Results 31 to 40 of about 36,777 (126)

IL-6 deletion decreased REV-ERBα protein and influenced autophagy and mitochondrial markers in the skeletal muscle after acute exercise

Frontiers in Immunology, 2022
Interleukin 6 (IL-6) acts as a pro and anti-inflammatory cytokine, has an intense correlation with exercise intensity, and activates various pathways such as autophagy and mitochondrial unfolded protein response. Also, IL-6 is interconnected to circadian
Ana P. Pinto, Vitor R. Muñoz, Alisson L. da Rocha, Rafael L. Rovina, Gustavo D. Ferrari, Luciane C. Alberici, Fernando M. Simabuco, Fernando M. Simabuco, Giovana R. Teixeira, Giovana R. Teixeira, José R. Pauli, Leandro P. de Moura, Dennys E. Cintra, Eduardo R. Ropelle, Ellen C. Freitas, Donato A. Rivas, Adelino S. R. da Silva, Adelino S. R. da Silva   +17 more
doaj   +1 more source

RORα and REV-ERBα are Associated With Clinicopathological Parameters and are Independent Biomarkers of Prognosis in Gastric Cancer

Technology in Cancer Research & Treatment, 2021
Retinoid-related orphan receptor alpha (RORα) and nuclear receptor subfamily 1 group D member 1 (REV-ERBα) play critical roles in many human cancers.
Xiaoshan Wang MM, Ru Jia MM, Ke Chen MM, Jingjing Wang MM, Kai Jiang MM, Zhengguang Wang MD   +5 more
doaj   +1 more source

Histological, antioxidant, apoptotic and transcriptomic responses under cold stress and the mitigation of blue wavelength light of zebrafish eyes

Aquaculture Reports, 2022
As global climate changes, severely temperature variations have significant impacts on survival and development of fish. While the potential effects of light wavelength on cold shock and associated mechanisms remain largely unknown in fish.
Li-Bin Peng, Dan Wang, Tao Han, Zhengshun Wen, Xiao Cheng, Qing-Ling Zhu, Jia-Lang Zheng, Ping Wang   +7 more
doaj   +1 more source

DNA methylation of the glucocorticoid receptor gene predicts substance use in adolescence: longitudinal data from over 1000 young individuals

Translational Psychiatry, 2021
Early life stress has been linked to increased methylation of the Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1) gene, which codes for the glucocorticoid receptor.
Elena Raffetti, Philippe Anastasios Melas, Anton Jonatan Landgren, Filip Andersson, Yvonne Forsell, Catharina Lavebratt, Maria Rosaria Galanti   +6 more
doaj   +1 more source

FTO-mediated NR1D1 m6A demethylation contributes to hyperandrogenemia during continuous light–induced circadian disruption

Scientific Reports
N6-methyladenosine (m6A) is a key epigenetic modification closely associated with reproductive physiology; however, its involvement in circadian-related ovarian dysfunction remains unclear.
Tingting Zhou, Yong Tan, Jie Chen, Jiayu Shi, Yuhan Zhang   +4 more
doaj   +1 more source

Light Exposure, Physical Activity, and Indigeneity Modulate Seasonal Variation in NR1D1 (REV-ERBα) Expression

Biology
Nuclear receptor subfamily 1 group D member 1 (NR1D1 or REV-ERBα) is a crucial element of the circadian clock’s transcriptional and translational feedback loop.
Denis Gubin, Sergey Kolomeichuk, Konstantin Danilenko, Oliver Stefani, Alexander Markov, Ivan Petrov, Kirill Voronin, Marina Mezhakova, Mikhail Borisenkov, Aislu Shigabaeva, Julia Boldyreva, Julianna Petrova, Dietmar Weinert, Germaine Cornelissen   +13 more
doaj   +1 more source

miR-185-5p facilitates intracellular Mycobacterium growth via inhibiting macrophage autophagy

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·To explore the regulatory effect of miR-185-5p on autophagy in Mycobacterium-infected macrophages and its influence on the survival of intracellular Mycobacterium.Methods·Macrophages derived from human monocytic-leukemia (THP-1) cells were ...
WU Qiqi, WANG Hao, LIN Li, YAN Bo, ZHANG Shulin   +4 more
doaj   +1 more source

Uremic toxins promote renal fatty acid synthesis and fibrosis via activating aryl hydrocarbon receptor

Nature Communications
Chronic kidney disease (CKD) affect about 10% of adults worldwide, with dyslipidemia being a common feature. Abnormalities in renal lipid metabolism have been strongly implicated in CKD progression; however, the mechanisms by which CKD leads to lipid ...
Hongyan Xie, Yitao Zhang, Li Lu, Hengjiang Guo, Xi’ang Sun, Ming Ning, Xin Xie, Luxin Li, Yangyang Niu, Jingyao Li, Xin Wang, Lehao Wu, Li Zhou, Wei Zhang, Yingying Zhang, Chen Xu, Limin Lu, Chen Yu   +17 more
doaj   +1 more source

Distinct damage levels and transcriptional responses of lung in Hezuo pigs and Bama pigs during cold exposure [PDF]

Animal Bioscience
Objective The aim of the present study is to compare cold adaptation mechanisms between cold-tolerant Hezuo and cold-sensitive Bama pigs. Methods A total of 40 healthy pigs (75 days old), including 20 Hezuo pigs and 20 Bama pigs, were used in this study.
Yajuan Li, Xiaoli Gao, Yating Zhang, Shuangbao Gun   +3 more
doaj   +1 more source

NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-κB pathway after intracerebral hemorrhage in mice

Journal of Neuroinflammation, 2019
Background Neuroinflammation and blood-brain barrier (BBB) disruption are two vital mechanisms of secondary brain injury following intracerebral hemorrhage (ICH).
Xuan Wu, Siming Fu, Yun Liu, Hansheng Luo, Feng Li, Yiying Wang, Meng Gao, Yuan Cheng, Zongyi Xie   +8 more
doaj   +1 more source