Results 41 to 50 of about 5,296 (150)

Rev-erb Agonist Inhibits Chikungunya and O'nyong'nyong Virus Replication. [PDF]

Open Forum Infect Dis, 2018
Abstract Chikungunya virus (CHIKV), an alphavirus spread by Aedes spp. mosquitos, causes severe inflammation and joint pain, progressing to a chronic arthralgic state in a subset of patients. Due to recent global epidemics of CHIKV and the potential for related viruses to cause outbreaks, multiple approaches to combat these pathogens are
Hwang J, Jiang A, Fikrig E.
europepmc   +4 more sources

Regulation of Adipogenesis by Natural and Synthetic REV-ERB Ligands [PDF]

Endocrinology, 2010
The nuclear hormone receptor, REV-ERB, plays an essential role in adipogenesis. Rev-erbα expression is induced in 3T3-L1 cells during adipogenesis, and overexpression of this receptor leads to expression of adipogenic genes. We recently demonstrated that the porphyrin heme functions as a ligand for REV-ERB, and binding of heme is required for the ...
Naresh, Kumar, Laura A, Solt, Yongjun, Wang, Pamela M, Rogers, Gargi, Bhattacharyya, Theodore M, Kamenecka, Keith R, Stayrook, Christine, Crumbley, Z Elizabeth, Floyd, Jeffrey M, Gimble, Patrick R, Griffin, Thomas P, Burris   +11 more
openaire   +2 more sources

Circadian Clock Genes REV-ERBs Inhibits Granulosa Cells Apoptosis by Regulating Mitochondrial Biogenesis and Autophagy in Polycystic Ovary Syndrome

Frontiers in Cell and Developmental Biology, 2021
Polycystic ovary syndrome (PCOS) is an endocrinopathy with complex pathophysiology that is a common cause of anovulatory infertility in women. Although the disruption of circadian rhythms is indicated in PCOS, the role of the clock in the etiology of ...
Lihua Sun, Hui Tian, Songguo Xue, Hongjuan Ye, Xue Xue, Rongxiang Wang, Yu Liu, Caixia Zhang, Qiuju Chen, Shaorong Gao   +9 more
doaj   +1 more source

REV-ERB and ROR nuclear receptors as drug targets [PDF]

Nature Reviews Drug Discovery, 2014
The nuclear receptors REV-ERB (consisting of REV-ERBα and REV-ERBβ) and retinoic acid receptor-related orphan receptors (RORs; consisting of RORα, RORβ and RORγ) are involved in many physiological processes, including regulation of metabolism, development and immunity as well as the circadian rhythm.
Douglas J, Kojetin, Thomas P, Burris
openaire   +2 more sources

Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages

eLife, 2016
Although macrophages can be polarized to distinct phenotypes in vitro with individual ligands, in vivo they encounter multiple signals that control their varied functions in homeostasis, immunity, and disease.
Dawn Z Eichenfield, Ty Dale Troutman, Verena M Link, Michael T Lam, Han Cho, David Gosselin, Nathanael J Spann, Hanna P Lesch, Jenhan Tao, Jun Muto, Richard L Gallo, Ronald M Evans, Christopher K Glass   +12 more
doaj   +1 more source

Expression of AFP and Rev-Erb A/Rev-Erb B and N-CoR in fetal rat liver, liver injury and liver regeneration [PDF]

Comparative Hepatology, 2006
AbstractBackgroundAlpha-fetoprotein (AFP) expression can resume in the adult liver under pathophysiological conditions. Orphan nuclear receptors were supposed to regulate AFP gene expression,in vitro. We were interested to study the expression of AFP and orphan nuclear receptors,in vivo.ResultsThe expression of AFP gene and orphan nuclear receptors in ...
Meier, Volker, Tron, Kyrylo, Batusic, Danko, Elmaouhoub, Abderrahim, Ramadori, Giuliano   +4 more
openaire   +3 more sources

Social isolation increases metabolic rate in the transition of light- to dark- phase and advances Rev-erb-α expression in brown adipose tissue to regulate daily rhythm of core body temperature in mice

Journal of Photochemistry and Photobiology, 2023
Mammals use social thermoregulation to maintain the core body temperature (Tc) at a lower energy cost. Brown adipose tissue (BAT) plays a crucial role in thermoregulation.
Paola Fernandes, Hellen Nunes, Tamires Amorim Marinho, Pietra Souza Barsanele, Maria Nathália Moraes, Maristela de Oliveira Poletini   +5 more
doaj   +1 more source

SR9009 inhibits lethal prostate cancer subtype 1 by regulating the LXRα/FOXM1 pathway independently of REV-ERBs

Cell Death and Disease, 2022
Perturbations of the circadian clock are linked to multiple diseases, including cancers. Pharmacological activation of REV-ERB nuclear receptors, the core components of the circadian clock, has antitumor effects on various malignancies, while the impact ...
Hang Xu, Jiapeng Zhang, Xiaonan Zheng, Ping Tan, Xingyu Xiong, Xianyanling Yi, Yang Yang, Yan Wang, Dazhou Liao, Hong Li, Qiang Wei, Jianzhong Ai, Lu Yang   +12 more
doaj   +1 more source

In Vitro Metabolic Studies of REV-ERB Agonists SR9009 and SR9011. [PDF]

Int J Mol Sci, 2016
SR9009 and SR9011 are attractive as performance-enhancing substances due to their REV-ERB agonist effects and thus circadian rhythm modulation activity. Although no pharmaceutical preparations are available yet, illicit use of SR9009 and SR9011 for doping purposes can be anticipated, especially since SR9009 is marketed in illicit products.
Geldof L, Deventer K, Roels K, Tudela E, Van Eeno P.   +4 more
europepmc   +5 more sources

A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity. [PDF]

Proceedings of the National Academy of Sciences, 1996
Rev-erb alpha belongs to the nuclear receptor superfamily, which contains receptors for steroids, thyroid hormones, retinoic acid, and vitamin D, as well as "orphan" receptors. No ligand has been found for Rev-erb alpha to date, making it one of these orphan receptors.
G, Adelmant, A, Bègue, D, Stéhelin, V, Laudet   +3 more
openaire   +2 more sources