Results 11 to 20 of about 5,296 (150)

The role of REV-ERB in NASH [PDF]

Acta Pharmacologica Sinica, 2022
REV-ERBs are atypical nuclear receptors as they function as ligand-regulated transcriptional repressors. The natural ligand for the REV-ERBs (REV-ERBα and REV-ERBβ) is heme, and heme-binding results in recruitment of transcriptional corepressor proteins such as N-CoR that mediates repression of REV-ERB target genes. These two receptors regulate a large
Kristine Griffett, Thomas Burris, Burris Thomas P   +2 more
exaly   +4 more sources

Rev-erb regulation of cholesterologenesis [PDF]

Biochemical Pharmacology, 2017
REV-ERBα and REV-ERBβ are heme regulated nuclear receptors that are known to regulate metabolic pathways. We previously demonstrated that treatment of mice with synthetic REV-ERB agonists suppressed plasma cholesterol levels and the hepatic levels of the rate limiting enzyme in cholesterol biosynthesis (3-hydroxy-3-methylglutaryl-CoA reductase).
Jinsong Zhang, Thomas Burris, Sadichha Sitaula   +2 more
exaly   +4 more sources

Suppression of atherosclerosis by synthetic REV-ERB agonist [PDF]

Biochemical and Biophysical Research Communications, 2015
The nuclear receptors for heme, REV-ERBα and REV-ERBβ, play important roles in the regulation of metabolism and inflammation. Recently it was demonstrated that reduced REV-ERBα expression in hematopoetic cells in LDL receptor null mice led to increased atherosclerosis.
Laura Solt, Theodore Kamenecka, Thomas Burris   +2 more
exaly   +5 more sources

Direct regulation of CLOCK expression by REV-ERB. [PDF]

PLoS ONE, 2011
Circadian rhythms are regulated at the cellular level by transcriptional feedback loops leading to oscillations in expression of key proteins including CLOCK, BMAL1, PERIOD (PER), and CRYPTOCHROME (CRY).
Christine Crumbley, Thomas P Burris
doaj   +4 more sources

Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation. [PDF]

PLoS ONE, 2016
The circadian clock maintains appropriate timing for a wide range of behaviors and physiological processes. Circadian behaviors such as sleep and wakefulness are intrinsically dependent on the precise oscillation of the endogenous molecular machinery ...
Ariadna Amador, Salvador Huitron-Resendiz, Amanda J Roberts, Theodore M Kamenecka, Laura A Solt, Thomas P Burris   +5 more
doaj   +4 more sources

Muscle Rev-erb controls time-dependent adaptations to chronic exercise in mice [PDF]

Nature Communications
The best time of the day for chronic exercise training and the mechanism underlying the timing effects is unclear. Here, we show that low-intensity, low-volume treadmill training in mice before sleep yields greater benefits than after waking for muscle ...
Jidong Liu, Fang Xiao, Abhinav Choubey, Udhaya Kumar S, Yanxiang Wang, Sungguan Hong, Tingting Yang, Husniye Gul Otlu, Ege Sanem Oturmaz, Emanuele Loro, Yuxiang Sun, Pradip Saha, Tejvir S. Khurana, Li Chen, Xinguo Hou, Zheng Sun   +15 more
doaj   +2 more sources

Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease. [PDF]

PLoS ONE, 2019
Alzheimer's disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease.
Deborah A Roby, Fernanda Ruiz, Bailey A Kermath, Jaymie R Voorhees, Michael Niehoff, Jinsong Zhang, John E Morley, Erik S Musiek, Susan A Farr, Thomas P Burris   +9 more
doaj   +2 more sources

Rev-erbs and Glia—Implications for Neurodegenerative Diseases [PDF]

Journal of Experimental Neuroscience, 2019
Recently, we described a role for the circadian clock protein and nuclear receptor Rev-erbα in regulating glial activation states in the brain. Deletion of Rev-erbα resulted in microglial as well as astrocytic activation, while a Rev-erbα agonist ...
Percy Griffin, Julie M Dimitry, Erik S Musiek   +2 more
doaj   +4 more sources

Hindbrain REV-ERB nuclear receptors regulate sensitivity to diet-induced obesity and brown adipose tissue pathophysiology [PDF]

Molecular Metabolism
Objective: The dorsal vagal complex (DVC) of the hindbrain is a major point of integration for central and peripheral signals that regulate a wide variety of metabolic functions to maintain energy balance.
Lauren N. Woodie, Lily C. Melink, Ahren J. Alberto, Michelle Burrows, Samantha M. Fortin, Calvin C. Chan, Matthew R. Hayes, Mitchell A. Lazar   +7 more
doaj   +2 more sources

REV-ERBα Regulates TH17 Cell Development and Autoimmunity

Cell Reports, 2018
Summary: RORγt is well recognized as the lineage-defining transcription factor for T helper 17 (TH17) cell development. However, the cell-intrinsic mechanisms that negatively regulate TH17 cell development and autoimmunity remain poorly understood. Here,
Douglas Kojetin, Jinsai Shang, Laura Solt   +2 more
exaly   +3 more sources