Results 71 to 80 of about 4,155 (132)

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong, Zhen Wang, Xiaoxiao Lin, Ziwen Lei, Qianqian Huang, Hang Liu, Fei Luan, Junbo Zou, Yajun Shi   +8 more
wiley   +1 more source

Macrophage: Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Macrophages are sentinel innate immune cells that arise from embryonic precursors and bone marrow monocytes, displaying a functional continuum that transcends the classical M1 (pro‐inflammatory)/M2 (anti‐inflammatory) dichotomy. Under homeostatic conditions, balanced M1/M2 polarization preserves tissue integrity by coordinating immune surveillance ...
Bihang Sun, Linqing Wen, Shiyun Tang, Lu Liu, Nianzhi Chen   +4 more
wiley   +1 more source

Effects of Probiotic Supplementation on Circadian Rhythm‐Related Gene Expression and Body Weight in Mice With Disturbed Circadian Rhythms

Molecular Nutrition &Food Research, Volume 70, Issue 15, 17 August 2026.
Male BALB/c mice were assigned to control, circadian disruption, or circadian disruption plus probiotic groups for 16 weeks. Body weight and circadian clock gene expression (Clock, Bmal1, and Per2) were evaluated. Probiotic supplementation partially modulated weight gain and influenced circadian gene regulation, supporting its potential as an adjunct ...
Büşra Tepebaşı, Mehtap Ünlü Söğüt, Menşure Nur Çelik, Sevtap Kabalı   +3 more
wiley   +1 more source

Chronotherapy in Hematological Malignancies: Evaluating the Rationale and Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Hematological malignancies remain one of the leading causes of morbidity and mortality despite advances in targeted therapies, immunotherapy, and stem cell transplantation. Emerging evidence indicates that treatment efficacy and toxicity depend not only on the choice of therapy but also on its timing relative to the patient's internal ...
Andrej Belančić, Marko Skelin, Yun Wah Lam, Almir Fajkić, Bruna Perkov‐Stipičin, Rossana Roncato, Ivan Krečak, Marko Lucijanić   +7 more
wiley   +1 more source

Regulating Ligand‐to‐Metal Charge Transfer in UiO‐66(Zr)‐NH2 With Site‐Isolated Cu+ Centers for Efficient Photocatalytic H2O2 Generation

Small Science, Volume 6, Issue 8, August 2026.
Incorporation of highly dispersed Cu species into UiO‐66(Zr)‐NH2 introduces a competing ligand‐to‐Cu charge–transfer pathway that suppresses charge recombination and enhances photocatalytic H2O2 production. Combined PL, TRPL, TRIR, and variable‐temperature FTIR analyses reveal Cu‐mediated modulation of excited‐state dynamics and oxygen reduction ...
Aneek Kuila, Khaled Dassouki, Aditya Swarup Lal, Ambili Ramanthrikkovil Variyam, Nirmalendu Sekhar Mishra, Eddy Dumas, Nadav Amdursky, Nathalie Steunou, Yaron Paz   +8 more
wiley   +1 more source

REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis

Nature Communications, 2018
REV-ERBα is a nuclear receptor that links the circadian pathways with those of metabolism. Here the authors show REV-ERBα is also involved with linking the circadian system with the inflammatory pathways of an experimental model of colitis through ...
Shuai Wang, Yanke Lin, Xue Yuan, Feng Li, Lianxia Guo, Baojian Wu   +5 more
doaj   +1 more source

Expression Landscape and Circadian Regulation of lncRNAs in the Kidney

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Recent multi‐omics work shows that the diurnal rhythmicity of kidney function is associated with circadian oscillations in renal mRNA, protein and metabolite abundances. Yet circadian regulation of renal lncRNAs, which are emerging as important modulators of diverse (patho)physiological processes, remains largely unexplored. Here, we provide a
Leonore Wigger, Fanny Durussel, Muriel Auberson, Dmitri Firsov, Yohan Bignon   +4 more
wiley   +1 more source

Fecal Steroids as Tracers of Human Population and Waste Management Practices at the Ancient Maya City of Ucanal, Guatemala

Archaeometry, Volume 68, Issue 4, Page 646-658, August 2026.
ABSTRACT Geochemical data compiled from dried sediments from three water reservoirs at the ancient Maya city of Ucanal, Petén, Guatemala, reveal low to undetectable fecal biomarker concentrations. These low concentrations may be the result of the aerobic decay of sterols combined with well‐managed waste disposal practices.
Jean D. Tremblay, Peter M. J. Douglas, Christina T. Halperin, Yves Gélinas   +3 more
wiley   +1 more source

Hydroxyapatite–Mesoporous Silica Composites for Dual Quercetin Release and Encapsulation Efficiency

International Journal of Applied Ceramic Technology, Volume 23, Issue 4, August 2026.
This study demonstrates that HAP/Si hybrid composites are promising carriers for quercetin delivery, offering high drug encapsulation and tunable pH‐dependent release behavior. Structural characterization confirmed successful composite formation, while release modeling indicated that diffusion and matrix erosion jointly controlled quercetin release ...
Elçin Sarıaslan, Zeynep Aktaş‐Erden, Emir Zafer Hoşgün, Berrin Bozan   +3 more
wiley   +1 more source

Cardiomyocyte-specific disruption of the circadian BMAL1-REV-ERBα/β regulatory network impacts distinct miRNA species in the murine heart. [PDF]

Commun Biol, 2023
Latimer MN, Williams LJ, Shanmugan G, Carpenter BJ, Lazar MA, Dierickx P, Young ME.   +6 more
europepmc   +1 more source