Results 21 to 30 of about 4,156 (159)

Nuclear receptor subfamily 1 group D member 1 suppresses the proliferation, migration of adventitial fibroblasts, and vascular intimal hyperplasia via mammalian target of rapamycin complex 1/β-catenin pathway

Clinical and Experimental Hypertension, 2023
Background In-stent restenosis hardly limits the therapeutic effect of the percutaneous vascular intervention. Although the restenosis is significantly ameliorated after the application of new drug-eluting stents, the incidence of restenosis remains at a
Ke Peng, Mingliang Wang, Jun Wang, Qiang Wang, De Li, Xiongshan Sun, Yongjian Yang, Dachun Yang   +7 more
doaj   +1 more source

m6A methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis

Pharmacological Research, 2023
The roles of nuclear receptor subfamily 1 group d member 1 (NR1D1) and the circadian clock in liver fibrosis remain unclear. Here, we showed that liver clock genes, especially NR1D1, were dysregulated in mice with carbon tetrachloride (CCl4)-induced ...
Li Chen, Siwei Xia, Feixia Wang, Yuanyuan Zhou, Shuqi Wang, Ting Yang, Yang Li, Min Xu, Ya Zhou, Desong Kong, Zili Zhang, Jiangjuan Shao, Xuefen Xu, Feng Zhang, Shizhong Zheng   +14 more
doaj   +1 more source

Nuclear receptor Rev-erb alpha (Nr1d1) functions in concert with Nr2e3 to regulate transcriptional networks in the retina. [PDF]

PLoS ONE, 2011
The majority of diseases in the retina are caused by genetic mutations affecting the development and function of photoreceptor cells. The transcriptional networks directing these processes are regulated by genes such as nuclear hormone receptors.
Nissa J Mollema, Yang Yuan, Austin S Jelcick, Andrew J Sachs, Désirée von Alpen, Daniel Schorderet, Pascal Escher, Neena B Haider   +7 more
doaj   +1 more source

NR1D1 downregulation in astrocytes induces a phenotype that is detrimental to cocultured motor neurons

The FASEB Journal, 2022
Abstract Nuclear receptor subfamily 1 group D member 1 (NR1D1, also known as Rev‐erbα) is a nuclear transcription factor that is part of the molecular clock encoding circadian rhythms and may link daily rhythms with metabolism and inflammation. NR1D1, unlike most nuclear receptors, lacks a ligand‐dependent activation function domain 2
Killoy, Kelby M., Harlan, Benjamin A., Pehar, Mariana, Vargas, Marcelo R.   +3 more
openaire   +2 more sources

NR1D1 amelioratesMycobacterium tuberculosisclearance through regulation of autophagy [PDF]

Autophagy, 2015
NR1D1 (nuclear receptor subfamily 1, group D, member 1), an adopted orphan nuclear receptor, is widely known to orchestrate the expression of genes involved in various biological processes such as adipogenesis, skeletal muscle differentiation, and lipid and glucose metabolism.
Vemika, Chandra, Ella, Bhagyaraj, Ravikanth, Nanduri, Nancy, Ahuja, Pawan, Gupta   +4 more
openaire   +2 more sources

Application and limitation of a biological clock-based method for estimating time of death in forensic practices

Scientific Reports, 2023
Estimating time of death is one of the most important problems in forensics. Here, we evaluated the applicability, limitations and reliability of the developed biological clock-based method. We analyzed the expression of the clock genes, BMAL1 and NR1D1,
Akihiko Kimura, Yuko Ishida, Mizuho Nosaka, Akiko Ishigami, Hiroki Yamamoto, Yumi Kuninaka, Satoshi Hata, Mitsunori Ozaki, Toshikazu Kondo   +8 more
doaj   +1 more source

High expression of NR1D1 is associated with good prognosis in triple-negative breast cancer patients treated with chemotherapy

Breast Cancer Research, 2019
Background Nuclear receptor subfamily 1, group D, member 1 (NR1D1) is a ligand-regulated nuclear receptor and transcriptional factor. Although recent studies have implicated NR1D1 as a regulator of DNA repair and proliferation in breast cancers, its ...
Hyelin Na, Jinil Han, Na-Lee Ka, Min-Ho Lee, Yoon-La Choi, Young Kee Shin, Mi-Ock Lee   +6 more
doaj   +1 more source

Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line. [PDF]

PLoS ONE, 2015
We have previously shown that the nuclear receptor, NR1D1, is a cofactor in ApoA-IV-mediated downregulation of gluconeogenesis. Nuclear receptor, NR4A1, is involved in the transcriptional regulation of various genes involved in inflammation, apoptosis ...
Xiaoming Li, Min Xu, Fei Wang, Yong Ji, W Sean DavidsoN, Zongfang Li, Patrick Tso   +6 more
doaj   +1 more source

Differential expression of NR1D1 in amyotrophic lateral sclerosis.

, 2022
Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression ...
openaire   +1 more source

Transcriptome analysis of clock disrupted cancer cells reveals differential alternative splicing of cancer hallmarks genes

npj Systems Biology and Applications, 2022
Emerging evidence points towards a regulatory role of the circadian clock in alternative splicing (AS). Whether alterations in core-clock components may contribute to differential AS events is largely unknown.
Deeksha Malhan, Alireza Basti, Angela Relógio   +2 more
doaj   +1 more source