Results 31 to 40 of about 4,155 (132)

Circadian gene Rev-erbα influenced by sleep conduces to pregnancy by promoting endometrial decidualization via IL-6-PR-C/EBPβ axis

Journal of Biomedical Science, 2022
Background Sleep disturbance can cause adverse pregnancy outcomes by changing circadian gene expression. The potential mechanisms remain unclear.
Liyuan Cui, Feng Xu, Chunfang Xu, Yan Ding, Songcun Wang, Meirong Du   +5 more
doaj   +1 more source

Dietary Conjugated Linoleic Acid Modulates the Hepatic Circadian Clock Program via PPARα/REV-ERBα-Mediated Chromatin Modification in Mice

Frontiers in Nutrition, 2021
Scope: Disruptions of circadian rhythm cause metabolic disorders and are closely related to dietary factors. In this study, we investigated the interplays between the dietary conjugated linoleic acid (CLA)-induced hepatic steatosis and the circadian ...
Hao-Yu Liu, Haotian Gu, Yanwei Li, Ping Hu, Yatian Yang, Kaiqi Li, Hao Li, Kexin Zhang, Bo Zhou, Huaxing Wu, Wenbin Bao, Demin Cai   +11 more
doaj   +1 more source

Direct and Indirect Suppression of Interleukin-6 Gene Expression in Murine Macrophages by Nuclear Orphan Receptor REV-ERBα

The Scientific World Journal, 2014
It is now evident that many nuclear hormone receptors can modulate target gene expression. REV-ERBα, one of the nuclear hormone receptors with the capacity to alter clock function, is critically involved in lipid metabolism, adipogenesis, and the ...
Shogo Sato, Takuya Sakurai, Junetsu Ogasawara, Ken Shirato, Yoshinaga Ishibashi, Shuji Oh-ishi, Kazuhiko Imaizumi, Shukoh Haga, Yoshiaki Hitomi, Tetsuya Izawa, Yoshinobu Ohira, Hideki Ohno, Takako Kizaki   +12 more
doaj   +1 more source

The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson’s disease via the microglial NLRP3 inflammasome

Journal of Neuroinflammation, 2022
Background Circadian disturbance is a common nonmotor complaint in Parkinson’s disease (PD). The molecular basis underlying circadian rhythm in PD is poorly understood. Neuroinflammation has been identified as a key contributor to PD pathology.
Liang Kou, Xiaosa Chi, Yadi Sun, Chao Han, Fang Wan, Junjie Hu, Sijia Yin, Jiawei Wu, Yunna Li, Qiulu Zhou, Wenkai Zou, Nian Xiong, Jinsha Huang, Yun Xia, Tao Wang   +14 more
doaj   +1 more source

Circadian Clock Genes REV-ERBs Inhibits Granulosa Cells Apoptosis by Regulating Mitochondrial Biogenesis and Autophagy in Polycystic Ovary Syndrome

Frontiers in Cell and Developmental Biology, 2021
Polycystic ovary syndrome (PCOS) is an endocrinopathy with complex pathophysiology that is a common cause of anovulatory infertility in women. Although the disruption of circadian rhythms is indicated in PCOS, the role of the clock in the etiology of ...
Lihua Sun, Hui Tian, Songguo Xue, Hongjuan Ye, Xue Xue, Rongxiang Wang, Yu Liu, Caixia Zhang, Qiuju Chen, Shaorong Gao   +9 more
doaj   +1 more source

Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model

Journal of Neuroinflammation, 2020
Background A hallmark of temporal lobe epilepsy (TLE) is brain inflammation accompanied by neuronal demise. Accumulating evidence demonstrates that Rev-Erbα is involved in regulating neuroinflammation and determining the fate of neurons.
Jiong Yue, Jiaojiang He, Yujia Wei, Kaifeng Shen, Kefu Wu, Xiaolin Yang, Shiyong Liu, Chunqing Zhang, Hui Yang   +8 more
doaj   +1 more source

Chronoeffects of the Herbal Medicines Puerariae radix and Coptidis rhizoma in Mice: A Potential Role of REV-ERBα

Frontiers in Pharmacology, 2021
Identifying drugs with dosing time-dependent effects (chronoeffects) and understanding the underlying mechanisms would help to improve drug treatment outcome.
Jinming Liu, Haiman Xu, Haiman Xu, Li Zhang, Li Zhang, Shuai Wang, Shuai Wang, Danyi Lu, Danyi Lu, Min Chen, Min Chen, Baojian Wu   +11 more
doaj   +1 more source

Angiotensin II Suppresses Rev-erbα Expression in THP-1 Macrophages via the Ang II Type 1 Receptor/Liver X Receptor α Pathway

Cellular Physiology and Biochemistry, 2018
Background/Aims: Angiotensin II (Ang II) regulates the expression of some core clock genes; excess Ang II leads to atherosclerosis advancement.
Shipeng Wang, Xia Gu, Qi Zhang, Xiling Zhang, Yilan Li, Yuan Yao, Bo Yu, Yao Zhang   +7 more
doaj   +1 more source

Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models

Nature Communications, 2021
Rev-erbα is a known regulator of the circadian clock. Here, the authors show that Rev-erbα is also a regulator of synaptic dysfunction in preclinical models of epilepsy.
Tianpeng Zhang, Fangjun Yu, Haiman Xu, Min Chen, Xun Chen, Lianxia Guo, Cui Zhou, Yuting Xu, Fei Wang, Jiandong Yu, Baojian Wu   +10 more
doaj   +1 more source

Rev-erbα heterozygosity produces a dose-dependent phenotypic advantage in mice.

PLoS ONE, 2020
Numerous mutational studies have demonstrated that circadian clock proteins regulate behavior and metabolism. Nr1d1(Rev-erbα) is a key regulator of circadian gene expression and a pleiotropic regulator of skeletal muscle homeostasis and lipid metabolism.
Ryan D Welch, Cyrielle Billon, Amina Kameric, Thomas P Burris, Colin A Flaveny   +4 more
doaj   +1 more source