Results 41 to 50 of about 2,154 (127)

Transcriptomic Analysis Reveals Circadian Rhythm Homeostasis in Pearl Gentian Grouper under Acute Hypoxia

Fishes, 2023
Oxygen level is an important environmental factor affecting the circadian rhythm. However, little is known about the molecular mechanism by which clock genes regulate the circadian rhythm in fish under hypoxia. To explore changes in the transcription and
Ren-Xie Wu, Yan-Shan Liang, Su-Fang Niu, Jing Zhang, Bao-Gui Tang, Zhen-Bang Liang   +5 more
doaj   +1 more source

Analysis of miRNA expression profiles in the liver of ClockΔ19 mutant mice [PDF]

PeerJ, 2019
The circadian clock controls the physiological functions of many tissues including the liver via an autoregulatory transcriptional−translational feedback loop, of which CLOCK is a core positive component.
Yanli Wang, Ke Lv, Mei Zhao, Hailong Chen, Guohua Ji, Yongliang Zhang, Tingmei Wang, Hongqing Cao, Yinghui Li, Lina Qu   +9 more
doaj   +2 more sources

Investigation of a non-invasive method of assessing the equine circadian clock using hair follicle cells

Journal of Circadian Rhythms, 2012
Background A comprehensive understanding of the equine circadian clock involves the evaluation of circadian clock gene expression. A non-invasive and effective method for detecting equine clock gene expression has yet to be established.
Watts Lisa M, Browne John A, Murphy Barbara A   +2 more
doaj   +1 more source

Diurnal Preference Predicts Phase Differences in Expression of Human Peripheral Circadian Clock Genes

Journal of Circadian Rhythms, 2015
Background: Circadian rhythms play an integral role in human behavior, physiology and health. Individual differences in daily rhythms (chronotypes) can affect individual sleep-wake cycles, activity patterns and behavioral choices. Diurnal preference, the
Andrew Ferrante, David Gellerman, Ahmet Ay, Kerri Woods, Allan Michael Filipowicz, Kriti Jain, Neil Bearden, Krista Kenyon Ingram   +7 more
doaj   +1 more source

Transcriptomic profiling of TLR-7-mediated immune-challenge in zebrafish embryos in the presence and absence of glucocorticoid-induced immunosuppression

Ecotoxicology and Environmental Safety, 2023
Although numerous studies imply a correlation between chemical contamination and an impaired immunocompetence of wildlife populations, the assessment of immunomodulatory modes of action is currently not covered in the regulatory requirements for the ...
Benedikt Luckner, Fabian Essfeld, Steve U. Ayobahan, Elke Richling, Elke Eilebrecht, Sebastian Eilebrecht   +5 more
doaj   +1 more source

RHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine

Advanced Science, EarlyView.
RHINO (RHythmic Interacting Network for multi‐Omics) is an integrative framework that maps circadian regulation across diverse genetic and disease contexts and prioritizes druggable circadian targets. Released as an AI‐powered interactive web portal, RHINO unifies genetic, regulatory, disease, and drug–target information, enabling context‐specific ...
Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López‐Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan   +12 more
wiley   +1 more source

The Tibetan medicine Zuotai influences clock gene expression in the liver of mice [PDF]

PeerJ, 2016
Background. The circadian clock is involved in drug metabolism, efficacy and toxicity. Drugs could in turn affect the biological clock as a mechanism of their actions.
Huan Li, Wen-Kai Li, Yuan-Fu Lu, Li-Xin Wei, Jie Liu   +4 more
doaj   +2 more sources

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Expression Landscape and Circadian Regulation of lncRNAs in the Kidney

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Recent multi‐omics work shows that the diurnal rhythmicity of kidney function is associated with circadian oscillations in renal mRNA, protein and metabolite abundances. Yet circadian regulation of renal lncRNAs, which are emerging as important modulators of diverse (patho)physiological processes, remains largely unexplored. Here, we provide a
Leonore Wigger, Fanny Durussel, Muriel Auberson, Dmitri Firsov, Yohan Bignon   +4 more
wiley   +1 more source

Identification of genomic regions, genetic variants and gene networks regulating candidate genes for lipid metabolism in pig muscle

Animal, 2023
The intramuscular fat content and fatty acid composition of porcine meat have a significant impact on its quality and nutritional value. This research aimed to investigate the expression of 45 genes involved in lipid metabolism in the longissimus dorsi ...
M. Passols, F. Llobet-Cabau, C. Sebastià, A. Castelló, J. Valdés-Hernández, L. Criado-Mesas, A. Sánchez, J.M. Folch   +7 more
doaj   +1 more source