Results 1 to 10 of about 4,155 (132)

Circadian clock molecule REV-ERBα regulates lung fibrotic progression through collagen stabilization [PDF]

Nature Communications, 2023
The molecular clock REV-ERBα regulates lung injury during fibrosis, but the role of REV-ERBα in fibrogenesis remains unknown. Here, the authors show that REV-ERBα interacts with the lysyl oxidase-collagen axis during fibrogenesis and demonstrate the ...
Qixin Wang, Isaac Kirubakaran Sundar, Joseph H. Lucas, Jun-Gyu Park, Aitor Nogales, Luis Martinez-Sobrido, Irfan Rahman   +6 more
doaj   +2 more sources

Targeting REV-ERBα/BNIP3 axis attenuates pulmonary arterial hypertension by repressing mitophagy in mice [PDF]

Nature Communications
Pulmonary arterial hypertension (PAH) is a life-threatening metabolic disorder. Nuclear receptors REV-ERBα and REV-ERBβ are established regulators of circadian rhythm and metabolic homeostasis, however their roles in PAH remain unclear. Using Rev-erbα +/-
Lejia Qiu, Tingting Lu, Jiayang Zhang, Min Liu, Hui Wang, Wenyu Li, Changxiao Ma, Shuyao Li, Baoyin Ren, Qiong Wang, Fenling Fan, Hu Xu, Feng Zheng, Youfei Guan, Xiaoyan Zhang, Guangrui Yang, Lihong Chen   +16 more
doaj   +2 more sources

Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice [PDF]

Nature Communications, 2023
Alzheimer’s disease, the most common age-related neurodegenerative disease, is characterized by tau aggregation and associated with disrupted circadian rhythms and dampened clock gene expression.
Jiyeon Lee, Julie M. Dimitry, Jong Hee Song, Minsoo Son, Patrick W. Sheehan, Melvin W. King, G. Travis Tabor, Young Ah Goo, Mitchell A. Lazar, Leonard Petrucelli, Erik S. Musiek   +10 more
doaj   +2 more sources

Ovarian Rev-erbα: a central regulator of fertility following chronodisruption [PDF]

Frontiers in Endocrinology
IntroductionCircadian rhythm disruption caused by shift work, nutritional imbalance, and the stresses of modern life can alter hormone secretion, lead to menstrual irregularities, impair follicle development, and contribute to ovarian hypoplasia.
Shalini Gupta, Saumyata Kumawat, Saumyata Kumawat, Vipashu Kaushal, Vipashu Kaushal, Rashmi Arora, Rashmi Arora, Sumit Kumar, Rahul Sharma, Rahul Sharma, Anshu Bhardwaj, Anshu Bhardwaj, Neeraj Khatri, Neeraj Khatri, Pawan Gupta, Pawan Gupta   +15 more
doaj   +2 more sources

Impact of the circadian nuclear receptor REV-ERBα in dorsal raphe 5-HT neurons on social interaction behavior, especially social preference [PDF]

Experimental and Molecular Medicine, 2023
Social interaction among conspecifics is essential for maintaining adaptive, cooperative, and social behaviors, along with survival among mammals. The 5-hydroxytryptamine (5-HT) neuronal system is an important neurotransmitter system for regulating ...
Sangwon Jang, Inah Park, Mijung Choi, Jihoon Kim, Seungeun Yeo, Sung-Oh Huh, Ji-Woong Choi, Cheil Moon, Han Kyoung Choe, Youngshik Choe, Kyungjin Kim   +10 more
doaj   +2 more sources

Targeting Circadian Protein Rev-erbα to Alleviate Inflammation, Oxidative Stress, and Enhance Functional Recovery Following Brain Trauma [PDF]

Antioxidants
Traumatic brain injury (TBI) is a significant cause of morbidity and mortality worldwide, and its pathophysiology is characterized by oxidative stress and inflammation. Despite extensive research, effective treatments for TBI remain elusive.
Arief Gunawan Darmanto, Jing-Shiun Jan, Ting-Lin Yen, Shin-Wei Huang, Ruei-Dun Teng, Jia-Yi Wang, Rajeev Taliyan, Joen-Rong Sheu, Chih-Hao Yang   +8 more
doaj   +2 more sources

Rev-erbα agonist SR9009 protects against cerebral ischemic injury through mechanisms involving Nrf2 pathway [PDF]

Frontiers in Pharmacology, 2023
Backgrounds: The circadian clock protein Rev-erbα is a crucial regulator of circadian rhythms that affects multiple molecular, cellular, and physiology pathways that control susceptibility, injury, and recovery in the neurological disorders.
Mingyue Sheng, Mingyue Sheng, Xun Chen, Xun Chen, Yan Yu, Yan Yu, Qi Wu, Junping Kou, Junping Kou, Gangling Chen, Gangling Chen   +10 more
doaj   +2 more sources

Targeting Rev-Erbα to protect against ischemia-reperfusion-induced acute lung injury in rats [PDF]

Respiratory Research, 2023
Background The dysregulation of local circadian clock has been implicated in the pathogenesis of a broad spectrum of diseases. However, the pathophysiological role of intrinsic circadian clocks Rev-Erbα in ischemia-reperfusion (IR)-induced acute lung ...
Shi-Jye Chu, Wen-I Liao, Hsin-Ping Pao, Shu-Yu Wu, Shih-En Tang   +4 more
doaj   +2 more sources

The nuclear receptor REV-ERBα is implicated in the alteration of β-cell autophagy and survival under diabetogenic conditions [PDF]

Cell Death and Disease, 2022
Pancreatic β-cell failure in type 2 diabetes mellitus (T2DM) is associated with impaired regulation of autophagy which controls β-cell development, function, and survival through clearance of misfolded proteins and damaged organelles.
Matthew R. Brown, Damien Laouteouet, Morgane Delobel, Orianne Villard, Christophe Broca, Gyslaine Bertrand, Anne Wojtusciszyn, Stéphane Dalle, Magalie A. Ravier, Aleksey V. Matveyenko, Safia Costes   +10 more
doaj   +2 more sources

REV-ERBα inhibitor rescues MPTP/MPP+-induced ferroptosis of dopaminergic neuron through regulating FASN/SCD1 signaling pathway [PDF]

Heliyon
Circadian disruption is a risk factor for Parkinson's disease (PD). Ferroptosis, a cellular death process, assumes a pivotal role in the degeneration of dopaminergic neurons in PD.
Xiaoyu Wang, Mingmei Wang, Hui Zhi, Jingwei Li, Dongkai Guo   +4 more
doaj   +2 more sources