Results 51 to 60 of about 4,155 (132)

Origin of Physicochemical and Mechanical Stability of Low‐Temperature Prepared TiO2‐Based Photocatalytic Films: Surface Hydroxyl Density Matching

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Material science advances show how surface chemistry improves low‐temperature prepared TiO2‐SiO2 composite films. Using a colloidal‐based synthesis method instead of a powdered‐based one, researchers exploit hydroxyl groups' interfacial interactions to create nanoscale structures with superior physicochemical and mechanical stability.
Andraž Šuligoj, Mohamad El‐Roz, Goran Dražić, Frédéric Thibault‐Starzyk, Pegie Cool, Nataša Zabukovec Logar, Urška Lavrenčič Štangar, Nataša Novak Tušar   +7 more
wiley   +1 more source

Pharmacological activation of rev-erbα suppresses LPS-induced macrophage M1 polarization and prevents pregnancy loss

BMC Immunology, 2021
Background Circadian rhythm is an important player for reproduction. Rev-erbα, a significant clock gene, is involved in regulating cell differentiation, inflammation and metabolism.
Liyuan Cui, Feng Xu, Songcun Wang, Xinyi Li, Haiyan Lin, Yan Ding, Meirong Du   +6 more
doaj   +1 more source

Reverse evolution of fluorine and side chains in bisisoindigo‐based copolymers enabling electron mobility exceeding 7 cm2·V−1·s−1

FlexMat, EarlyView.
Abstract We report the design and synthesis of a series of bisisoindigo‐based donor–acceptor (D–A) copolymers, P4F18, P4F10, P2F18, and P2F10. By reverse evolution of fluorine substitution and side‐chain structure, we effectively tuned the frontier molecular orbital energy levels, intermolecular interactions, molecular self‐assembly, and thus charge ...
Keli Shi, Chang Cui, Qianqian Zhao, Jianping Chen, Weifeng Zhang, Jiadi Chen, Qian Che, Yunchao Zhang, Youjia Li, Zhihui Chen, Liping Wang, Gui Yu   +11 more
wiley   +1 more source

Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway

Cardiovascular Therapeutics, 2023
Background. Doxorubicin-induced cardiotoxicity has been closely concerned in clinical practice. Rev-erbα is a transcriptional repressor that emerges as a drug target for heart diseases recently. This study is aimed at investigating the role and mechanism
Runmei Zou, Shuo Wang, Hong Cai, Yuwen Wang, Cheng Wang   +4 more
doaj   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

SR9009 Regulates Acute Lung Injury in Mice Induced by Sepsis

Canadian Respiratory Journal, 2022
Rev-Erbα is a nuclear heme receptor, transcriptional repressor, and critical component of the molecular clock that drives daily rhythms of metabolism. However, the roles of Rev-Erbα in acute lung injury (ALI) remain unclarified.
Ming Hu, Li Zhang, Jie Cao, Yu Jiang, Gang Liu   +4 more
doaj   +1 more source

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

The Journal of Pathology, EarlyView.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli   +8 more
wiley   +1 more source

Influence of crosslinker on the properties of terpene‐based poly(high internal phase emulsion)s

Polymer International, EarlyView.
Myrcene was polymerized and crosslinked with hydrophilic monomeric and oligomeric dimethacrylates within high internal phase emulsions to produce hierarchically porous bio‐based poly(high internal phase emulsion)s with tuned morphology and mechanical properties.
Rumeysa Beyaz, Stanko Kramer, Burcu Kekevi, E. Hilal Mert, Irena Pulko, Peter Krajnc   +5 more
wiley   +1 more source

Dynamic Polydisulfide Latex via Emulsion Ring‐Opening Polymerization of Cyclodisulfides

Journal of Polymer Science, EarlyView.
A polydisulfide latex with a high molar mass was achieved by emulsion polymerization process starting from a dithiol. The mechanism reveals an entropy‐driven ring‐opening polymerization involving disulfide macrocycle intermediates. The polydisulfide particles can be degraded by thiol‐disulfide exchange, and the disulfide fragments can be reengaged in a
Sandric Afonso, Pierre‐Louis Quentin, Marc Schmutz, Cécile Joyeux, Cuong Minh Quoc Le, Abraham Chemtob   +5 more
wiley   +1 more source