Results 71 to 80 of about 4,156 (159)

Nr1d1, an Important Circadian Pathway Regulatory Gene, Is Suppressed By Cigarette Smoke in Murine Lungs

Integrative Cancer Therapies, 2009
Nuclear receptor subfamily 1, group D member 1 ( Nr1d1), also known as Rev-erb-α, belongs to the family of “orphan receptors” and functions as a member of clock gene family. In addition to being an important member of clock circuitry, Nr1d1, also regulates cell proliferation, lipid metabolism, and inflammation and is also touted as a tumor suppressor ...
Vihas T, Vasu, Carroll E, Cross, Kishorchandra, Gohil   +2 more
openaire   +2 more sources

FTO-mediated NR1D1 m6A demethylation contributes to hyperandrogenemia during continuous light–induced circadian disruption

Scientific Reports
N6-methyladenosine (m6A) is a key epigenetic modification closely associated with reproductive physiology; however, its involvement in circadian-related ovarian dysfunction remains unclear.
Tingting Zhou, Yong Tan, Jie Chen, Jiayu Shi, Yuhan Zhang   +4 more
doaj   +1 more source

An antagonistic role of clock genes and lima1 in kidney regeneration

Communications Biology
The circadian clock genes are known important for kidney development, maturation and physiological functions. However, whether and how they play a role in renal regeneration remain elusive.
Xian He, Ziming Wang, Linxi Cheng, Han Wang, Yuhua Sun   +4 more
doaj   +1 more source

Exploring the Mechanism of Sesamin in Treating Mild Alcoholic Liver Disease Based on Transcriptome Sequencing

Natural Product Communications
Background: Sesamin has been shown to prevent and treat alcoholic liver disease (ALD), but the underlying mechanisms remain unclear. This study aims to observe the effects of sesamin on mild ALD and to explore its potential mechanisms.
Moxuan Li, Yundong Wang, Yunqing Peng, Ya Zhang, Le Qin, Hao Rong, Huanhuan Jin, Ye Wang, Zongyuan Hong, Junxiu Zhang   +9 more
doaj   +1 more source

Novel role of NR1D1 and SLC7A5 in gestational diabetes mellitus: regulation of polyamine metabolism

Journal of Diabetes & Metabolic Disorders
A potential link exists between gestational diabetes mellitus (GDM) and polyamines, yet the mechanism of polyamine metabolism-related genes (PMRGs) in GDM remains elusive. This study aims to clarify the relationship between PMRGs and GDM.The study utilized GDM-related datasets (GSE203346, GSE154414) and PMRGs scores. Differential expression analysis on
Wang, Zhiqi, Fang, Guangjuan, Yao, Yanjiao, Wang, Jing   +3 more
openaire   +3 more sources

Circadian rhythm and lithium response in bipolar disorder: Insights from actigraphy and NR1D1 polymorphism

Chronobiology International
Lithium has long been used as a cornerstone mood stabilizer in the treatment of bipolar disorder (BD). However, reliable biomarkers that can predict which patients will respond better to lithium are still lacking. This study aims to evaluate the potential of NR1D1 gene SNP; rs2071427 and actigraphic measurements in predicting lithium response.
Ucak, Ekrem Furkan, Altinbas, Kursat, Kocak, Nadir, Gulec, Ahmet   +3 more
openaire   +3 more sources

Exploring differences in signaling pathways of the circadian clock and neuromodulators in obstructive sleep apnea

Scientific Reports
Obstructive sleep apnea (OSA) is a prevalent disorder characterized by recurring upper airway obstructions, leading to disrupted sleep and systemic complications. The complexity of OSA suggests intricate interactions between neuromodulators and circadian
Szymon Turkiewicz, Marcin Sochal, Marta Ditmer, Adrian Gajewski, Dominik Strzelecki, Piotr Białasiewicz, Maciej Chałubiński, Agata Gabryelska   +7 more
doaj   +1 more source

Impact of exercise and fasting on mitochondrial regulators in human muscle

Translational Exercise Biomedicine
To investigate the impact of acute energetic stress (acute HIIE and fasting) on ERRγ, PPARβ, NR1D1, NR4A1, and TFEB in human skeletal muscle.
Menezes Eveline S., Islam Hashim, Arhen Benjamin B., Simpson Craig A., McGlory Chris, Gurd Brendon J.   +5 more
doaj   +1 more source

NR1D1 Gene [PDF]

, 2020
openaire   +1 more source

NR1D1 wt Allele [PDF]

, 2020
openaire   +1 more source