wide association study (GWAS) loci for several immunity-mediated diseases (early onset asthma, inflammatory bowel disease (IBD), primary biliary cholangitis, and rheumatoid arthritis) map to chromosomal region 17q12-q21.
Matthew L Chang, Sanny Moussette, Enrique Gamero-Estevez, José Héctor Gálvez, Victoria Chiwara, Indra R Gupta, Aimee K Ryan, Anna K Naumova   +7 more
doaj   +1 more source

Exercise Intervention for REM Sleep Behavior Disorder in Parkinson's Disease: Mechanisms and Implications for Neurorehabilitation

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This review systematically explores exercise as a multi‐target intervention for RBD, highlighting its mechanisms of action and regulatory effects on key pathophysiological processes. ABSTRACT Backgrounds REM sleep behavior disorder (RBD) is a prodromal non‐motor symptom of Parkinson's disease (PD) and other α‐synucleinopathies, affecting approximately ...
Xinhui Qiu, Zihui Wang, Ruixue Xu, Yiying Hu, Weidong Le   +4 more
wiley   +1 more source

Solanesol Alleviates Perfluoroheptanoic Acid‐Induced Premature Senescence in Human Skin Fibroblasts via RNA Methylation

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Perfluoroheptanoic acid (PFHpA) induces premature senescence in normal human skin fibroblasts (HSFs), as characterized by decreased cell viability, increased SA‐β‐gal staining, impaired wound healing, cell cycle dysregulation, elevated ROS levels, and upregulated SASP mRNA expression.
Jiaqi Fu, Tingting Huang, Guisong Li, Xinyu Zhang, Luyi Tan, Chenyu Zhu, Wenji Zhang, Wenjuan Zhang   +7 more
wiley   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1987-2002, June 2026.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source