Results 41 to 50 of about 36,777 (126)

Circadian disruption by simulated shift work aggravates periodontitis via orchestrating BMAL1 and GSDMD-mediated pyroptosis

International Journal of Oral Science
Approximately 20% to 30% of the global workforce is engaged in shift work. As a significant cause of circadian disruption, shift work is closely associated with an increased risk for periodontitis.
Yazheng Wang, Rui Li, Qingyuan Ye, Dongdong Fei, Xige Zhang, Junling Huang, Tingjie Liu, Jinjin Wang, Qintao Wang   +8 more
doaj   +1 more source

Medial prefrontal cortex: genes linked to bipolar disorder and schizophrenia have altered expression in the highly social maternal phenotype

Frontiers in Behavioral Neuroscience, 2014
The transition to motherhood involves CNS changes that modify sociability and affective state. However, these changes also put females at risk for postpartum depression and psychosis, which impairs parenting abilities and adversely affects children ...
Brian E Eisinger, Terri M Driessen, Changjiu eZhao, Stephen eGammie, Stephen eGammie   +4 more
doaj   +1 more source

Targeting RBM10‐Repressed RORB Activity in Liquid Condensates Inhibits Lysosomal Biogenesis and Neuroblastoma Progression via Affecting NF‐κB Signaling

Advanced Science
Neuroblastoma (NB), a pediatric solid malignancy, is distinguished by hetergenous clinical characteristics, including tumor aggressiveness or spontaneous regression.
Yanhua Guo, Xiaojing Wang, Chunhui Yang, Zhijie Wang, Xiaolin Wang, Xinyue Li, Jiaying Qu, Shunchen Zhou, Liduan Zheng, Qiangsong Tong   +9 more
doaj   +1 more source

Targeting Nr2e3 to Modulate Tet2 Expression: Therapeutic Potential for Depression Treatment

Advanced Science
Epigenetic mechanisms such as DNA methylation and hydroxymethylation play a significant role in depression. This research has shown that Ten‐eleven translocation 2 (Tet2) deficiency prompts depression‐like behaviors, but Tet2's transcriptional regulation
Xiaohua Ma, Shiyao Xu, Yaohui Zhou, Qian Zhang, Hao Yang, Bo Wan, Yong Yang, Zhigang Miao, Xingshun Xu   +8 more
doaj   +1 more source

Suberoylanilide Hydroxamic Acid Attenuates Autoimmune Arthritis by Suppressing Th17 Cells through NR1D1 Inhibition

Mediators of Inflammation, 2019
Rheumatoid arthritis (RA) is a type of systemic autoimmune arthritis that causes joint inflammation and destruction. One of the pathological mechanisms of RA is known to involve histone acetylation.
Da Som Kim, Hong-Ki Min, Eun Kyung Kim, Seung Cheon Yang, Hyun Sik Na, Seon-Yeong Lee, Jeong-Won Choi, Kyung-Ah Jung, Seung-Ki Kwok, Sung-Hwan Park, Mi-La Cho   +10 more
doaj   +1 more source

Light pollution during pregnancy influences the growth of offspring in rats

Ecotoxicology and Environmental Safety
Objective: To investigate the effects of excessive light exposure during gestation on intrauterine development and early growth of neonates in rats. Methods: Pregnant rats were randomly allocated to three groups: the constant light exposure group, non ...
Baojing Zhao, Zhen Yu, Junjie Sun, Weisheng Cheng, Tao Yu, Yuanyuan Yang, Zhaolian Wei, Zongzhi Yin   +7 more
doaj   +1 more source

Nr1d1 inhibition mitigates intermittent hypoxia-induced pulmonary hypertension via Dusp1-mediated Erk1/2 deactivation and mitochondrial fission attenuation

Cell Death Discovery
Intermittent hypoxia (IH) precipitates pulmonary vasoconstriction, culminating in the onset of pulmonary hypertension (PH) among individuals afflicted with sleep apnea.
Zhou Pan, Yan Yao, Xu Liu, Yixuan Wang, Xinyue Zhang, Shiqian Zha, Ke Hu   +6 more
doaj   +1 more source

Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock.

PLoS ONE, 2019
Genome-wide association study (GWAS) loci for several immunity-mediated diseases (early onset asthma, inflammatory bowel disease (IBD), primary biliary cholangitis, and rheumatoid arthritis) map to chromosomal region 17q12-q21.
Matthew L Chang, Sanny Moussette, Enrique Gamero-Estevez, José Héctor Gálvez, Victoria Chiwara, Indra R Gupta, Aimee K Ryan, Anna K Naumova   +7 more
doaj   +1 more source

Lappaconitine hydrobromide prevents NLRP3-GSDMD-mediated pyroptosis to alleviate sepsis-induced acute lung injury by enhancing NR1H3

Journal of Pharmaceutical Analysis
Evidence indicates that nuclear receptor subfamily 1 group H member 3 (NR1H3) activation mitigates sepsis-induced acute lung injury (SALI) by reducing inflammatory response.
Yuejia Lan, Qingrui Zhong, Hongkai Huang, Xiao Deng, Lu Yang, Jiayi Sun, Mingyang Liu, Xianli Meng, Jiasi Wu   +8 more
doaj   +1 more source

Nuclear Receptor Subfamily 1 Group D Member 1 [PDF]

, 2020
openaire   +1 more source