Results 61 to 70 of about 4,156 (159)

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, Volume 2, Issue 2, Page 236-279, June 2026.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Circadian Phase Modulates Embryonic Susceptibility to Bisphenol A-Induced ASD-Related Behavioral Alterations via nr1d1

Toxics
Emerging evidence links environmental exposures and circadian dysregulation to autism spectrum disorder (ASD), yet whether circadian phase modulates vulnerability to developmental toxicants remains unclear.
Ying Wu, Jianjun Liu, Pinyi Chen, Xinwei Wang, Yuting Wang, Xiaoyao Song, Jie Zhang   +6 more
doaj   +1 more source

Aging‐Related Muscle Bmal1 Decline Contributes to Bone Loss in Mice via Enhancing IL‐1α–Mediated Osteoclastogenesis

Aging Cell, Volume 25, Issue 6, June 2026.
Aging‐related decline of muscle Bmal1 drives bone loss in mice by disrupting Hmox1 and increasing IL‐1α, which promotes osteoclast activity. Time‐restricted feeding reestablishes diurnal Hmox1 expression, reduces IL‐1α, and alleviates osteoporosis, offering a potential therapeutic strategy. ABSTRACT Osteoporosis, a common metabolic bone disorder linked
Kai Huang, Jun Qian, Yike Wang, Feng Zhang, Youjia Xu, Qiaocheng Zhai   +5 more
wiley   +1 more source

SR9009 regulates macrophage polarization via the NR1D1/NF-κB axis to ameliorate obesity-associated ulcerative colitis

Frontiers in Gastroenterology
ObjectiveThe incidence of ulcerative colitis (UC) and obesity has risen in recent years, potentially linked through metabolic dysregulation and chronic inflammation.
Zhixue Zheng, Xuan Cai, Yaqi Liu, Jingtao Bi   +3 more
doaj   +1 more source

A Sextuple Knockout Cell Line System to Study the Differential Roles of CRY, PER, and NR1D in the Transcription-Translation Feedback Loop of the Circadian Clock

Frontiers in Neuroscience, 2020
The transcription-translation feedback loop (TTFL) is the core mechanism of the circadian rhythm. In mammalian cells, CLOCK-BMAL1 proteins activate the downstream genes by binding on the E-box sequence of the clock-controlled genes.
Yi-Ying Chiou, Tzu-Ying Li, Yanyan Yang, Aziz Sancar   +3 more
doaj   +1 more source

The aging paradox of Cushing's syndrome: Stress without clear senescence?

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Cushing's syndrome (CS), characterized by chronic endogenous hypercortisolism and disruption of the normal circadian cortisol rhythm, represents a unique human model for investigating the interplay between stress endocrinology and biological aging.
Israel Nunes Silveira, Alexandro Guterres   +1 more
wiley   +1 more source

Elucidation of the anti-arthritic mechanism of Guizhi-Shaoyao-Zhimu decoction by reshaping circadian rhythm

Pharmacological Research
Rheumatoid Arthritis (RA) exhibits pronounced circadian oscillations, with variations in joint stiffness, pain, and swelling following rhythmic patterns.
Xizi He, Runze Li, Xiaohong He, Fan He, Yao Xiao, Xianghong Chen, Yu Lai, Wanyi Guo, Peiyu Liu, Xiao Cai, Xiaonan Yang, Yongkang Shu, Jie Shao, Yulian Chen, Danli Chen, Minqi Quan, Jiaqi Wu, Leyao Xian, Jiayan He, Hong Ren, Zhengmin Chen, Zishao Zhong, Liang Liu, Hudan Pan   +23 more
doaj   +1 more source

Light pollution during pregnancy influences the growth of offspring in rats

Ecotoxicology and Environmental Safety
Objective: To investigate the effects of excessive light exposure during gestation on intrauterine development and early growth of neonates in rats. Methods: Pregnant rats were randomly allocated to three groups: the constant light exposure group, non ...
Baojing Zhao, Zhen Yu, Junjie Sun, Weisheng Cheng, Tao Yu, Yuanyuan Yang, Zhaolian Wei, Zongzhi Yin   +7 more
doaj   +1 more source

Maternal Separation Early in Life Alters the Expression of Genes Npas4 and Nr1d1 in Adult Female Mice: Correlation with Social Behavior

Behavioural Neurology, 2020
Early-life stress affects neuronal plasticity of the brain regions participating in the implementation of social behavior. Our previous studies have shown that brief and prolonged separation of pups from their mothers leads to enhanced social behavior in
Yuliya A. Ryabushkina, Vasiliy V. Reshetnikov, Natalya P. Bondar   +2 more
doaj   +1 more source