Results 21 to 30 of about 36,777 (126)

Exercise alters the circadian rhythm of REV-ERB-α and downregulates autophagy-related genes in peripheral and central tissues

Scientific Reports, 2022
The transcriptional repressor REV-ERB-α, encoded by Nuclear Receptor Subfamily 1 Group D Member 1 (Nr1d1), has been considered to play an essential role in the skeletal muscle oxidative capacity adaptation and muscle mass control.
Alisson L. da Rocha, Ana P. Pinto, Bruno L. S. Bedo, Gustavo P. Morais, Luciana C. Oliveira, Ruither O. G. Carolino, Jose R. Pauli, Fernando M. Simabuco, Leandro P. de Moura, Eduardo R. Ropelle, Dennys E. Cintra, Donato A. Rivas, Adelino S. R. da Silva   +12 more
doaj   +1 more source

Cartilage-specific knockout of miRNA-128a expression normalizes the expression of circadian clock genes (CCGs) and mitigates the severity of osteoarthritis

Biomedical Journal
Background: Micro-ribonucleic acids (miRNAs) are involved in osteoarthritis (OA) pathogenesis and clock-controlled genes (CCGs) regulation. However, the interaction between miRNAs and CCGs remains unclear.
Jih-Yang Ko, Feng-Sheng Wang, Wei-Shiung Lian, Hsiao-Chi Fang, Shu-Jui Kuo   +4 more
doaj   +1 more source

The miR-182-5p/FGF21/acetylcholine axis mediates the crosstalk between adipocytes and macrophages to promote beige fat thermogenesis

JCI Insight, 2021
A dynamically regulated microenvironment, which is mediated by crosstalk between adipocytes and neighboring cells, is critical for adipose tissue homeostasis and function.
Wen Meng, Ting Xiao, Xiuci Liang, Jie Wen, Xinyi Peng, Jing Wang, Yi Zou, Jiahao Liu, Christie Bialowas, Hairong Luo, Yacheng Zhang, Bilian Liu, Jingjing Zhang, Fang Hu, Meilian Liu, Lily Q. Dong, Zhiguang Zhou, Feng Liu, Juli Bai   +18 more
doaj   +1 more source

Alleviation of Limosilactobacillus reuteri in polycystic ovary syndrome protects against circadian dysrhythmia-induced dyslipidemia via capric acid and GALR1 signaling

npj Biofilms and Microbiomes, 2023
Knowledge gaps that limit the development of therapies for polycystic ovary syndrome (PCOS) concern various environmental factors that impact clinical characteristics. Circadian dysrhythmia contributes to glycometabolic and reproductive hallmarks of PCOS.
Shang Li, Junyu Zhai, Weiwei Chu, Xueying Geng, Dongshuang Wang, Luwei Jiao, Gang Lu, Wai-Yee Chan, Kang Sun, Yun Sun, Zi-Jiang Chen, Yanzhi Du   +11 more
doaj   +1 more source

Circadian dysregulation disrupts gut microbe-related bile acid metabolism

Food & Nutrition Research, 2022
Background: Disturbance of circadian rhythm leads to abnormalities in bile acid (BA) and lipid metabolism, and it is of great significance to explore the relationship between them. This study explored the effects of circadian dysregulation on the rhythms
Rulong Chen, Mengcheng Ruan, Si Chen, Yu Tian, Hualin Wang, Na Li, Junlin Zhang, Xiaoli Yu, Zhiguo Liu   +8 more
doaj   +1 more source

Fasting hijacks proximal tubule circadian control mechanisms to regulate glucose reabsorption via the Nrf1/Sglt2 pathway in mice

Nature Communications
The kidneys contribute to glucose homeostasis by gluconeogenesis and glucose reabsorption. Herein, we identified previously unknown fasting-induced, glucagon-mediated inhibitory effect of the circadian clock gene basic helix-loop-helix ARNT like 1 (Bmal1)
Xiaoyue Pan, Cyrus Mowdawalla, Samantha Bagnato, Jeffrey Pessin, Volker Vallon, M. Mahmood Hussain   +5 more
doaj   +1 more source

The circadian rhythm of bladder clock genes in the spontaneously hypersensitive rat.

PLoS ONE, 2019
Circadian expression rhythms of clock gene products in the bladder are reportedly hindered by clock gene abnormalities. However, the role of clock gene products in various pathological lower urinary tract conditions is unknown. The present study examined
Yusuke Kimura, Masashi Honda, Ryo Sasaki, Tetsuya Yumioka, Hideto Iwamoto, Panagiota Tsounapi, Shuichi Morizane, Katsuya Hikita, Mitsuhiko Osaki, Futoshi Okada, Atsushi Takenaka   +10 more
doaj   +1 more source

LINC01224 facilitates the proliferation and inhibits the radiosensitivity of melanoma cells through the miR‐193a‐5p/NR1D2 axis

Kaohsiung Journal of Medical Sciences, 2022
Melanoma is a skin cancer characterized by early metastasis and high mortality. Radiotherapy is a common treatment for melanoma in patients. Long noncoding RNAs play pivotal roles in regulating the radiosensitivity of many tumors, including melanomas. In
Yu Cui, Yi Zheng, Yue Lu, Muyuan Zhang, Lei Yang, Wei Li   +5 more
doaj   +1 more source

High expression of NR1D1 is associated with good prognosis in triple-negative breast cancer patients treated with chemotherapy

Breast Cancer Research, 2019
Background Nuclear receptor subfamily 1, group D, member 1 (NR1D1) is a ligand-regulated nuclear receptor and transcriptional factor. Although recent studies have implicated NR1D1 as a regulator of DNA repair and proliferation in breast cancers, its ...
Hyelin Na, Jinil Han, Na-Lee Ka, Min-Ho Lee, Yoon-La Choi, Young Kee Shin, Mi-Ock Lee   +6 more
doaj   +1 more source

Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor AResearch in context

EBioMedicine, 2019
Background: The identification of new biomarkers and the development of novel, targetable contexts of vulnerability are of urgent clinical need in drug-resistant metastatic colorectal cancer (mCRC).
Elke Burgermeister, Francesca Battaglin, Fagr Eladly, Wen Wu, Frank Herweck, Nadine Schulte, Johannes Betge, Nicolai Härtel, Jakob N. Kather, Cleo-Aron Weis, Timo Gaiser, Alexander Marx, Christel Weiss, Ralf Hofheinz, Ian S. Miller, Fotios Loupakis, Heinz-Josef Lenz, Annette T. Byrne, Matthias P. Ebert   +18 more
doaj   +1 more source