Results 31 to 40 of about 2,154 (127)

A Sextuple Knockout Cell Line System to Study the Differential Roles of CRY, PER, and NR1D in the Transcription-Translation Feedback Loop of the Circadian Clock

Frontiers in Neuroscience, 2020
The transcription-translation feedback loop (TTFL) is the core mechanism of the circadian rhythm. In mammalian cells, CLOCK-BMAL1 proteins activate the downstream genes by binding on the E-box sequence of the clock-controlled genes.
Yi-Ying Chiou, Tzu-Ying Li, Yanyan Yang, Aziz Sancar   +3 more
doaj   +1 more source

Integrated bioinformatics, network pharmacology, and artificial intelligence to predict the mechanism of celastrol against muscle atrophy caused by colorectal cancer

Frontiers in Genetics, 2022
Muscle atrophy due to colorectal cancer severely reduces the quality of life and survival time of patients. However, the underlying causative mechanisms and therapeutic agents are not well understood.
Ming Wu, Yan Zhang
doaj   +1 more source

Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection [PDF]

Autophagy, 2020
Burkholderia pseudomallei: which causes melioidosis with high mortality in humans, has become a global public health concern. Recently, infection-driven lipid droplet accumulation has been related to the progression of host-pathogen interactions, and its contribution to the pathogenesis of infectious disease has been investigated. Here, we demonstrated
Mengling Tang, Zhiqiang Hu, Chenglong Rao, Jiangao Chen, Siqi Yuan, Jiangang Zhang, Chan Mao, Jingmin Yan, Yupei Xia, Meijuan Zhang, Juanjuan Yue, Yang Xiang, Jianping Xie, Xuhu Mao, Qian Li   +14 more
openaire   +2 more sources

De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects. [PDF]

PLoS Genetics, 2016
Congenital heart disease (CHD) has a complex genetic etiology, and recent studies suggest that high penetrance de novo mutations may account for only a small fraction of disease.
James R Priest, Kazutoyo Osoegawa, Nebil Mohammed, Vivek Nanda, Ramendra Kundu, Kathleen Schultz, Edward J Lammer, Santhosh Girirajan, Todd Scheetz, Daryl Waggott, Francois Haddad, Sushma Reddy, Daniel Bernstein, Trudy Burns, Jeffrey D Steimle, Xinan H Yang, Ivan P Moskowitz, Matthew Hurles, Richard P Lifton, Debbie Nickerson, Michael Bamshad, Evan E Eichler, Seema Mital, Val Sheffield, Thomas Quertermous, Bruce D Gelb, Michael Portman, Euan A Ashley   +27 more
doaj   +1 more source

NR1D2 Accelerates Hepatocellular Carcinoma Progression by Driving the Epithelial-to-Mesenchymal Transition.

OncoTargets and therapy, 2020
A poor prognosis owing to cancer invasion and metastasis, hepatocellular carcinoma (HCC) is one of the leading causes of malignancy deaths worldwide. A dominant epithelial-to-mesenchymal transition or EMT function in tumour metastasis is substantially evidenced.
Tong,Hui, Liu,Xiaohui, Li,Tao, Qiu,Weihua, Peng,Chenghong, Shen,Baiyong, Zhu,Zhecheng   +6 more
openaire   +3 more sources

Circadian rhythms in septic shock patients

Annals of Intensive Care, 2021
Background Despite the intensive efforts to improve the diagnosis and therapy of sepsis over the last decade, the mortality of septic shock remains high and causes substantial socioeconomical burden of disease. The function of immune cells is time-of-day-
Gunnar Lachmann, Bharath Ananthasubramaniam, Viktor A. Wünsch, Lara-Marie Scherfig, Clarissa von Haefen, Cornelia Knaak, Andreas Edel, Lukas Ehlen, Barbara Koller, Anton Goldmann, Hanspeter Herzel, Achim Kramer, Claudia Spies   +12 more
doaj   +1 more source

Altered Expression of Circadian Clock Genes in Patients with Atrial Fibrillation Is Associated with Atrial High-Rate Episodes and Left Atrial Remodeling

Diagnostics, 2021
A prominent circadian variation is present in atrial fibrillation (AF) attacks that may be related to the expression of circadian clock genes. Little is known about the expression of circadian clock genes in AF.
Yung-Lung Chen, Jiin-Haur Chuang, Hui-Ting Wang, Huang-Chung Chen, Wen-Hao Liu, Ming-Yu Yang   +5 more
doaj   +1 more source

Mechanism of matrine inhibiting retinoblastoma cell growth by downregulating NR1D2 to regulate phosphorylation of the PI3K/AKT signaling pathway

Scientific Reports
Qian Zheng
exaly   +2 more sources

Prognostic values of the core components of the mammalian circadian clock in prostate cancer [PDF]

PeerJ, 2021
Background Prostate cancer (PC) is one of the most common malignancies in males. Extensive and complex connections between circadian rhythm and cancer were found.
Wenchang Yue, Xiao Du, Xuhong Wang, Niu Gui, Weijie Zhang, Jiale Sun, Jiawei You, Dong He, Xinyu Geng, Yuhua Huang, Jianquan Hou   +10 more
doaj   +2 more sources

Differential expression of NR1D2 in cancer of the skin: malignant melanoma.

, 2023
Skin cancer is diagnosed in nearly 1.5 million patients each year (1). While patients with basal and squamous cell carcinomas are provided with 5-year survival rates at nearly 100% and 90%, respectively, patients diagnosed with cutaneous melanoma (metastatic melanoma) are provided 5-year survival rates at 91.4% at stage I and 24.6% at stage IV (2-5 ...
openaire   +1 more source