Results 21 to 30 of about 4,155 (132)
Rev-erbα exacerbates hepatic steatosis in alcoholic liver diseases through regulating autophagy
Cell & Bioscience, 2021 Background and aims Alcoholic fatty liver (AFL) is a liver disease caused by long-term excessive drinking and is characterized by hepatic steatosis. Understanding the regulatory mechanism of steatosis is essential for the treatment of AFL.
Qingxue Liu +8 more
doaj +1 more source
The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis. [PDF]
PLoS ONE, 2014 The function of the nuclear receptor Rev-erbα (Nr1d1) in the brain is, apart from its role in the circadian clock mechanism, unknown. Therefore, we compared gene expression profiles in the brain between wild-type and Rev-erbα knock-out (KO) animals.
Anna Schnell +9 more
doaj +1 more source
Redox Biology, 2022 Retinal pigment epithelium (RPE) dysfunction and atrophy occur in dry age-related macular degeneration (AMD), often leading to photoreceptor degeneration and vision loss.
Shuo Huang +9 more
doaj +1 more source
Direct regulation of CLOCK expression by REV-ERB. [PDF]
PLoS ONE, 2011 Circadian rhythms are regulated at the cellular level by transcriptional feedback loops leading to oscillations in expression of key proteins including CLOCK, BMAL1, PERIOD (PER), and CRYPTOCHROME (CRY).
Christine Crumbley, Thomas P Burris
doaj +1 more source
REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis
eLife, 2020 The circadian clock regulates various aspects of brain health including microglial and astrocyte activation. Here, we report that deletion of the master clock protein BMAL1 in mice robustly increases expression of complement genes, including C4b and C3 ...
Percy Griffin +7 more
doaj +1 more source
Cell Death and Disease, 2021 The circadian clock is closely related to the development of diabetes mellitus and cardiovascular disease, and disruption of the circadian clock exacerbates myocardial ischaemia/reperfusion injury (MI/RI).
Zhen Qiu +7 more
doaj +1 more source
The effects of the heme precursor 5-aminolevulinic acid (ALA) on REV-ERBα activation
FEBS Open Bio, 2014 The nuclear receptor, REV-ERBα, has a key role in circadian rhythms and requires heme as its ligand. The present study determined whether the heme precursor, 5-aminolevulinic acid (ALA), affects REV-ERBα and its target genes.
Kohei Yamashita +5 more
doaj +1 more source
Technology in Cancer Research & Treatment, 2021 Retinoid-related orphan receptor alpha (RORα) and nuclear receptor subfamily 1 group D member 1 (REV-ERBα) play critical roles in many human cancers.
Xiaoshan Wang MM +5 more
doaj +1 more source
Oncotarget, 2018 // Dapeng Yu 1,2,* , Yong Li 2,* , Yu Zhou 3,4,* , Masanobu Abe 5 , Liang Zong 4,6 and Ju Gao 1,2 1 Graduate School of Medicine, The Second Xiangya Hospital of Central South University, Changsha, China 2 Department of Anesthesiology, Clinical Medical School of Yangzhou University (Subei People’s Hospital of Jiangsu Province), Yangzhou ...
Dapeng Yu +11 more
openaire +1 more source
JCI Insight, 2021 Cigarette smoke (CS) is the main etiological factor in the pathogenesis of emphysema/chronic obstructive pulmonary disease (COPD), which is associated with abnormal epithelial-mesenchymal transition (EMT).
Qixin Wang +4 more
doaj +1 more source