Results 11 to 20 of about 36,864 (217)

Circadian clock proteins in mood regulation

Frontiers in Psychiatry, 2015
Mood regulation is known to be affected by the change of seasons. Recent research findings have suggested that mood regulation may be influenced by the function of circadian clocks.
Timo ePartonen
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Polycyclic aromatic hydrocarbons (PAHs) in ambient air of Guangzhou city: Exposure levels, health effects and cytotoxicity

Ecotoxicology and Environmental Safety, 2023
Polycyclic aromatic hydrocarbons (PAHs) in PM2.5 pose potentially serious threats to human health. In this study, the distribution characteristics of 16 priority controlled, fine PM (PM2.5)-bound PAHs in the ambient air of Guangzhou city were analysed ...
Guanqing Jiang, Xu Song, Jiaying Xie, Tongxing Shi, Qiaoyuan Yang   +4 more
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Daily rhythmicity of clock gene transcripts in atlantic cod fast skeletal muscle. [PDF]

PLoS ONE, 2014
The classical notion of a centralized clock that governs circadian rhythmicity has been challenged with the discovery of peripheral oscillators that enable organisms to cope with daily changes in their environment. The present study aimed to identify the
Carlo C Lazado, Hiruni P S Kumaratunga, Kazue Nagasawa, Igor Babiak, Alessia Giannetto, Jorge M O Fernandes   +5 more
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NR1D1 suppressed the growth of ovarian cancer by abrogating the JAK/STAT3 signaling pathway

BMC Cancer, 2021
Background Nuclear receptor subfamily 1 group D member 1 (NR1D1), a nuclear receptor associated with a variety of physiological processes, has a low level in ovarian cancer tissues compared with adjacent normal tissues.
Huailin Wang, Yan Fu
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m6A methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis

Pharmacological Research, 2023
The roles of nuclear receptor subfamily 1 group d member 1 (NR1D1) and the circadian clock in liver fibrosis remain unclear. Here, we showed that liver clock genes, especially NR1D1, were dysregulated in mice with carbon tetrachloride (CCl4)-induced ...
Li Chen, Siwei Xia, Feixia Wang, Yuanyuan Zhou, Shuqi Wang, Ting Yang, Yang Li, Min Xu, Ya Zhou, Desong Kong, Zili Zhang, Jiangjuan Shao, Xuefen Xu, Feng Zhang, Shizhong Zheng   +14 more
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Gut microbiota-derived metabolites contribute negatively to hindgut barrier function development at the early weaning goat model

Animal Nutrition, 2022
Early weaning induces intestinal injury, leading to a series of long-term symptoms such as inflammation, malabsorption and diarrhea. In this study, we hypothesized that microbes and their metabolites modulate the host's inflammatory response to early ...
Ke Zhang, Yangbin Xu, Yuxin Yang, Mengmeng Guo, Ting Zhang, Bo Zong, Shuhong Huang, Langda Suo, Baohua Ma, Xiaolong Wang, Yujiang Wu, Daniel Brugger, Yulin Chen   +12 more
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NR1D1 controls skeletal muscle calcium homeostasis through myoregulin repression

JCI Insight, 2022
The sarcoplasmic reticulum (SR) plays an important role in calcium homeostasis. SR calcium mishandling is described in pathological conditions, such as myopathies. Here, we investigated whether the nuclear receptor subfamily 1 group D member (NR1D1, also
Alexis Boulinguiez, Christian Duhem, Alicia Mayeuf-Louchart, Benoit Pourcet, Yasmine Sebti, Kateryna Kondratska, Valérie Montel, Stéphane Delhaye, Quentin Thorel, Justine Beauchamp, Aurore Hebras, Marion Gimenez, Marie Couvelaere, Mathilde Zecchin, Lise Ferri, Natalia Prevarskaya, Anne Forand, Christel Gentil, Jessica Ohana, France Piétri-Rouxel, Bruno Bastide, Bart Staels, Helene Duez, Steve Lancel   +23 more
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Exercise alters the circadian rhythm of REV-ERB-α and downregulates autophagy-related genes in peripheral and central tissues

Scientific Reports, 2022
The transcriptional repressor REV-ERB-α, encoded by Nuclear Receptor Subfamily 1 Group D Member 1 (Nr1d1), has been considered to play an essential role in the skeletal muscle oxidative capacity adaptation and muscle mass control.
Alisson L. da Rocha, Ana P. Pinto, Bruno L. S. Bedo, Gustavo P. Morais, Luciana C. Oliveira, Ruither O. G. Carolino, Jose R. Pauli, Fernando M. Simabuco, Leandro P. de Moura, Eduardo R. Ropelle, Dennys E. Cintra, Donato A. Rivas, Adelino S. R. da Silva   +12 more
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Cartilage-specific knockout of miRNA-128a expression normalizes the expression of circadian clock genes (CCGs) and mitigates the severity of osteoarthritis

Biomedical Journal
Background: Micro-ribonucleic acids (miRNAs) are involved in osteoarthritis (OA) pathogenesis and clock-controlled genes (CCGs) regulation. However, the interaction between miRNAs and CCGs remains unclear.
Jih-Yang Ko, Feng-Sheng Wang, Wei-Shiung Lian, Hsiao-Chi Fang, Shu-Jui Kuo   +4 more
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The miR-182-5p/FGF21/acetylcholine axis mediates the crosstalk between adipocytes and macrophages to promote beige fat thermogenesis

JCI Insight, 2021
A dynamically regulated microenvironment, which is mediated by crosstalk between adipocytes and neighboring cells, is critical for adipose tissue homeostasis and function.
Wen Meng, Ting Xiao, Xiuci Liang, Jie Wen, Xinyi Peng, Jing Wang, Yi Zou, Jiahao Liu, Christie Bialowas, Hairong Luo, Yacheng Zhang, Bilian Liu, Jingjing Zhang, Fang Hu, Meilian Liu, Lily Q. Dong, Zhiguang Zhou, Feng Liu, Juli Bai   +18 more
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