Sex-dependent relationship of polymorphisms in CLOCK and REV-ERBα genes with body mass index and lipid levels in children [PDF]
Scientific Reports, 2023 Circadian rhythms, which are governed by a circadian clock, regulate important biological processes associated with obesity. SNPs in circadian clock genes have been linked to energy and lipid homeostasis.
Claudia Vales-Villamarín +7 more
doaj +2 more sources
Light Exposure, Physical Activity, and Indigeneity Modulate Seasonal Variation in NR1D1 (REV-ERBα) Expression [PDF]
BiologyNuclear receptor subfamily 1 group D member 1 (NR1D1 or REV-ERBα) is a crucial element of the circadian clock’s transcriptional and translational feedback loop.
Denis Gubin +13 more
doaj +2 more sources
Dysfunctional decidual CD2+CD4+T cells regulated by Rev-erbα - GFPT1 - GPI anchored CD58 axis of decidual stromal cells underlies sleep disturbance induced recurrent pregnancy loss [PDF]
Frontiers in ImmunologyBackgroundThe multifactorial nature of recurrent pregnancy loss (RPL) requires a comprehensive understanding of its diverse risk factors, including sleep disturbance.
Mingke Qiu +10 more
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Role of the circadian nuclear receptor REV-ERBα in dorsal raphe serotonin synthesis in mood regulation [PDF]
Communications BiologyAffective disorders are frequently associated with disrupted circadian rhythms. The existence of rhythmic secretion of central serotonin (5-hydroxytryptamine, 5-HT) pattern has been reported; however, the functional mechanism underlying the circadian ...
Inah Park +13 more
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Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome
Molecular Metabolism, 2017 Objective: The loss of skeletal muscle mass and strength are a central feature of traumatic injury and degenerative myopathies. Unfortunately, pharmacological interventions typically fail to stem the long-term decline in quality of life.
Marvin Meyers +2 more
exaly +3 more sources
Olfactory Ensheathing Cell Ameliorate Neuroinflammation Following Spinal Cord Injury Through Upregulating REV-ERBα in Microglia [PDF]
Cell TransplantationCircadian dysregulation involved in the pathophysiology of spinal cord injury (SCI). Modulation of circadian rhythms hold promise for the SCI treatment.
Lijian Zhang +4 more
doaj +2 more sources
Deficiency of circadian clock gene Bmal1 exacerbates noncanonical inflammasome-mediated pyroptosis and lethality via Rev-erbα-C/EBPβ-SAA1 axis [PDF]
Experimental and Molecular MedicineCircadian arrhythmia has been linked to increased susceptibility to multiple inflammatory diseases, such as sepsis. However, it remains unclear how disruption of the circadian clock modulates molecular aspects of innate immune responses, including ...
Do-Wan Shim +7 more
doaj +2 more sources
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Rev-erbα represents a powerful transcriptional repressor involved in immunity. However, the regulation, function, and clinical relevance of Rev-erbα in Helicobacter pylori infection are presently unknown.
Fang-Yuan Mao +12 more
doaj +1 more source
Scientific Reports, 2021 The transcriptional repressor Rev-erbα is known to down-regulate fatty acid metabolism and gluconeogenesis gene expression. In animal models, disruption of Rev-erbα results in global changes in exercise performance, oxidative capacity, and blood glucose ...
Sean P. Gillis +5 more
doaj +1 more source
The transcriptional repressor Rev-erbα regulates circadian expression of the astrocyte Fabp7 mRNA
Current Research in Neurobiology, 2021 The astrocyte brain-type fatty-acid binding protein (Fabp7) circadian gene expression is synchronized in the same temporal phase throughout mammalian brain.
William M. Vanderheyden +4 more
doaj +1 more source