Results 51 to 60 of about 2,154 (127)
Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion
Frontiers in Immunology, 2019 Although dysfunctional circadian clock has emerged as a hallmark of cancer, fundamental gaps remain in our understanding of the underlying mechanisms involved.
Yingcheng Wu +6 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 11, 15 June 2026.During the development of OA, elevated RORα in chondrocytes inhibits β‐catenin degradation in the cytoplasm by activating the Wnt/β‐catenin signaling pathway. When β‐catenin protein accumulates excessively in the cytoplasm, it is transferred to the nucleus and binds to the cytosolic TCF/LEF transcriptional complex, which activates downstream target ...
Ruijue Zhu +9 more
wiley +1 more source
BMC Genomics, 2021 Background As the critical tissue of the central nervous system, the brain has been found to be involved in gonad development. Previous studies have suggested that gonadal fate may be affected by the brain.
Xufang Shen +6 more
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NAD+‒circadian rhythm coupling in dementia
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang +7 more
wiley +1 more source
Iron metabolism and preeclampsia: new insights from bioinformatics analysis
The Journal of Maternal-Fetal & Neonatal MedicineObjective Preeclampsia (PE) is a multifactorial systemic pregnancy disease, in which iron metabolism and ferroptosis play significant roles during its pathogenesis.
Xijiao Guo, Sha Li, Guoping Xiong
doaj +1 more source
Identification of a prognostic immune‐related signature for small cell lung cancer
Cancer Medicine, 2021 Purpose As a subgroup of lung cancer, small cell lung cancer (SCLC) is characterized by a short tumor doubling time, high rates of early occurred distant cancer spread, and poor outcomes. Despite its exquisite sensitivity to chemotherapy and radiotherapy,
Qi Xie +9 more
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Hematology, Transfusion and Cell Therapy, 2023 Objectives: Acute Myeloid Leukemia (AML) is a complex and heterogeneous disease characterized by the blockage of blood cell maturation, leading to uncontrolled proliferation of immature malignant cells.
M Brandão +3 more
doaj +1 more source
FEBS Letters, Volume 600, Issue 6, Page 847-861, March 2026.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Identification of ferroptosis‐related genes in type 2 diabetes mellitus based on machine learning
Immunity, Inflammation and Disease, 2023 Background Type 2 diabetes mellitus (T2DM), which has a high incidence and several harmful consequences, poses a severe danger to human health. Research on the function of ferroptosis in T2DM is increasing.
Sen Wang +6 more
doaj +1 more source
An Overview of the Polymorphisms of Circadian Genes Associated With Endocrine Cancer
Frontiers in Endocrinology, 2019 A major consequence of the world industrialized lifestyle is the increasing period of unnatural light in environments during the day and artificial lighting at night.
Sonia Morales-Santana +6 more
doaj +1 more source