Results 71 to 80 of about 2,154 (127)

Circadian pathway genetic variation and cancer risk: evidence from genome-wide association studies

BMC Medicine, 2018
Background Dysfunction of the circadian clock and single polymorphisms of some circadian genes have been linked to cancer susceptibility, although data are scarce and findings inconsistent.
Simone Mocellin, Saveria Tropea, Clara Benna, Carlo Riccardo Rossi   +3 more
doaj   +1 more source

Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis.

PLoS ONE, 2017
Increased risk of developing metabolic syndrome (MetS) has been associated with the circadian clock genes. In this study, we assessed whether 29 circadian clock-related genes (including ADCYAP1, ARNTL, ARNTL2, BHLHE40, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E ...
Eugene Lin, Po-Hsiu Kuo, Yu-Li Liu, Albert C Yang, Chung-Feng Kao, Shih-Jen Tsai   +5 more
doaj   +1 more source

Systems genetics of influenza A virus-infected mice identifies TRIM21 as a critical regulator of pulmonary innate immune response

Virus Research
Tripartite motif 21 (TRIM21) is a cytosolic Fc receptor that targets antibody-bound, internalized pathogens for destruction. Apart from this intrinsic defense role, TRIM21 is implicated in autoimmune diseases, inflammation, and autophagy.
Zhuoyuan Alex Li, Akhilesh Kumar Bajpai, Ruixue Wang, Yaxin Liu, Richard J. Webby, Esther Wilk, Weikuan Gu, Klaus Schughart, Kui Li, Lu Lu   +9 more
doaj   +1 more source

Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms

eLife
Aging is associated with a number of physiologic changes including perturbed circadian rhythms; however, mechanisms by which rhythms are altered remain unknown. To test the idea that circulating factors mediate age-dependent changes in peripheral rhythms,
Jessica E Schwarz, Antonijo Mrčela, Nicholas F Lahens, Yongjun Li, Cynthia Hsu, Gregory R Grant, Carsten Skarke, Shirley L Zhang, Amita Sehgal   +8 more
doaj   +1 more source

Oxygen is an essential gasotransmitter directly sensed via protein gasoreceptors

Animal Models and Experimental Medicine
The current restrictive criteria for gasotransmitters exclude oxygen (O2) as a gasotransmitter in vertebrates. In this manuscript, I propose a revision of gasotransmitter criteria to include O2 per se as a signaling molecule and 'essential ...
Savani Anbalagan
doaj   +1 more source

Regulatory effect of Procambarus clarkii shell bioactive peptides on muscle antioxidant capacity and circadian rhythm of Pelodiscus sinensis

Shipin yu jixie
ObjectiveTo analyze the effects of Procambarus clarkii shell bioactive peptides (PCSBP) on the growth performance, muscle antioxidant capacity, and circadian rhythm related gene expression of Pelodiscus sinensis.MethodsIn this experiment, different ...
YANG Saijie, LI Honghui, HUANG Chao, YANG Hucheng, LEI Yanli, ZHOU Jie   +5 more
doaj   +1 more source

Novel CLOCK and NR1D2 variants in 64 sighted Japanese individuals with non-24-hour sleep–wake rhythm disorder

SLEEP, 2023
Akiko Hida, Aritoshi Iida, Motoki Ukai, Hiroshi Kadotani, Makoto Uchiyama, Takashi Ebisawa, Yuichi Inoue, Shingo Kitamura, Kazuo Mishima   +8 more
openaire   +2 more sources

Exploration and Validation of Potential Biomarkers and Therapeutic Targets in Ferroptosis of Asthma

Journal of Asthma and Allergy, 2023
Yanqing Xing,1 Liting Feng,1 Yangdou Dong,2 Yupeng Li,1 Lulu Zhang,1 Qiannan Wu,1 Rujie Huo,1 Yanting Dong,1 Xinrui Tian,1 Xinli Tian3 1Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University, Taiyuan ...
Xing Y, Feng L, Dong Y, Li Y, Zhang L, Wu Q, Huo R, Dong Y, Tian X, Tian X   +9 more
doaj  

NR1D2 Gene [PDF]

, 2020
openaire   +1 more source

NR1D2 wt Allele [PDF]

, 2020
openaire   +1 more source