Results 11 to 20 of about 4,156 (159)

Targeting NR1D1 in organ injury: challenges and prospects

Military Medical Research, 2023
Nuclear receptor subfamily 1, group D, member 1 (NR1D1, also known as REV-ERBα) belongs to the nuclear receptor (NR) family, and is a heme-binding component of the circadian clock that consolidates circadian oscillators.
Zi-Yin Zhang-sun, Xue-Zeng Xu, Germaine Escames, Wang-Rui Lei, Lin Zhao, Ya-Zhe Zhou, Ye Tian, Ya-Nan Ren, Darío Acuña-Castroviejo, Yang Yang   +9 more
doaj   +4 more sources

NR1D1 controls skeletal muscle calcium homeostasis through myoregulin repression

JCI Insight, 2022
The sarcoplasmic reticulum (SR) plays an important role in calcium homeostasis. SR calcium mishandling is described in pathological conditions, such as myopathies. Here, we investigated whether the nuclear receptor subfamily 1 group D member (NR1D1, also
Alexis Boulinguiez, Christian Duhem, Alicia Mayeuf-Louchart, Benoit Pourcet, Yasmine Sebti, Kateryna Kondratska, Valérie Montel, Stéphane Delhaye, Quentin Thorel, Justine Beauchamp, Aurore Hebras, Marion Gimenez, Marie Couvelaere, Mathilde Zecchin, Lise Ferri, Natalia Prevarskaya, Anne Forand, Christel Gentil, Jessica Ohana, France Piétri-Rouxel, Bruno Bastide, Bart Staels, Helene Duez, Steve Lancel   +23 more
doaj   +8 more sources

NR1D1 suppressed the growth of ovarian cancer by abrogating the JAK/STAT3 signaling pathway [PDF]

BMC Cancer, 2021
Background Nuclear receptor subfamily 1 group D member 1 (NR1D1), a nuclear receptor associated with a variety of physiological processes, has a low level in ovarian cancer tissues compared with adjacent normal tissues.
Huailin Wang, Yan Fu
doaj   +3 more sources

NR1D1 deficiency in the tumor microenvironment promotes lung tumor development by activating the NLRP3 inflammasome

Cell Death Discovery, 2023
Nuclear receptor Rev-erbα (NR1D1) is a major negative regulator of the circadian clock. Numerous studies have investigated the role of circadian clock-related factors in the tumorigenesis of multiple cancer types, but little is known about the role of ...
Sun Mi Kim, Yoon Jeon, Ji Yun Jang, Ho Lee   +3 more
doaj   +3 more sources

Investigation of associations between NR1D1, RORA and RORB genes and bipolar disorder. [PDF]

PLoS ONE, 2015
Several genes that are involved in the regulation of circadian rhythms are implicated in the susceptibility to bipolar disorder (BD). The current study aimed to investigate the relationships between genetic variants in NR1D1 RORA, and RORB genes and BD ...
Yin-Chieh Lai, Chung-Feng Kao, Mong-Liang Lu, Hsi-Chung Chen, Po-Yu Chen, Chien-Hsiun Chen, Winston W Shen, Jer-Yuarn Wu, Ru-Band Lu, Po-Hsiu Kuo   +9 more
doaj   +4 more sources

Clock Gene Nr1d1 Alleviates Retinal Inflammation Through Repression of Hmga2 in Microglia

Journal of Inflammation Research, 2021
Zhijie Wang,1,2 Yinhua Huang,1,2 Feixue Chu,3 Shangli Ji,2 Kai Liao,1,2 Zekai Cui,2 Jiansu Chen,1,2,4,5 Shibo Tang1,2,6 1Aier School of Ophthalmology, Central South University, Changsha, People’s Republic of China; 2Aier Eye Institute, Aier Eye Hospital ...
Wang Z, Huang Y, Chu F, Ji S, Liao K, Cui Z, Chen J, Tang S   +7 more
doaj   +4 more sources

Dual control of liver regeneration by Nr1d1 homeostasis and Klf2 checkpoint. [PDF]

Cell Death Discov
Abstract Following extensive liver resections, diminished liver regeneration impairs the maintenance or restoration of sufficient functional liver mass. Currently, effective therapies to restore liver regeneration are lacking, rendering liver transplantation the sole treatment option for end-stage liver disease.
Ye B, Xie D, Shen W, Yue M, Jin Q, Guo X, Zhang Y, Li P, Zhao Z.   +8 more
europepmc   +2 more sources

NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis [PDF]

Cell Death & Disease, 2020
AbstractRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia, pannus formation, and cartilage and bone destruction. Nuclear receptor subfamily 1 group D member 1 (NR1D1) functions as a transcriptional repressor and plays a vital role in inflammatory reactions.
Liu, Hui, Zhu, Yuanli, Gao, Yutong, Qi, Dahu, Zhao, Liming, Zhao, Libo, Liu, Changyu, Tao, Tenghui, Zhou, Chuankun, Sun, Xuying, Guo, Fengjing, Xiao, Jun   +11 more
openaire   +2 more sources

Nuclear Receptors (PPARs, REV-ERBs, RORs) and Clock Gene Rhythms in Goldfish (Carassius auratus) Are Differently Regulated in Hypothalamus and Liver

Frontiers in Physiology, 2022
The circadian system is formed by a network of oscillators located in central and peripheral tissues that are tightly linked to generate rhythms in vertebrates to adapt the organism to the cyclic environmental changes.
Miguel Gómez-Boronat, Nuria De Pedro, Ángel L. Alonso-Gómez, María J. Delgado, Esther Isorna   +4 more
doaj   +1 more source

Low expression of NR1D1 and NR2E3 is associated with advanced features of retinoblastoma

International Ophthalmology, 2023
Abstract Purpose To investigate the expression of nuclear receptor subfamily 1 group D member 1 (NR1D1) and nuclear receptor subfamily 2 group E Member 3 (NR2E3) in retinoblastoma (RB) and their correlation with the clinical and pathological features of RB.
Ding, Jie, Sun, Jie, Ma, Rui-Qi, Zheng, Ke, Han, Yi-Nan   +4 more
openaire   +2 more sources