Regulation of Stemness by NR1D2 in Colorectal Cancer [PDF]
BiomedicinesBackground: Nuclear Receptor Subfamily 1 Group D Member 2 (NR1D2), a transcription factor that regulates the circadian clock, has been described as an oncogene in colorectal cancer (CRC). In several types of cancer, NR1D2 regulates cancer progression and
Josefa Leon +2 more
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Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways [PDF]
EMBO JournalHormone therapy resistance and the ensuing aggressive tumor progression present a significant clinical challenge. However, the mechanisms underlying the induction of tumor malignancy upon inhibition of steroid hormone signaling remain poorly understood ...
Du Kong, Yanxiao Zhang, Qi Xie
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LINC01224 facilitates the proliferation and inhibits the radiosensitivity of melanoma cells through the miR‐193a‐5p/NR1D2 axis [PDF]
Kaohsiung Journal of Medical Sciences, 2022 Melanoma is a skin cancer characterized by early metastasis and high mortality. Radiotherapy is a common treatment for melanoma in patients. Long noncoding RNAs play pivotal roles in regulating the radiosensitivity of many tumors, including melanomas. In
Yi Zheng
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Evaluation of rare NR1D2 variants in MODY-X: clinical, genetic, and in silico insights [PDF]
Journal of Endocrinological InvestigationAbstract Purpose The objective of this study was to investigate the protein-coding regions of the NR1D2 gene in patients clinically diagnosed with maturity-onset diabetes of the young (MODY), including those without pathogenic variants in known MODY genes (MODY-X), and to characterize the ...
Sükran Poyrazoğlu +2 more
exaly +4 more sources
Ferroptosis in glaucoma: Identification of key genes NR1D2 and AKR1C3 based on transcriptome bioinformatics analysis [PDF]
Medicine (United States)Glaucoma, a leading cause of blindness, involves retinal ganglion cell death linked to ferroptosis, an iron-dependent form of cell death. This study analyzed GEO datasets (GSE9944 and GSE2378) to identify ferroptosis-related genes in glaucoma. Least absolute shrinkage and selection operator and support vector machine-recursive feature elimination ...
Zhu Huang
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Nuclear receptor subfamily 1 group D member 2 induces chemoresistance in ovarian cancer by regulating ferroptosis and immune infiltration [PDF]
Discover OncologyOvarian cancer is known for its high recurrence rates and poor prognosis, primarily due to chemoresistance, which significantly limits treatment options.
Ning Shao, Sun Huizhen
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Identification of immune-related prognostic biomarkers in lung squamous cell carcinoma microenvironment [PDF]
Frontiers in ImmunologyBackgroundLung squamous cell carcinoma (LUSC) is a leading cause of cancer-related mortality. Although immunotherapy has recently demonstrated clinical benefits, the biological roles of immune-related genes (IRGs) in LUSC remain insufficiently understood.
Zhihao Wang +2 more
doaj +2 more sources
Regulation of Circadian Genes Nr1d1 and Nr1d2 in Sex-Different Manners during Liver Aging
International Journal of Molecular Sciences, 2022 Background: Circadian rhythm is associated with the aging process and sex differences; however, how age and sex can change circadian regulation systems remains unclear. Thus, we aimed to evaluate age- and sex-related changes in gene expression and identify sex-specific target molecules that can regulate aging.
Hee Jin Jung +2 more
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Impacts of exercise, renin-angiotensin system modulation or both on skeletal muscle circadian gene expression. [PDF]
Exp PhysiolAbstract Ageing negatively affects quality of life and healthspan, and interventions are needed to slow this progressive decline. Previously, we have demonstrated the potential functional benefits of combining a genetically modified probiotic (GMP) targeting the non‐canonical arm of the renin–angiotensin system (RAS) with exercise training.
Zumbro EL +8 more
europepmc +2 more sources
Effects and Mechanisms of Wrist-Ankle Acupuncture on Inflammatory Pain in the Rat Gastrocnemius Muscle [PDF]
Journal of Pain ResearchTingting Mai,1,* Mengcheng Cai,1,* Yuhan Tian,1,* Lanyu Jiang,1 Fanfu Fang,1 Wei Gu2 1Department of Rehabilitation Medicine, The First Affiliated Hospital of Naval Medical University, Shanghai, People’s Republic of China; 2School ...
Mai T +5 more
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