REV-ERBβ is required to maintain normal wakefulness and the wake-inducing effect of dual REV-ERB agonist SR9009 [PDF]
Biochemical Pharmacology, 2018 Laura Solt +2 more
exaly +2 more sources
REV-ERB ALPHA polymorphism is associated with obesity in the Spanish obese male population. [PDF]
PLoS ONE, 2014 REV-ERB ALPHA has been shown to link metabolism with circadian rhythms. We aimed to identify new polymorphisms in the promoter of REV-ERB ALPHA and tested whether these polymorphisms could be associated with obesity in the Spanish population. Of the 1197
Elena G Ruano +2 more
doaj +1 more source
Circadian control of hepatitis B virus replication
Nature Communications, 2021 The circadian factors BMAL1/CLOCK and REV-ERB are master regulators of the human liver transcriptome but their role in hepatitis B virus infection is largely unknown. Here, Zhuang et al.
Xiaodong Zhuang +21 more
doaj +1 more source
Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression. [PDF]
PLoS ONE, 2016 The nuclear receptors REV-ERBα and REV-ERBβ are transcription factors that play pivotal roles in the regulation of the circadian rhythm and various metabolic processes.
Ariadna Amador +5 more
doaj +1 more source
Rev-erb agonist SR9009 inhibits the proliferation of human colon cancer cell line HCT116 through reducing autophagy [PDF]
Jichu yixue yu linchuang, 2020 Objective To investigate the effect of hemeregulated nuclear receptor(Rev-erb) agonist SR9009 on the proliferation and potential mechanism of human colon cancer cell line HCT116.
SHI Guang, NING Na, HOU Xiao-hong, SUN Cong, YUAN Yuan, WANG Li, WANG Xiao-hui
doaj
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β [PDF]
Nature, 2012 The circadian clock acts at the genomic level to coordinate internal behavioural and physiological rhythms via the CLOCK-BMAL1 transcriptional heterodimer. Although the nuclear receptors REV-ERB-α and REV-ERB-β have been proposed to form an accessory feedback loop that contributes to clock function, their precise roles and importance remain unresolved.
Cho, Han +14 more
openaire +3 more sources
Rev-erb agonist improves adverse cardiac remodeling and survival in myocardial infarction through an anti-inflammatory mechanism. [PDF]
PLoS ONE, 2017 Rev-erb α, known as nuclear receptor 1D1 (NR1D1), regulates circadian rhythm, modulates glucose and lipid metabolism, and inflammatory response. However, little is known about the effect of Rev-erb agonist on the progression of myocardial infarction (MI)
Endin Nokik Stujanna +12 more
doaj +1 more source
Neurobiology of Sleep and Circadian Rhythms, 2023 Mild traumatic brain injury (mTBI) or concussion is a common injury worldwide leading to substantial medical costs and a high burden on society. In adolescents, falls and sports related trauma are often the causes of mTBI.
Marissa Sgro +6 more
doaj +1 more source
REV-ERBs: More Than the Sum of the Individual Parts [PDF]
Cell Metabolism, 2012 REV-ERB nuclear receptors have been believed to stabilize the circadian clock machinery through an accessory but dispensable feedback loop. Recent work now challenges this assumption by demonstrating that REV-ERBs are essential core clock components, in addition to serving as pivotal regulators of rhythmic metabolism.
Stratmann Markus, Schibler Ueli
openaire +3 more sources
Adipocyte NR1D1 dictates adipose tissue expansion during obesity
eLife, 2021 The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global Nr1d1 deletion driving dysregulation of white adipose tissue (WAT) lipogenesis and obesity.
Ann Louise Hunter +15 more
doaj +1 more source