Results 11 to 20 of about 2,154 (127)

Unveiling tumor senescence-driven prognostic heterogeneity via MALISS in stage II/III colorectal cancer [PDF]

Frontiers in Immunology
BackgroundPrognostic heterogeneity in stage II/III colorectal cancer (CRC) challenges clinical management, yet effective prognostic stratification is still lacking.
Xinyu Liu, Xinyu Liu, Xinyu Liu, Bingyao Liu, Yuhao Tong, Xingyu Zhu, Xingyu Zhu, Xingyu Zhu, Yaodong Sang, Yaodong Sang, Yaodong Sang, Feng Gao, Xiangyun Niu, Youyong Tang, Kang Xu, Kang Xu, Hao Chen, Wei Chong, Wei Chong, Wei Chong, Wei Chong, Leping Li, Leping Li, Leping Li   +23 more
doaj   +2 more sources

Optimised Stable Lighting Strengthens Circadian Clock Gene Rhythmicity in Equine Hair Follicles

Animals, 2023
Hair follicles (HF) represent a useful tissue for monitoring the circadian clock in mammals. Irregular light exposure causes circadian disruption and represents a welfare concern for stabled horses.
John Sheridan, John Browne, Barbara Murphy   +2 more
exaly   +3 more sources

T Cell Exhaustion and Dendritic Cell-Mediated Tertiary Lymphoid Structures (TLSs) Modulation Affect Response to Neoadjuvant Chemoradiotherapy in Microsatellite Stable Rectal Cancer. [PDF]

Adv Sci (Weinh)
Using multi‐omics analysis, this study demonstrates that immune characteristics of the tumor microenvironment, rather than mutational profiles, are more strongly correlated with treatment response. Specifically, early exhausted T cells and tertiary lymphoid structures regulation by LAMP3⁺ dendritic cells emerge as key predictors of favorable outcomes ...
Wang M, Shi J, Xu K, Yu L, Yin X, Wang J, Zhu L, Yang X, Qian J, Wang W, Zhu L, Dai X, Zhao Z, Wu J, Li D, Hu Z, Huang Q, Li X.   +17 more
europepmc   +2 more sources

Circadian Reprogramming of Protein Homeostasis and Glycolipid Metabolism in Diabetic Nephropathy. [PDF]

FASEB Bioadv
Using time‐series transcriptomic profiling of diabetic mouse kidneys, our study reveals substantial circadian disruption in diabetic nephropathy, with significant impacts on protein homeostasis and glycolipid metabolism. Furthermore, our findings highlight the potential influence of circadian system dysregulation on the disorder of fatty acid ...
Li XQ, Cheng L, Chen TF, Ma YN, Wang LY, Li XH, Fu TY, Xiao J, Zhao ZZ.   +8 more
europepmc   +2 more sources

DNA Methylation-Related circRNA_0116449 Is Involved in Lipid Peroxidation in Traumatic Brain Injury

Frontiers in Molecular Neuroscience, 2022
Circular ribonucleic acid (circRNA) has a critical effect in central nervous diseases; however, the exact role of circRNAs in human traumatic brain injury (TBI) remains elusive. Epigenetic modifications, such as DNA methylation, can modify the mRNA level
Ping Zheng, Dabin Ren
exaly   +3 more sources

Altered peripheral CRY1 gene expression may contribute to both organic and functional gastrointestinal disease. [PDF]

Exp Physiol
ABSTRACT Gastrointestinal conditions such as irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) are characterized by alterations in physiological and immune functions. Given the circadian clock influences gastrointestinal physiology and immunity, we hypothesized that the peripheral circadian clock is altered in these patients and ...
Fowler S, Paech GM, Hoedt EC, Pryor JC, Nieva C, Bruce JK, Nair PM, Eslick GD, Sherwin S, Pockney P, Talley NJ, Burns GL, Keely S.   +12 more
europepmc   +2 more sources

Ferroptosis and chemotherapy resistance in ovarian cancer: molecular mechanisms and therapeutic opportunities [PDF]

Journal of Ovarian Research
Ovarian cancer remains the most lethal gynecologic malignancy, with acquired platinum resistance accounting for the majority of treatment failures. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a
Shuqing Li, Lina Yang, Zhiling Zhu
doaj   +2 more sources

Linkage of the Nuclear Hormone Receptor Genes NR1D2, THRB, and RARB: Evidence for an Ancient, Large-Scale Duplication

Genomics, 1999
The THRA gene encoding thyroid hormone receptor alpha shares an unusual partial overlap with the NR1D1 gene encoding the orphan receptor Rev-ErbAalpha. Though THRA and NR1D1 have close relatives in THRB and NR1D2, which encode TRbeta and Rev-ErbAbeta, these beta isoforms do not share an analogous overlap.
David Moore, Young Sang Koh
exaly   +3 more sources

Proanthocyanidin-Rich Cranberry Extract Lowers Glycemia in Established Obesity by Delaying Glucose Absorption. [PDF]

FASEB J
Schematic summary of the metabolic effects and proposed mechanisms of action of proanthocyanidin‐rich cranberry extract (PRCE) supplementation in mice with established diet‐induced obesity housed under thermoneutral (30°C) or cold‐exposed (10°C) conditions.
Beji S, Mouchiroud M, Tribouillard L, Efole B, Perazza L, Favereaux L, Poirier A, Idris W, Gélinas Y, Varin TV, Rovère C, Anhê FF, Picard F, Laplante M, Marette A, Michaud A, Caron A.   +16 more
europepmc   +2 more sources

Time-Restricted Feeding Alters Behavior in a Sex-Specific Manner in Mice With Neuropathic Pain. [PDF]

Mol Nutr Food Res
Time‐restricted feeding (TRF) alleviates anxiety‐like behavior in male mice with neuropathic pain (NP), but not in females. Upon nerve injury, TRF altered the diurnal expression of transcripts in the hypothalamus. These findings suggest that TRF should be explored as a new therapeutic approach to alleviate the comorbid anxiety in NP.
Wen M, Dai W, Kalso E, Palada V.
europepmc   +2 more sources